The role of learning on industrial simulation design and analysis

The capability of modeling real-world system operations has turned simulation into an indispensable problemsolving methodology for business system design and analysis. Today, simulation supports decisions ranging from sourcing to operations to finance, starting at the strategic level and proceeding towards tactical and operational levels of decision-making. In such a dynamic setting, the practice of simulation goes beyond being a static problem-solving exercise and requires integration with learning. This article discusses the role of learning in simulation design and analysis motivated by the needs of industrial problems and describes how selected tools of statistical learning can be utilized for this purpose

Evaluating critical bits in arithmetic operations due to timing violations

Various error models are being used in simulation of voltage-scaled arithmetic units to examine application-level tolerance of timing violations. The selection of an error model needs further consideration, as differences in error models drastically affect the performance of the application. Specifically, floating point arithmetic units (FPUs) have architectural characteristics that characterize its behavior. We examine the architecture of FPUs and design a new error model, which we call Critical Bit. We run selected benchmark applications with Critical Bit and other widely used error injection models to demonstrate the differences

Energy-efficient and high-performance lock speculation hardware for embedded multicore systems

Embedded systems are becoming increasingly common in everyday life and like their general-purpose counterparts, they have shifted towards shared memory multicore architectures. However, they are much more resource constrained, and as they often run on batteries, energy efficiency becomes critically important. In such systems, achieving high concurrency is a key demand for delivering satisfactory performance at low energy cost. In order to achieve this high concurrency, consistency across the shared memory hierarchy must be accomplished in a cost-effective manner in terms of performance, energy, and implementation complexity. In this article, we propose Embedded-Spec, a hardware solution for supporting transparent lock speculation, without the requirement for special supporting instructions. Using this approach, we evaluate the energy consumption and performance of a suite of benchmarks, exploring a range of contention management and retry policies. We conclude that for resource-constrained platforms, lock speculation can provide real benefits in terms of improved concurrency and energy efficiency, as long as the underlying hardware support is carefully configured.This work is supported in part by NSF under Grants CCF-0903384, CCF-0903295, CNS-1319495, and CNS-1319095 as well the Semiconductor Research Corporation under grant number 1983.001. (CCF-0903384 - NSF; CCF-0903295 - NSF; CNS-1319495 - NSF; CNS-1319095 - NSF; 1983.001 - Semiconductor Research Corporation

Three-dimensional fluorescent microscopy via simultaneous illumination and detection at multiple planes.

The conventional optical microscope is an inherently two-dimensional (2D) imaging tool. The objective lens, eyepiece and image sensor are all designed to capture light emitted from a 2D 'object plane'. Existing technologies, such as confocal or light sheet fluorescence microscopy have to utilize mechanical scanning, a time-multiplexing process, to capture a 3D image. In this paper, we present a 3D optical microscopy method based upon simultaneously illuminating and detecting multiple focal planes. This is implemented by adding two diffractive optical elements to modify the illumination and detection optics. We demonstrate that the image quality of this technique is comparable to conventional light sheet fluorescent microscopy with the advantage of the simultaneous imaging of multiple axial planes and reduced number of scans required to image the whole sample volume

COMPARISON OF POST OPERATIVE EPIDURAL ANALGESIA EFFECT USING CONTINUOUS 0.125% BUPIVACAINE WITH BOLUS 3 MG MORPHINE ON INSULIN LEVELS IN PATIENT UNDERGOING LOWER LIMB SURGERY

The procedure for lower limb surgery is one of the major and long-standing operations. Surgical trauma stimulates the stress response of surgery. The surgical stress response will interfere with stress hormones including insulin. Insulin is an anabolic hormone that is important in the body and has a role in the process of wound healing. Previous studies have shown insulin levels to correlate with increased surgical stress and the type of anesthesia given. This study analyzed differences insulin levels in bupivacaine 0,125% with morphine 3 mg and to compare the analgesia effect of continuous bupivacaine 0,125% with 3 mg morphine epidural in postoperative lower extremity assessed from insulin levels. A retrospective cohort study taken from secondary data from previous studies and their medical records at RSUP Dr. Mohammad Hoesin Palembang. Statistical analysis used STATA 15th edition. Wilcoxon showed that there was a significant difference in 0,125% bupivacaine group on insulin leves after 12th hours postoperative (p0.05). In this study, there was no significant difference between the 0,125% bupivacaine with 3 mg morphine on insulin level

Anharmonicity and self-similarity of the free energy landscape of protein G

The near-native free energy landscape of protein G is investigated through 0.4 microseconds-long atomistic molecular dynamics simulations in explicit solvent. A theoretical and computational framework is used to assess the time-dependence of salient thermodynamical features. While the quasi-harmonic character of the free energy is found to degrade in a few ns, the slow modes display a very mild dependence on the trajectory duration. This property originates from a striking self-similarity of the free energy landscape embodied by the consistency of the principal directions of the local minima, where the system dwells for several ns, and of the virtual jumps connecting them.Comment: revtex, 6 pages, 5 figure

Perbedaan Derajat Nyeri Haid Pasien Endometriosis Sebelum dan Sesudah Tindakan Laparoskopi di RSUP Dr. Mohammad Hoesin Palembang

Endometriosis didefinisikan sebagai keberadaan kelenjar dan stroma endometrium di luar kavum uteri. Penelitian ini bertujuan untuk mengetahui perbedaan derajat nyeri haid pasien endometriosis sebelum dan sesudah tindakan laparoskopi. Penelitian yang dilakukan ini bersifat analitik observasional dengan menggunakan pendekatan potong lintang dengan besar sampel yang memenuhi kriteria inklusi sebanyak 44 orang. Data diperoleh dari data primer hasil pengisian kuesioner pasien endometriosis yang melakukan tindakan laparoskopi dan juga data sekunder dari rekam medik RSUP Dr. Mohammad Hoesin Palembang dari bulan Januari 2014 sampai bulan Agustus 2014. Penelitian ini menunjukkan pasien endometriosis banyak terjadi pada usia 15-45 tahun (90,9%) dengan rata-rata usia adalah 33,52, derajat endometriosis ditemukan sama antara derajat I, II, dan IV sebanyak 13 orang (29,5%), dan IMT dengan frekuensi terbesar berkisar 18,5-25,0 (77,5%). Dari hasil analisis didapatkan ada perbedaan sangat bermakna rata-rata VAS nyeri haid sebelum dan sesudah tindakan laparoskopi (p= 0,000), dan ada perbedaan sangat bermakna rata-rata VAS nyeri haid sebelum dan sesudah tindakan laparoskopi berdasarkan derajat endometriosis I, II, III, dan IV (p= 0,001). Ada perbedaan antara derajat nyeri haid pasien endometriosis sebelum dan sesudah tindakan laparoskopi