Modelling the steady state spectral energy distribution of the BL-Lac Object PKS 2155-304 using a selfconsistent SSC model

In this paper we present a fully selfconsistent SSC model with particle acceleration due to shock and stochastic acceleration (Fermi-I and Fermi-II-Processes respectively) to model the quiescent spectral energy distribution (SED) observed from PKS 2155. The simultaneous August/September 2008 multiwavelength data of H.E.S.S., Fermi, RXTE, SWIFT and ATOM give new constraints to the high-energy peak in the SED concerning its curvature. We find that, in our model, a monoenergetic injection of electrons at $\gamma_0 = 910$ into the model region, which are accelerated by Fermi-I- and Fermi-II-processes while suffering synchrotron and inverse Compton losses, finally leads to the observed SED of PKS 2155-30.4 shown in H.E.S.S. and Fermi-LAT collaborations (2009). In contrast to other SSC models our parameters arise from the jet's microphysics and the spectrum is evolving selfconsistently from diffusion and acceleration. The $\gamma_0$-factor can be interpreted as two counterstreaming plasmas due to the motion of the blob at a bulk factor of $\Gamma = 58$ and opposed moving upstream electrons at moderate Lorentz factors with an average of $\gamma_u \approx 8$.Comment: 4 figure

Impact of degeneration and material pairings on cartilage friction: Cartilage versus glass

The association of knee joint osteoarthritis and altered frictional properties of the degenerated cartilage remains ambiguous, because previous in vitro studies did not consider the characteristic loads and velocities during gait. Therefore, the aim of this study was to quantify the friction behavior of degenerated human cartilage under characteristic stance and swing phase conditions. A dynamic pin-on-plate tribometer was used to test the tribological systems of cartilage against cartilage and cartilage against glass, both with synthetic synovial fluid as lubricant. Using the International Cartilage Repair Society classification, the cartilage samples were assigned to a mildly or a severely degenerated group before testing. Friction coefficients were calculated under stance and swing phase conditions at the beginning of the test and after 600 s of testing. The most important finding of this study is that cartilage against glass couplings displayed significantly higher friction for the severely degenerated samples compared to the mildly degenerated ones, whereas cartilage against cartilage couplings only indicated slight tendencies under the observed test conditions. Consequently, care should be taken when transferring in vitro findings from cartilage against cartilage couplings to predict the friction behavior in vivo. Therefore, we recommend in vitro tribological testing methods which account for gait-like loading conditions and to replicate physiological material pairings, particularly in preclinical medical device validation studies

An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations

Caries, the world’s most common chronic disease, remains a major cause of invasive restorative dental treatment. To take advantage of the diagnostic potential of optical coherence tomography (OCT) in contemporary dental prevention and treatment, an intraorally applicable spectral-domain OCT probe has been developed based on an OCT hand-held scanner equipped with a rigid 90°-optics endoscope. The probe was verified in vitro. In vivo, all tooth surfaces could be imaged with the OCT probe, except the vestibular surfaces of third molars and the proximal surface sections of molars within a 'blind spot' at a distance greater than 2.5 mm from the tooth surface. Proximal surfaces of 64 posterior teeth of four volunteers were assessed by intraoral OCT, visual-tactile inspection, bitewing radiography and fiber-optic transillumination. The agreement in detecting healthy and carious surfaces varied greatly between OCT and established methods (18.2–94.7%), whereby the established methods could always be supplemented by OCT. Direct and indirect composite and ceramic restorations with inherent imperfections and failures of the tooth-restoration bond were imaged and qualitatively evaluated. The intraoral OCT probe proved to be a powerful technological approach for the non-invasive imaging of healthy and carious hard tooth tissues and gingiva as well as tooth-colored restorations

Physiological cell bioprinting density in human bone-derived cell-laden scaffolds enhances matrix mineralization rate and stiffness under dynamic loading

Human organotypic bone models are an emerging technology that replicate bone physiology and mechanobiology for comprehensive in vitro experimentation over prolonged periods of time. Recently, we introduced a mineralized bone model based on 3D bioprinted cell-laden alginate-gelatin-graphene oxide hydrogels cultured under dynamic loading using commercially available human mesenchymal stem cells. In the present study, we created cell-laden scaffolds from primary human osteoblasts isolated from surgical waste material and investigated the effects of a previously reported optimal cell printing density (5 × 10$^{6}$ cells/mL bioink) vs. a higher physiological cell density (10 × 10$^{6}$ cells/mL bioink). We studied mineral formation, scaffold stiffness, and cell morphology over a 10-week period to determine culture conditions for primary human bone cells in this microenvironment. For analysis, the human bone-derived cell-laden scaffolds underwent multiscale assessment at specific timepoints. High cell viability was observed in both groups after bioprinting (>90%) and after 2 weeks of daily mechanical loading (>85%). Bioprinting at a higher cell density resulted in faster mineral formation rates, higher mineral densities and remarkably a 10-fold increase in stiffness compared to a modest 2-fold increase in the lower printing density group. In addition, physiological cell bioprinting densities positively impacted cell spreading and formation of dendritic interconnections. We conclude that our methodology of processing patient-specific human bone cells, subsequent biofabrication and dynamic culturing reliably affords mineralized cell-laden scaffolds. In the future, in vitro systems based on patient-derived cells could be applied to study the individual phenotype of bone disorders such as osteogenesis imperfecta and aid clinical decision making

Scattering States of Plektons (PARTICLES with Braid Group Statistics) in 2+1 Dimensional Quantum Field Theory

A Haag-Ruelle scattering theory for particles with braid group statistics is developed, and the arising structure of the Hilbert space of multiparticle states is analyzed.Comment: 18 pages, LATEX, DAMTP-94-9

TRY plant trait database – enhanced coverage and open access

Plant traits - the morphological, anatomical, physiological, biochemical and phenological characteristics of plants - determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits - almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives

Untersuchung eines porösen, keramischen Biomaterials auf Basis von TiO 2 und Perlit am Modell humaner Osteoblasten

In this study, a novel porous ceramic material is introduced and investigated for basic biocompatibility and possible application as bone graft. The material is a sintered compound of the volcanic silicate perlite and rutile TiO2, with a macrostructure of interconnecting accessible pores. It is both inexpensive and easy to manufacture. Since perlite has not been used as a biomaterial before, we first investigated the material for corrosion and leaching of trace elements under extended incubation in saline for 21 days. No significant corrosion was noted. The supernatants did not contain critical concentrations of potentially toxic trace elements. Basic biocompatibility of the material was tested by incubating murine L929 fibroblasts in material-conditioned medium for 24 h. No cytotoxicity was noted. Complement activation was assayed employing a model of anticoagulated human full blood. An uncritical elevation of C5a was observed. In an additional in vitro model, primary human osteoblast-like cells were seeded directly onto samples of the material and its constituent components and incubated for 9 days. The material and samples of its constituent components sustained human osteoblast attachment and proliferation and did not induce a critical expression of inflammatory cytokines. We conclude that Ecopore is highly biocompatible and suitable for bone grafting