Seismic behavior of bifurcated concrete filled steel tube columns with a multi-cavity structure

In order to meet the architecture and construction needs of high rise buildings, the special-shaped columns are becoming more and more widely used. In this study, cyclic tests on seven special-shaped bifurcated Concrete Filled Steel Tube (CFST) columns are carried out. Test variables are the column cross section types and the loading directions. The strength, ductility, hysteretic behavior, energy dissipation ability, failure modes and seismic mechanisms are analyzed. Test results show that: the cross-section type of the column is the main factor influencing the seismic behavior of the specimens. Compared with the basic cross section type, the strength, ductility and energy dissipation capacity of the strengthened cross section type all significantly increased. The cross sections with the inserted angle steel or circular steel tube have the best comprehensive seismic behavior. Also, the loading direction has a considerable influence on the seismic behavior. Compares with the short axis loading specimen C1-Y, the strength of the long axis specimen C1-X and 45° axis C1-Z increase by 92.5 % and 44.0 %, respectively, indicating that the differences in loading direction should be taken into consideration in the seismic design. Based on the test results, the FEM analysis are also carried out. The FEM results show a satisfactory agreement with experimental results. The concrete constitutive relationship and modelling method proposed is suitable for the simulation of special-shaped bifurcated CFST columns with multiple cavities

STUDY ON THE SEISMIC PERFORMANCE OF RECYCLED AGGREGATE CONCRETE-FILLED LIGHTWEIGHT STEEL TUBE FRAME WITH DIFFERENT ASSEMBLY JOINTS

In order to investigate the construction of column-to-beam joints and to understand the effect of recycled aggregate concrete (RAC) and cross-section of beams and columns on the seismic performance of recycled aggregate concrete-filled light steel tubular frame structure, four new types of assembly joints were proposed in this paper. A low cyclic loading test of six frame specimens was carried out. The failure characteristic, load bearing capacity, hysteresis property, ductility, strength and stiffness degradation, and energy dissipation were analysed. The damage process of the specimen was simulated using the ABAQUS software, and the results agreed well with those obtained from the experiments. The results showed that the construction pathway of the joints exhibited significant influence on the seismic performance of the frame. The proposed reinforced joint (using angle steel and stiffeners) significantly improved the bearing capacity, stiffness and energy dissipation capacity of the recycled aggregate concrete-filled steel tube frame. The seismic performance of the steel frame was improved, while the energy dissipation capacity increased by 635.7% using RAC filled in the steel tubes. Finally, by appropriately increasing the size of cross-section on the beams and columns can improve the bearing capacity, stiffness and ductility of the structure

Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia

Abstract Background Elderly patients with relapsed and refractory acute lymphoblastic leukemia (ALL) have poor prognosis. Autologous CD19 chimeric antigen receptor-modified T (CAR-T) cells have potentials to cure patients with B cell ALL; however, safety and efficacy of allogeneic CD19 CAR-T cells are still undetermined. Case presentation We treated a 71-year-old female with relapsed and refractory ALL who received co-infusion of haplo-identical donor-derived CD19-directed CAR-T cells and mobilized peripheral blood stem cells (PBSC) following induction chemotherapy. Undetectable minimal residual disease by flow cytometry was achieved, and full donor cell engraftment was established. The transient release of cytokines and mild fever were detected. Significantly elevated serum lactate dehydrogenase, alanine transaminase, bilirubin and glutamic-oxalacetic transaminase were observed from days 14 to 18, all of which were reversible after immunosuppressive therapy. Conclusions Our preliminary results suggest that co-infusion of haplo-identical donor-derived CAR-T cells and mobilized PBSCs may induce full donor engraftment in relapsed and refractory ALL including elderly patients, but complications related to donor cell infusions should still be cautioned. Trial registration Allogeneic CART-19 for Elderly Relapsed/Refractory CD19+ ALL. NCT0279955

Expert Consensus on Microtransplant for Acute Myeloid Leukemia in Elderly Patients -Report From the International Microtransplant Interest Group

Recent studies have shown that microtransplant (MST) could improve outcome of patients with elderly acute myeloid leukemia (EAML). To further standardize the MST therapy and improve outcomes in EAML patients, based on analysis of the literature on MST, especially MST with EAML from January 1st, 2011 to November 30th, 2022, the International Microtransplant Interest Group provides recommendations and considerations for MST in the treatment of EAML. Four major issues related to MST for treating EAML were addressed: therapeutic principle of MST (1), candidates for MST (2), induction chemotherapy regimens (3), and post-remission therapy based on MST (4). Others included donor screening, infusion of donor cells, laboratory examinations, and complications of treatment

Uniaxial Compressive Constitutive Relationship of Concrete Confined by Special-Shaped Steel Tube Coupled with Multiple Cavities

A method is presented to predict the complete stress-strain curves of concrete subjected to triaxial stresses, which were caused by axial load and lateral force. The stress can be induced due to the confinement action inside a special-shaped steel tube having multiple cavities. The existing reinforced confined concrete formulas have been improved to determine the confinement action. The influence of cross-sectional shape, of cavity construction, of stiffening ribs and of reinforcement in cavities has been considered in the model. The parameters of the model are determined on the basis of experimental results of an axial compression test for two different kinds of special-shaped concrete filled steel tube (CFT) columns with multiple cavities. The complete load-strain curves of the special-shaped CFT columns are estimated. The predicted concrete strength and the post-peak behavior are found to show good agreement within the accepted limits, compared with the experimental results. In addition, the parameters of proposed model are taken from two kinds of totally different CFT columns, so that it can be concluded that this model is also applicable to concrete confined by other special-shaped steel tubes

Price Dynamics and Interactions between the Chinese and European Carbon Emission Trading Markets

The European carbon emission trading market is the largest and most mature market, while China’s carbon market has a short history. Institutionally, cross-market transaction is infeasible between the two markets. This paper investigates the long-run trend between the two markets as well as the price dynamics. Results show that a long-run trend exists between the Chinese and European carbon markets. Both markets possess self-correction capability in reducing price deviations, signaling a certain level of market efficiency. However, both markets also exhibit pricing inefficiency as historical price movements are able to impact prices. The European market informationally leads the Chinese market. Policy implications are that China should further upgrade its information disclosure system, such as unifying information disclosure standards across industries, and further develop its carbon derivatives markets to improve market transparency and market competition

Price Dynamics and Interactions between the Chinese and European Carbon Emission Trading Markets

The European carbon emission trading market is the largest and most mature market, while China’s carbon market has a short history. Institutionally, cross-market transaction is infeasible between the two markets. This paper investigates the long-run trend between the two markets as well as the price dynamics. Results show that a long-run trend exists between the Chinese and European carbon markets. Both markets possess self-correction capability in reducing price deviations, signaling a certain level of market efficiency. However, both markets also exhibit pricing inefficiency as historical price movements are able to impact prices. The European market informationally leads the Chinese market. Policy implications are that China should further upgrade its information disclosure system, such as unifying information disclosure standards across industries, and further develop its carbon derivatives markets to improve market transparency and market competition

Experimental Study on the Seismic Performance of Recycled Concrete Brick Walls Embedded with Vertical Reinforcement

Recycled concrete brick (RCB) is manufactured by recycled aggregate processed from discarded concrete blocks arising from the demolishing of existing buildings. This paper presents research on the seismic performance of RCB masonry walls to assess the applicability of RCB for use in rural low-rise constructions. The seismic performance of a masonry wall is closely related to the vertical load applied to the wall. Thus, the compressive performance of RCB masonry was investigated firstly by constructing and testing eighteen RCB masonry compressive specimens with different mortar strengths. The load-bearing capacity, deformation and failure characteristic were analyzed, as well. Then, a quasi-static test was carried out to study the seismic behavior of RCB walls by eight RCB masonry walls subjected to an axial compressive load and a reversed cyclic lateral load. Based on the test results, equations for predicting the compressive strength of RCB masonry and the lateral ultimate strength of an RCB masonry wall were proposed. Experimental values were found to be in good agreement with the predicted values. Meanwhile, finite element analysis (FEA) and parametric analysis of the RCB walls were carried out using ABAQUS software. The elastic-plastic deformation characteristics and the lateral load-displacement relations were studied

Time-Dependent Behavior of Full-Scale Recycled Aggregate Concrete Beams under Long-Term Loading

Sixteen full-scale recycled aggregate concrete (RAC) beams were cast and tested to study their time-dependent behavior under long-term loading. The test parameters include the replacement rate of the recycled coarse aggregates (RCAs), the replacement rate of the recycled fine aggregates (RFAs), the concrete strength, and the stress ratio. The influence of the above variables on the deflection and stiffness is discussed. The results show that the RCAs will increase the deflection of the specimen at a low stress ratio; at a high stress ratio, the beams will experience nonlinear creep, and the deflection of the specimen will be affected by the RCAs and the stress ratio. The RFAs have a substantial influence on the time-dependent behavior of the specimen, and the deflection of the specimen with 100% replacement of recycled aggregates can increase by 30%; the strength of the concrete does not have a substantial influence on the time-dependent behavior of the specimen; and the stress ratio has an influence on the initial deflection of the specimen. A deflection calculation formula is established based on the stress–strain relationship of the beam under long-term loading and the characteristics of the RAC. The calculation results are in good agreement with the test results