Perturbation of the sierpinski antenna to allocate the operating bands

A scheme for modifying the spacing between the bands of the Sierpinski antenna is introduced. Experimental results of two novel designs of fractal antennas suggest that the fractal structure can be perturbed to enable the log-period to be changed while still maintaining the multiband behaviour of the antenna.Peer ReviewedPostprint (published version

Small but long koch fractal monopole

A small but long wire fractal antenna based on the Koch curve is presented. Experimental and numerical results show that the antenna improves the features of a common linear monopole. The radiation resistance is increased and the Q is reduced at each fractal iteration, approaching the fundamental limit on small antennas.Peer ReviewedPostprint (published version

On the behavior of the Sierpinski multiband fractal antenna

The multiband behavior of the fractal Sierpinski antenna is described. Due to its mainly triangular shape, the antenna is compared to the well-known single-band bow-tie antenna. Both experimental and numerical results show that the self-similarity properties of the fractal shape are translated into its electromagnetic behavior. A deeper physical insight on such a behavior is achieved by means of the computed current densities over the antenna surface, which also display some similarity properties through the bands.Peer Reviewe

Technologies for Cost-Effective UDWDM-PONs

New technologies for ultradense WDM-PON (udWDM-PON), enabled by coherent techniques and low-cost devices, are developed for an efficient utilization of the optical spectrum, revealing that the 'Wavelength-to-the-User' concept can be feasible. In this paper, an udWDM-PON with only 6.25-GHz channel spacing is implemented with conventional DFB lasers, for a splitter-based PON infrastructure with 256 ONUs. The results of the analysis of udWDM access network architecture with respect to their associated complexity, cost, and migration scenarios, exhibit the potential for higher aggregate throughput, higher split ratios, and node consolidation, when compared to competing technologies

Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo

INTRODUCTION: The ras pathway is essential for cell growth and proliferation. The effects of R115777, a farnesyl transferase inhibitor, were investigated in cancer cell lines expressing varying levels of growth factor receptors and with differing ras status. Effects on tumour xenografts and human ductal carcinoma in situ (DCIS) of the breast in a xenograft mouse model were also tested. METHOD: In vitro, the concentrations required to reduce cell numbers by 50% (50% inhibitory concentration) were established (MDA-MB231, MCF-7, MCF-7/HER2-18, BT-474, SK-BR3 and SKOV3). Human DCIS was implanted in nude mice or, in separate experiments, cultured cells were injected (MDA-MB231, MCF-7/HER2-18, SKOV3) and allowed to form tumours. Proliferation and apoptosis were determined by immunohistochemistry in xenografts and cell tumours. RESULTS: The 50% inhibitory concentrations varied a hundred-fold, from 39 nmol/l (± 26 nmol/l) for SKBR3 to 5.9 μmol/l(± 0.8 μmol/l) for MDA-MB231. In MCF-7/HER2-18 and SKOV3 cells the levels of tumour growth inhibition were approximately 85% and 40%, respectively. There was a significant decrease in the cell turnover index (CTI; proliferation/apoptosis). In MDA-MB 231 with activated k-ras no inhibition was observed. In treated DCIS xenografts proliferation decreased and apoptosis increased. The CTI ratio between the start and 1 and 2 weeks of treatment were 1.99 and 1.50, respectively, for controls and 0.85 (P = 0.005) and 0.75 (P = 0.08) for treated xenografts. CONCLUSION: Treatment with the farnesyl transferase inhibitor reduced cell growth in vitro and cell tumour growth in vivo. In DCIS treatment resulted in a reduced CTI. R115777 is a promising treatment for breast cancer but the relation between effect and growth factor receptor and ras status has to be established

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway

16 pages, 10 figures, supplementary information https://doi.org/10.1038/s41467-023-39051-x.-- Data availability: The diffraction data and coordinates of the p38α complexes bound to NC-p38i compounds have been deposited in the Protein Data Bank under accession codes 7PVU, 7Z6I and 7Z9T. We have also used the following PDB structures: 4LOO, 1A9U, 3COI, 7N8T, 2ZOQ, 1PME, 3GC9, 1CM8, 4UX9. Source data are provided with this paperp38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α signaling has been linked to several diseases including inflammation, immune disorders and cancer, suggesting that targeting p38α could be therapeutically beneficial. Over the last two decades, numerous p38α inhibitors have been developed, which showed promising effects in pre-clinical studies but results from clinical trials have been disappointing, fueling the interest in the generation of alternative mechanisms of p38α modulation. Here, we report the in silico identification of compounds that we refer to as non-canonical p38α inhibitors (NC-p38i). By combining biochemical and structural analyses, we show that NC-p38i efficiently inhibit p38α autophosphorylation but weakly affect the activity of the canonical pathway. Our results demonstrate how the structural plasticity of p38α can be leveraged to develop therapeutic opportunities targeting a subset of the functions regulated by this pathwayThis work was supported by grants from the Spanish Ministerio de Ciencia e Innovación (MICINN, PID2019-109521RB-I00 and PID2021-122478NB-I00), the BioMedTec program of IRB-Fundació La Caixa, the European Research Council (Proof of Concept p38_InTh-825763), AGAUR (2016 LLAV 00043 and 2019 PROD 00138 supported by FEDER, and 2017 SGR-557, 2017 SGR-50, 2021 SGR-909, and 2021 SGR-866), BBVA Foundation, and the European Union’s Horizon 2020 research and innovation program (euCanSHare 825903 and BioExcel-3 101093290). L.G. and B.B. were funded by predoctoral contracts from MICINN (BES-2016-077122) and the Marie Skłodowska-Curie COFUND action of IRB Barcelona and the PREBIST Predoc Programme (PREBIST_754558), respectively. F.C. is a Ramon y Cajal Fellow (RYC2019-026768-I). Access to ALBA was granted through the BAG proposals 2018092972 and 2020094472. We gratefully acknowledge institutional funding from IRB Barcelona, the CERCA Programme of the Catalan Government, and the MICINN through the Centres of Excellence Severo Ochoa award. M.J.M. and A.R.N. are supported by the Institució Catalana de Recerca i Estudis Avancats (ICREA)With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewe

Efecto de la variación angular en el vértice de alimentación de la antena fractal de Sierpinski

Peer ReviewedPostprint (published version

On the behavior of the Sierpinski multiband fractal antenna

The multiband behavior of the fractal Sierpinski antenna is described. Due to its mainly triangular shape, the antenna is compared to the well-known single-band bow-tie antenna. Both experimental and numerical results show that the self-similarity properties of the fractal shape are translated into its electromagnetic behavior. A deeper physical insight on such a behavior is achieved by means of the computed current densities over the antenna surface, which also display some similarity properties through the bands.Peer Reviewe