Solving the Solar Neutrino Problem 2 km Underground -- the Sudbury Neutrino Observatory

The Sudbury Neutrino Observatory (SNO) is capable of measuring simultaneously the flux of electron-type neutrinos and the total flux of all active flavours of neutrinos originating from the Sun. A model-independent test of neutrino flavour transformation was performed by comparing these two measurements. Assuming an undistorted neutrino energy spectrum, this transformation has been definitively demonstrated in the pure D2O phase of the SNO experiment. In the second phase with dissolved NaCl in the D2O, the total active solar neutrino flux was measured without any assumption on the energy dependence of flavour transformation. In this talk, results from these measurements, their physics implications and the current status of the SNO experiment are presented.Comment: Proceedings of the 8th ICATPP Conference on Astroparticle, Particle, Space Physics, Detectors and Medical Physics Applications (Como, Italy, Oct 6-10, 2003) 10 pages, 3 figures, 2 table

Recent Results from the Sudbury Neutrino Observatory

The Sudbury Neutrino Observatory (SNO) measures both the flux of the electron-type neutrinos and the total flux of all active flavours of neutrinos originating from the Sun. A model-independent test of neutrino flavour transformation was performed by comparing these two measurements. In 2002, this flavour transformation was definitively demonstrated. In this talk, results from these measurements and the current status of the SNO detector are presented.Comment: Proceedings of the International Europhysics Conference on High Energy Physics (EPS2003) 3 pages, 2 figures, 2 table

Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter

BACKGROUND. Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation. OBJECTIVE. We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) and in diastolic blood pressure (ΔDBP) and that this effect is modified by genes thought to be related to chronic lung disease. METHODS. We measured blood pressure in participants every 3-5 years. ΔSBP and ΔDBP were calculated as sitting minus standing SBP and DBP. We averaged PM2.5 over 48 hr before study visits and analyzed 202 single nucleotide polymorphisms (SNPs) in 25 genes. To address multiple comparisons, data were stratified into a split sample. In the discovery cohort, the effects of SNP x PM2.5 interactions on ΔSBP and ΔDBP were analyzed using mixed models with subject-specific random intercepts. We defined positive outcomes as p < 0.1 for the interaction; we analyzed only these SNPs in the replicate cohort and confirmed them if p < 0.025 with the same sign. Confirmed associations were analyzed within the full cohort in models adjusted for anthropometric and lifestyle factors. RESULTS. Nine hundred forty-five participants were included in our analysis. One interaction with rs9568232 in PHD finger protein 11 (PHF11) was associated with greater ΔDBP. Interactions with rs1144393 in matrix metalloprotease 1 (MMP1) and rs16930692, rs7955200, and rs10771283 in inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) were associated with significantly greater ΔSBP. Because SNPs associated with ΔSBP in our analysis are in genes along the renin-angiotensin pathway, we then examined medications affecting that pathway and observed significant interactions for angiotensin receptor blockers but not angiotensin-converting enzyme inhibitors with PM2.5. CONCLUSIONS. PM2.5 influences blood pressure and autonomic function. This effect is modified by genes and drugs that also act along this pathway.National Institute of Environmental Health Sciences (T32 ES07069, ES0002, ES015172-01, ES014663, P01 ES09825); United States Environmental Protection Agency (R827353, R832416); National Institutes of Health/National Institute of Aging (AG027014); United States Department of Veterans Affairs; Massachusetts Veterans Epidemiology Research and Information Cente

Potential one-forms for hyperk\"ahler structures with torsion

It is shown that an HKT-space with closed parallel potential 1-form has $D(2,1;-1)$-symmetry. Every locally conformally hyperk\"ahler manifold generates this type of geometry. The HKT-spaces with closed parallel potential 1-form arising in this way are characterized by their symmetries and an inhomogeneous cubic condition on their torsion.Comment: 16 pages, Latex, no figure

Transmission and group delay of microring coupled-resonator optical waveguides

We measured the transmission and group delay of microring coupled-resonator optical waveguides (CROWs). The CROWs consisted of 12 weakly coupled, microring resonators fabricated in optical polymers (PMMA on Cytop). The intrinsic quality factor of the resonators was 18,000 and the interresonator coupling was 1%, resulting in a delay of 110-140 ps and a slowing factor of 23-29 over a 17 GHz bandwidth

Polymer Microring Coupled-Resonator Optical Waveguides

We present measurements of the transmission and dispersion properties of coupled-resonator optical waveguides (CROWs) consisting of weakly coupled polymer microring resonators. The fabrication and the measurement methods of the CROWs are discussed as well. The experimental results agree well with the theoretical loss, waveguide dispersion, group delay, group velocity, and group-velocity dispersion (GVD). The intrinsic quality factors of the microrings were about 1.5 times 10^4 to 1.8 times 10^4, and group delays greater than 100 ps were measured with a GVD between -70 and 100 ps/(nm x resonator). With clear and simple spectral responses and without a need for the tuning of the resonators, the polymer microring CROWs demonstrate the practicability of using a large number of microresonators to control the propagation of optical waves

Randomized crossover comparison of proportional assist ventilation and patient-triggered ventilation in extremely low birth weight infants with evolving chronic lung disease

Background: Refinement of ventilatory techniques remains a challenge given the persistence of chronic lung disease of preterm infants. Objective: To test the hypothesis that proportional assist ventilation ( PAV) will allow to lower the ventilator pressure at equivalent fractions of inspiratory oxygen (FiO(2)) and arterial hemoglobin oxygen saturation in ventilator-dependent extremely low birth weight infants in comparison with standard patient-triggered ventilation ( PTV). Methods: Design: Randomized crossover design. Setting: Two level-3 university perinatal centers. Patients: 22 infants ( mean (SD): birth weight, 705 g ( 215); gestational age, 25.6 weeks ( 2.0); age at study, 22.9 days ( 15.6)). Interventions: One 4- hour period of PAV was applied on each of 2 consecutive days and compared with epochs of standard PTV. Results: Mean airway pressure was 5.64 ( SD, 0.81) cm H2O during PAV and 6.59 ( SD, 1.26) cm H2O during PTV ( p < 0.0001), the mean peak inspiratory pressure was 10.3 ( SD, 2.48) cm H2O and 15.1 ( SD, 3.64) cm H2O ( p < 0.001), respectively. The FiO(2) ( 0.34 (0.13) vs. 0.34 ( 0.14)) and pulse oximetry readings were not significantly different. The incidence of arterial oxygen desaturations was not different ( 3.48 ( 3.2) vs. 3.34 ( 3.0) episodes/ h) but desaturations lasted longer during PAV ( 2.60 ( 2.8) vs. 1.85 ( 2.2) min of desaturation/ h, p = 0.049). PaCO2 measured transcutaneously in a subgroup of 12 infants was similar. One infant met prespecified PAV failure criteria. No adverse events occurred during the 164 cumulative hours of PAV application. Conclusions: PAV safely maintains gas exchange at lower mean airway pressures compared with PTV without adverse effects in this population. Backup conventional ventilation breaths must be provided to prevent apnea-related desaturations. Copyright (c) 2007 S. Karger AG, Base