Models of assessment of the influence of insurance assets securitization on stability of mutual insurance societies

The article reviews approaches to assessing the effectiveness of the mechanism of insurance assets securitization used to enhance the financial stability of the mutual insurance society, determined by the level of probability of its default. The approaches are based on the methods of simulation modeling of the financial flows of the society formed taking into account the patterns of random payments, deterministic premiums, proceeds and securitization costs. Following the results of a series of simulation experiments, the peculiarities of the influence of securitization on stability of a MIS are identified, and recommendations for its use are justified. The estimates of the costs of structuring the transaction are obtained, based on which a certain minimum volumes of securitization are determined, at which its use is appropriate.peer-reviewe

Economic concept of food development of Russian market

At present, the Russian economy is developing in the conditions of imposed sanctions on high-tech means of production by foreign countries. In this situation, the development vector is the formation of import substitution policies and the solution of food safety issues for various types of food products that are strategically important for human life. Meeting the needs of the country's population with its own production is a priority for the development of the agrarian market, which makes it possible to develop the production agrarian sector, the processing and trade sphere, to create additional jobs, thereby improving the quality and standard of living of people.peer-reviewe

Performance and application of heavy ion nuclear microbeam facility at the Nuclear Physics Institute in Řež, Czech Republic

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Magnetic Field Stimulated Transitions of Excited States in Fast Muonic Helium Ions

It is shown that one can stimulate, by using the present-day laboratory magnetic fields, transitions between the $lm$ sub-levels of fast $\mu He^+$ ions formating in muon catalyzed fusion. Strong fields also cause the self-ionization from highly excited states of such muonic ions. Both effects are the consequence of the interaction of the bound muon with the oscillating field of the Stark term coupling the center-of-mass and muon motions of the $\mu He^+$ ion due to the non-separability of the collective and internal variables in this system. The performed calculations show a possibility to drive the population of the $lm$ sub-levels by applying a field of a few $Tesla$, which affects the reactivation rate and is especially important to the $K\alpha$ $x$-ray production in muon catalyzed fusion. It is also shown that the $2s-2p$ splitting in $\mu He^+$ due to the vacuum polarization slightly decreases the stimulated transition rates.Comment: 5 figure

Post‐COVID worsening of a Parkinson's disease patient

Abstract Worsening of clinical symptoms after COVID‐19 infection and misregulation of CD4 and CD8 T‐cell numbers may be revealed in PD patients. Immunological changes may be a source of clinical worsening of the patient

Development of a New Reporter Gene System-dsRed/Xanthine Phosphoribosyltransferase-Xanthine for Molecular Imaging of Processes Behind the Intact Blood-Brain Barrier

We report the development of a novel dual-modality fusion reporter gene system consisting of Escherichia coli xanthine phosphoribosyltransferase (XPRT) for nuclear imaging with radiolabeled xanthine and Discosoma red fluorescent protein for optical fluorescent imaging applications. The dsRed/XPRT fusion gene was successfully created and stably transduced into RG2 glioma cells, and both reporters were shown to be functional. The level of dsRed fluorescence directly correlated with XPRT enzymatic activity as measured by ribophosphorylation of [ 14 C]-xanthine was in vitro ( K i = 0.124 ± 0.008 vs. 0.00031 ± 0.00005 mL/min/g in parental cell line), and [ * ]-xanthine octanol/water partition coefficient was 0.20 at pH = 7.4 (log P = 0.69), meeting requirements for the blood-brain barrier (BBB) penetrating tracer. In the in vivo experiment, the concentration of [* C]-xanthine in the normal brain varied from 0.20 to 0.16 + 0.05% dose/g under 0.87 + 0.24% dose/g plasma radiotracer concentration. The accumulation in vivo in the transfected flank tumor was to 2.4 ± 0.3% dose/g, compared to 0.78 ± 0.02% dose/g and 0.64 ± 0.05% dose/g in the control flank tumors and intact muscle, respectively. [ 14 C]-Xanthine appeared to be capable of specific accumulation in the transfected infiltrative brain tumor (RG2-dsRed/XPRT), which corresponded to the 585 nm fluorescent signal obtained from the adjacent cryosections. The images of endogenous gene expression with the “sensory system” have to be normalized for the transfection efficiency based on the “beacon system” image data. Such an approach requires two different “reporter genes” and two different “reporter substrates.” Therefore, the novel dsRed/XPRT fusion gene can be used as a multimodality reporter system in the biological applications requiring two independent reporter genes, including the cells located behind the BBB