Correction of adma-induced preeclampsia with the use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010

Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation in the placenta, the violation of the regulation of vascular tone and destructive changes in the ischemic placenta. The use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010 leads to the expression of morphological and functional correction of violations occurring in modeling of experimental preeclampsi

Integrated evaluation of the endothelioprotective activity of an innovative peptide simulating the alpha-helix of B-erythropoethin in L-name-induced nitrogen oxide deficiency at the late gestation period

To study the efficiency of using carbamylated darbepoetin, asialized erythropoietin and an 11-amino acid peptide that simulating the spatial structure of the B-erythropoietin alpha-helix in the correction of L-NAME-induced nitric oxide deficiency in the late gestation perio

Management of chronic obstructive pulmonary disease

This study aimed to determine the level of senior medical students’ knowledge in the management of patients with COPD, based on the method of anonymous questioning. This research work describes the results of the second stage of the ASCO project (Assessment of Senior Medical Students in the Field of COPD) conducted in 2017-2019 among 338 senior medical students from six large cities of Russia and Ukrain

Erythropoietin mimetic peptide (pHBSP) corrects endothelial dysfunction in a rat model of preeclampsia

Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunctio

Studies to Elucidate the Effects of Furostanol Glycosides from Dioscorea deltoidea Cell Culture in a Rat Model of Endothelial Dysfunction

Currently, there is no doubt surrounding a theory that the cardiotropic e ects of sex hormones can be due to their direct e ect on the cardiovascular system. In recent years, interest in the study of steroid glycosides has increased. We studied the e ects of furostanol glycosides (protodioscin and deltozid) from the cell culture of the Dioscorea deltoidea (laboratory code DM-05) on the physiological and biochemical parameters of vascular endothelial function in hypoestrogen-induced endothelial dysfunction after bilateral ovariectom

Study of the selective phenolic inhibitors of arginase 2 acute toxicity

We have previously shown that the isolated arginase 2 inhibitors have a pronounced endothelioprotective level. A strategy is proposed for the targeted search for isolated arginase 2 inhibitors among compounds of a phenolic nature. Received 3 compounds, isolated arginase inhibitors 2. As a result of the study, the acute toxicity of the compounds obtained was studie

Eleven-amino acid peptides that mimic the erythropoietin α-helix B increases cell survival in endotheliocyte culture

To study the cytoprotective activity of peptides that mimic the spatial structure of the erythropoietin α-helix B in vitr

Erythropoietin mimetic peptide (pHBSP) corrects endothelial dysfunction in a rat model of preeclampsia

Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therap

Correction of adma-induced preeclampsia with the use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010

Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation in the placenta, the violation of the regulation of vascular tone and destructive changes in the ischemic placenta. The use of phosphodiesterase 5 and selective inhibitor of arginase II ZB49-0010 leads to the expression of morphological and functional correction of violations occurring in modeling of experimental preeclampsi

The anti-aggregation activity of new 11-amino acid of erythropoietin derivate containing tripeptide motifs

To study the platelet antiaggregant activity of new 11-amino acid derivatives of erythropoietin, containing tripeptide motif