GET_MOVE: An Efficient and Unifying Spatio-Temporal Pattern Mining Algorithm for Moving Objects

International audienceRecent improvements in positioning technology has led to a much wider availability of massive moving object data. A crucial task is to find the moving objects that travel together. Usually, they are called spatio-temporal pat- terns. Due to the emergence of many different kinds of spatio-temporal patterns in recent years, different approaches have been proposed to extract them. However, each approach only focuses on mining a specific kind of pattern. In addition to the fact that it is a painstaking task due to the large number of algorithms used to mine and manage patterns, it is also time consuming. Additionally, we have to execute these algorithms again whenever new data are added to the existing database. To address these issues, we first redefine spatio-temporal patterns in the itemset context. Secondly, we propose a unifying approach, named GeT Move, using a frequent closed itemset-based spatio-temporal pattern-mining algorithm to mine and manage different spatio-temporal patterns. GeT Move is implemented in two versions which are GeT Move and Incremental GeT Move. Experiments are per- formed on real and synthetic datasets and the experimental results show that our approaches are very effective and outperform existing algorithms in terms of efficiency

Mining Multi-Relational Gradual Patterns

International audienceGradual patterns highlight covariations of attributes of the form " The more/less X, the more/less Y ". Their usefulness in several applications has recently stimulated the synthesis of several algorithms for their automated discovery from large datasets. However, existing techniques require all the interesting data to be in a single database relation or table. This paper extends the notion of gradual pattern to the case in which the co-variations are possibly expressed between attributes of different database relations. The interestingness measure for this class of " relational gradual patterns " is defined on the basis of both Kendall's τ and gradual supports. Moreover, this paper proposes two algorithms, named τ RGP Miner and gRGP Miner, for the discovery of relational gradual rules. Three pruning strategies to reduce the search space are proposed. The efficiency of the algorithms is empirically validated, and the usefulness of relational gradual patterns is proved on some real-world databases

M^2UNet: MetaFormer Multi-scale Upsampling Network for Polyp Segmentation

Polyp segmentation has recently garnered significant attention, and multiple methods have been formulated to achieve commendable outcomes. However, these techniques often confront difficulty when working with the complex polyp foreground and their surrounding regions because of the nature of convolution operation. Besides, most existing methods forget to exploit the potential information from multiple decoder stages. To address this challenge, we suggest combining MetaFormer, introduced as a baseline for integrating CNN and Transformer, with UNet framework and incorporating our Multi-scale Upsampling block (MU). This simple module makes it possible to combine multi-level information by exploring multiple receptive field paths of the shallow decoder stage and then adding with the higher stage to aggregate better feature representation, which is essential in medical image segmentation. Taken all together, we propose MetaFormer Multi-scale Upsampling Network (M$^2$UNet) for the polyp segmentation task. Extensive experiments on five benchmark datasets demonstrate that our method achieved competitive performance compared with several previous methods

Co2Vis: A Visual Analytics Tool for Mining Co-Expressed and Co-Regulated Genes Implied in HIV Infections

International audienceOne of the key challenges in human health is the identification of disease-causing genes like AIDS (Acquired ImmunoDeficiency Syndrome). Numerous studies have addressed this challenge through gene expression analysis. Due to the amount of data available, processing DNA microarrays in a way that makes biomedical sense is still a major issue.Statistical methods and data mining techniques play a key role in discovering previously unknown knowledge. However, applying such techniques in this context is difficult because the number of measurement points (i.e., gene expression levels) is much higher than the number of samples resulting in the well-known curse of dimensionality problem also called the high feature-to-sample ratio.We propose a combination of data mining and visual analytics methods to identify and render groups of genes implied in HIV infections and sharing common behaviors

How to Extract Relevant Knowledge from Tweets?

[Departement_IRSTEA]Territoires [TR1_IRSTEA]SYNERGIE [Axe_IRSTEA]TETIS-SISOInternational audienceTweets exchanged over the Internet are an important source of information even if their characteristics make them difficult to analyze (e.g., a maximum of 140 characters; noisy data). In this paper, we investigate two different problems. The first one is related to the extraction of representative terms from a set of tweets. More precisely we address the following question: are traditional information retrieval measures appropriate when dealing with tweets?. The second problem is related to the evolution of tweets over time for a set of users. With the development of data mining approaches, lots of very efficient methods have been defined to extract patterns hidden in the huge amount of data available. More recently new spatio-temporal data mining approaches have specifically been defined for dealing with the huge amount of moving object data that can be obtained from the improvement in positioning technology. Due to particularity of tweets, the second question we investigate is the following: are spatio-temporal mining algorithms appropriate for better understanding the behavior of communities over time? These two prob- lems are illustrated through real applications concerning both health and political tweets

Heart rate variability measured from wearable devices as a marker of disease severity in tetanus

Tetanus is a disease associated with significant morbidity and mortality. Heart rate variability (HRV) is an objective clinical marker with potential value in tetanus. This study aimed to investigate the use of wearable devices to collect HRV data and the relationship between HRV and tetanus severity. Data were collected from 110 patients admitted to the intensive care unit in a tertiary hospital in Vietnam. HRV indices were calculated from 5-minute segments of 24-hour electrocardiogram recordings collected using wearable devices. HRV was found to be inversely related to disease severity. The standard deviation of NN intervals and interquartile range of RR intervals (IRRR) were significantly associated with the presence of muscle spasms; low frequency (LF) and high frequency (HF) indices were significantly associated with severe respiratory compromise; and the standard deviation of differences between adjacent NN intervals, root mean square of successive differences between normal heartbeats, LF to HF ratio, total frequency power, and IRRR, were significantly associated with autonomic nervous system dysfunction. The findings support the potential value of HRV as a marker for tetanus severity, identifying specific indices associated with clinical severity thresholds. Data were recorded using wearable devices, demonstrating this approach in resource-limited settings where most tetanus occurs

An open label randomized controlled trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis

Background: Cryptococcal meningitis has high mortality. Flucytosine is a key treatment but is expensive and rarely available. The anti-cancer agent tamoxifen has synergistic anti-cryptococcal activity with amphotericin in vitro. It is off-patent, cheap, and widely available. We performed a trial to determine its therapeutic potential. Methods:Open label randomized controlled trial. Participants received standard care - amphotericin combined with fluconazole for the first two weeks - or standard care plus tamoxifen 300mg/day. The primary end point was Early Fungicidal Activity (EFA) - the rate of yeast clearance from cerebrospinal fluid (CSF). Trial registration https://clinicaltrials.gov/ct2/show/NCT03112031 . Results: 50 patients were enrolled, (median age 34 years, 35 male). Tamoxifen had no effect on EFA (- 0.48log10 colony-forming units/mL/CSF control arm versus -0.49 tamoxifen arm, difference - 0.005log10CFU/ml/day, 95%CI: -0.16, 0.15, P=0.95). Tamoxifen caused QTc prolongation. Conclusion: High dose tamoxifen does not increase the clearance rate of Cryptococcus from CSF. Novel, affordable therapies are needed. Funding:The trial was funded through the Wellcome Trust Asia Programme Vietnam Core Grant 106680 and a Wellcome Trust Intermediate Fellowship to JND grant number WT097147MA

Awareness and preparedness of healthcare workers against the first wave of the COVID-19 pandemic: A cross-sectional survey across 57 countries.

BACKGROUND: Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave. METHODS: This multinational, multicenter, cross-sectional survey was conducted among hospital HCWs from February to May 2020. We used a hierarchical logistic regression multivariate analysis to adjust the influence of variables based on awareness and preparedness. We then used association rule mining to identify relationships between HCW confidence in handling suspected COVID-19 patients and prior COVID-19 case-management training. RESULTS: We surveyed 24,653 HCWs from 371 hospitals across 57 countries and received 17,302 responses from 70.2% HCWs overall. The median COVID-19 preparedness score was 11.0 (interquartile range [IQR] = 6.0-14.0) and the median awareness score was 29.6 (IQR = 26.6-32.6). HCWs at COVID-19 designated facilities with previous outbreak experience, or HCWs who were trained for dealing with the SARS-CoV-2 outbreak, had significantly higher levels of preparedness and awareness (p<0.001). Association rule mining suggests that nurses and doctors who had a 'great-extent-of-confidence' in handling suspected COVID-19 patients had participated in COVID-19 training courses. Male participants (mean difference = 0.34; 95% CI = 0.22, 0.46; p<0.001) and nurses (mean difference = 0.67; 95% CI = 0.53, 0.81; p<0.001) had higher preparedness scores compared to women participants and doctors. INTERPRETATION: There was an unsurprising high level of awareness and preparedness among HCWs who participated in COVID-19 training courses. However, disparity existed along the lines of gender and type of HCW. It is unknown whether the difference in COVID-19 preparedness that we detected early in the pandemic may have translated into disproportionate SARS-CoV-2 burden of disease by gender or HCW type