Data communications and monitor for the Penn State University profiler network

The profiler network installed by the Department of Meteorology at Penn State University utilizes a microcomputer for network monitoring and control. The network consists of two VHF and one UHF wind profiling Doppler radars. Additional measurement systems added to the network include temperature and humidity profiling radiometers, sodar for boundary layer wind profiling and selected surface based baseline systems. Remote diagnostic capabilities were also implemented in the Penn State network. It is possible to remotely analyze many specific malfunctions of the transmitter or signal processor

Tertiary lymphoid organs in central nervous system autoimmunity

Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients. Autoreactive T cells are important drivers of the disease; however, the efficacy of B cell depleting therapies uncovered an essential role for B cells in disease pathogenesis. They can contribute to inflammatory processes via presentation of autoantigen, secretion of pro-inflammatory cytokines, and production of pathogenic antibodies. Recently, B cell aggregates reminiscent of tertiary lymphoid organs (TLOs) were discovered in the meninges of MS patients, leading to the hypothesis that differentiation and maturation of autopathogenic B and T cells may partly occur inside the CNS. Since these structures were associated with a more severe disease course, it is extremely important to gain insight into the mechanism of induction, their precise function, and clinical significance. Mechanistic studies in patients are limited. However, a few studies in the MS animal model experimental autoimmune encephalomyelitis (EAE) recapitulate TLO formation in the CNS and provide new insight into CNS TLO features, formation, and function. This review summarizes what we know so far about CNS TLOs in MS and what we have learned about them from EAE models. It also highlights the areas that are in need of further experimental work, as we are just beginning to understand and evaluate the phenomenon of CNS TLOs

Relationship between antihypertensive medications and cognitive impairment: Part II. Review of Physiology and animal studies

Purpose of Review There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are less clear. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews provide comprehensive review. Our extensive review includes 24 mechanistic animal and human studies published over the last 5 years assessing relationship between AHM and cognitive function. Recent Findings All classes of AHM showed similar result patterns in animal studies. The mechanism by which AHM exert their effect was extensively studied by evaluating well-established pathways of AD disease process, including amyloid beta (Aβ), vascular, oxidative stress and inflammation pathways, but only few studies evaluated the blood pressure lowering effect on the AD disease process. Summary Methodological limitations of the studies prevent comprehensive conclusions prior to further work evaluating AHM in animals and larger human observational studies, and selecting those with promising results for future RCTs

Simulating Organogenesis in COMSOL: Tissue Mechanics

During growth, tissue expands and deforms. Given its elastic properties, stresses emerge in an expanding and deforming tissue. Cell rearrangements can dissipate these stresses and numerous experiments confirm the viscoelastic properties of tissues [1]-[4]. On long time scales, as characteristic for many developmental processes, tissue is therefore typically represented as a liquid, viscous material and is then described by the Stokes equation [5]-[7]. On short time scales, however, tissues have mainly elastic properties. In discrete cell-based tissue models, the elastic tissue properties are realized by springs between cell vertices [8], [9]. In this article, we adopt a macroscale perspective of tissue and consider it as homogeneous material. Therefore, we may use the "Structural Mechanics" module in COMSOL Multiphysics in order to model the viscoelastic behavior of tissue. Concretely, we consider two examples: first, we aim at numerically reproducing published [10] analytical results for the sea urchin blastula. Afterwards, we numerically solve a continuum mechanics model for the compression and relaxation experiments presented in [4]

Creative Commons Licenses: empowering open access

No abstract available

Relationship between antihypertensive medications and cognitive impairment: Part I. review of human studies and clinical trials

Purpose of review: There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews are comprehensive. Our extensive review includes 15 observational and randomized controlled trials (RCTs) published over the last 5 years, assessing the relationship between AHM and cognitive impairment. Recent findings: All classes of AHM showed similar result patterns in human studies with the majority of study results reporting point estimates below one and only a small number of studies (N = 15) reporting statistically significant results in favor of a specific class. Summary: Only a small number of studies reported statistically significant results in favor of a specific class of AHM. Methodological limitations of the studies prevent definitive conclusions. Further work is now needed to evaluate the class of AHM and cognitive outcomes in future RCTs, with a particular focus on the drugs with the promising results in both animals and human observational studies