Surgical correction of the wolff-parkinson-white syndrome in the closed heart using cryosurgery: A simplified approach

The conventional operation for ablation of accessory atrioventricular (AV) pathways in the Wolff-Parkinson-White syndrome requires an endocardial approach to the AV groove and necessitates the use of cardiopulmonary bypass and induced cardiac arrest. The feasibility of creating transmural atrial fibrosis at the level of the AV anulus in the closed heart in dogs without damaging the vascular contents of the AV fat pad was demonstrated. This was done by dissecting the fat pad from the atrium and applying a cryoprobe to the exposed atrial-anular region after retraction of the fat pad. The technique was then applied to successfully ablate 12 left parietal wall accessory pathways in 11 patients with the Wolff-Parkinson-White syndrome. This simplified approach to any parietal wall accessory pathway does not require cardiopulmonary bypass or induced cardiac arrest and may broaden the indications for this operation

The High Voltage Feedthroughs for the ATLAS Liquid Argon Calorimeters

The purpose, design specifications, construction techniques, and testing methods are described for the high voltage feedthrough ports and filters of the ATLAS Liquid Argon calorimeters. These feedthroughs carry about 5000 high voltage wires from a room-temperature environment (300 K) through the cryostat walls to the calorimeters cells (89 K) while maintaining the electrical and cryogenic integrity of the system. The feedthrough wiring and filters operate at a maximum high voltage of 2.5 kV without danger of degradation by corona discharges or radiation at the Large Hadron Collider

2020-06-26/27/28 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: State fair cancelled. Phase 2 reopening stalls. Fewer New Mexicans staying home. ABQ July 4 celebration plan. NM case update. US Highlights: Family members infected following surprise birthday party. New cases spike in Texas due to early reopening of bars. International Highlights: 50% in Austria ski resort have antibodies. Economics, Workforce, Supply Chain, PPE: Why people do not wear masks. Mask filtration efficiencies compared. Masks worn incorrectly. Ultraviolet-based biophotonic technologies. Improved mask designs. Mask wearing controversy. Epidemiology Highlights: Contamination through air flow paths. Contamination of wastewater circulation. Healthcare Policy Recommendations: Moralizing COVID-19 mitigation practices contributes to social polarization. Misperception of exponential infection growth by Americans is common but can be corrected. Adjust quarantine plans for the findings that older patients might have a longer incubation period. Hazards of school reopening in European countries with high transmission rates. Practice Guidelines: Several Brazilian recommendations are published on managing lung cancer, performing laparoscopic surgery, and breastfeeding. Guidelines are provided and managing gynecological cancer. Testing: Test accessibility, frequency and speed of reporting matters more than sensitivity. Prolonged shedding of SARS-CoV-2. Sensitivity of nasopharyngeal and swabs testing. Testing algorithm for essential workers. Drugs, Vaccines, Therapies, Clinical Trials: dexamethasone trial preprint criticized, smallpox-based COVID-19 vaccine, 27 new clinical trials. Other Science: Pandemic sees increased alcohol consumption. Charlson Comorbidity Index predicts poor outcomes. CT features associated with severity. Immune-inflammatory tests associated with severity. Hepatic complications

2020-05-29/30/31 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM case count. Navajo Nation case update. Largest COVID-19 surge in Taos. ABQ BioPark to reopen. NM public schools reopening plan. NM unemployment claims. Rise in domestic and sexual abuse. US Highlights: Protests inspire fear of surge. Trump withdraws from WHO. Last aid bill. No new NY patients. ICE detainees sick. International Highlights: South Korea schools close. Undercounting in Russia. South African overburdened health care system. Economics, Workforce, Supply Chain, PPE: Reusable protection system. Protective household products. Longterm economic challenges. Epidemiology Highlights: Estimate virus reproduction numbers. Hypertension & cardiovascular disease impact on mortality. Gastrointestinal manifestations. Healthcare Policy Recommendations: Immunity passports are bad idea. Evaluation of hand WHO-recommended products. Opioid use-related challenges of COVID-19 management. Practice Guidelines: NICE guidelines on COVID-19 and acute kidney injury. Example of rapid conversion of an outpatient psychiatric hospital to a virtual telepsychiatry clinic. JAMA recommendations on conducting and reporting COVID-19 clinical research. Testing: Comparison of 4 antigen tests. Validation of antibody assays. Drugs, Vaccines, Therapies, Clinical Trials: Encouraging results of Ruxolitinib phase II RCT. Benefits of adjunctive herbal medicine. Potential inhibitors of viral protease screened. Anticoagulation alone is unlikely to protect from COVID-19 related morbidity and mortality. Open access database Covid19db for COVID-19 drugs. 49 new trials registered. Other Science: COVID-19 collateral damage. Telomere length and COVID-19 outcomes. Wastewater RNA early warning. Neurologic manifestation review. MRI reveals predominant anosmia cases. Self-quarantine weight gain. Immunosuppression vs. cytokine storm. Combatting misinformation

2020-04-06 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM case updates. Several NM policy and legislative actions. Federal vs. state conflict over medical supply lines. Healthcare workers sleep in cars to prevent family exposure. Same-day in-house testing at Cedars-Sinai. Debate over hydroxychloroquine Tx. Death rate differences: Germany and Italy. African innovations. Testing recommended with mild symptoms. CDC guidelines for law enforcement PPE. New WHO first responder training and CDC sign language resources. COVID-19 droplets can travel up to 27 feet. Transmission from the asymptomatic. Humidifiers help. Drug and vaccine progress

2020-06-15/16 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM case updates. Tribal outreach campaign. Santa Fe firefighters support first responders. US Highlights: COVID-19 hospitalizations rise in Texas. US retail sales up in May. Projected COVID-19 deaths in US. International Highlights: COVID-19 prevention and control in Africa. COVID-19 response and challenge in Africa. Epidemiology Highlights: Herd immunity in Europe. Social distance measures effects. Modeling infections in India. Fecal analysis. Wastewater-based Epidemiology Consortium. Healthcare Policy Recommendations: Public health approach to lockdown debate. All of Us Program adds new COVID-19 initiatives. Practice Guidelines: Guidelines are reviewed on urology care. IBD endoscopy. Convalescent plasma use. Testing: Patient predictors of risk for positive COVID-19 test are reported and an online risk calculator is now available. Drugs, Vaccines, Therapies, Clinical Trials: Steroid dexamethasone reduces 28-day mortality by 1/3. Research links ‘inflamm-aging’ and cytokine storm in elderly. Cancer drug may reduce severe COVID-19. 48 new trials registered. Other Science: Postpone surgery. Proteins predict outcomes. Neurologic manifestations. Thromboembolic risk. Zoonotic transmission. Liver failure. Cardiac complications