Identification of polymorphisms explaining a linkage signal: application to the GAW14 simulated data-0

<p><b>Copyright information:</b></p><p>Taken from "Identification of polymorphisms explaining a linkage signal: application to the GAW14 simulated data"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S88-S88.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866692.</p><p></p>l dotted line (-log0.05)

HST -values are below the diagonal; TRANSMIT -values are above; estimated minor allele frequencies are on the left margin

<p><b>Copyright information:</b></p><p>Taken from "Identification of polymorphisms explaining a linkage signal: application to the GAW14 simulated data"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S88-S88.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866692.</p><p></p> The square identified by "i" represents the imost significant (by both HST and TRANSMIT) SNP pair ranked by the sum of the TRANSMIT and HST -values. For example, in the top panel, "3" (in the first row) means that HST and TRANSMIT -values for pair B8321–B8341 are both significant and the sum of their -values is the third most significant. Hj and Tj represent the jsignificant SNP pair by HST and TRANSMIT, respectively. Note, on the top panel, "2"-H2, "3"-H3 coincide; only "2" and "3" are identified. Similarly for the bottom panel, "4"-T5, "6"-H4 coincide and only "4" and "6" are identified

Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene-0

<p><b>Copyright information:</b></p><p>Taken from "Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene"</p><p>http://www.biomedcentral.com/1471-2350/8/46</p><p>BMC Medical Genetics 2007;8():46-46.</p><p>Published online 17 Jul 2007</p><p>PMCID:PMC1955437.</p><p></p>lleles A and G respectively. Schematic defining the constructs generated to analyze the function of the two alleles A and G. The PCR generated fragments were cloned into the multiple cloning site at the NheI (N) and BglII (B) restriction sites of the pSEAP2 Basic vector

Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene-1

<p><b>Copyright information:</b></p><p>Taken from "Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene"</p><p>http://www.biomedcentral.com/1471-2350/8/46</p><p>BMC Medical Genetics 2007;8():46-46.</p><p>Published online 17 Jul 2007</p><p>PMCID:PMC1955437.</p><p></p> measured amount of beta galactosidase to obtain the normalized readings. All constructs that contained the Ar allele showed normalized readings similar to the Basic (-) control, which did not possess the SV40 promoter. The opposite result was observed for the constructs that contained the Pr allele. Pr allele constructs showed normalized readings similar to the Control (+), which possessed the SV40 promoter and the alkaline phosphatase reporter gene