The role of dredge-up in double white dwarf mergers

We present the results of an investigation of the dredge-up and mixing during the merger of two white dwarfs with different chemical compositions by conducting hydrodynamic simulations of binary mergers for three representative mass ratios. In all the simulations, the total mass of the two white dwarfs is $\lesssim1.0~{\rm M_\odot}$. Mergers involving a CO and a He white dwarf have been suggested as a possible formation channel for R Coronae Borealis type stars, and we are interested in testing if such mergers lead to conditions and outcomes in agreement with observations. Even if the conditions during the merger and subsequent nucleosynthesis favor the production of $^{18}{\mathrm O}$, the merger must avoid dredging up large amounts of $^{16}{\mathrm O}$, or else it will be difficult to produce sufficient $^{18}{\mathrm O}$ to explain the oxygen ratio observed to be of order unity. We performed a total of 9 simulations using two different grid-based hydrodynamics codes using fixed and adaptive meshes, and one smooth particle hydrodynamics (SPH) code. We find that in most of the simulations, $>10^{-2}~{\rm M_\odot}$ of $^{16}{\mathrm O}$ is indeed dredged up during the merger. However, in SPH simulations where the accretor is a hybrid He/CO white dwarf with a $\sim 0.1~{\rm M_\odot}$ layer of helium on top, we find that no $^{16}{\mathrm O}$ is being dredged up, while in the $q=0.8$ simulation $<10^{-4}~{\rm M_\odot}$ of $^{16}{\mathrm O}$ has been brought up, making a WD binary consisting of a hybrid CO/He WD and a companion He WD an excellent candidate for the progenitor of RCB stars.Comment: Accepted for publication in Ap

Exploring Molecular Simulations of a Plausible Prebiotic Reduced Phospholipid Using Hyperchem Software

How the first cells emerged from the primordial milieu is one of the great questions in science. Biomolecular emergence scenarios abound in the literature, but the lack of bioaccessible phosphate and molecular oxygen on the primordial Earth has posed formidable challenges for deducing emergence pathways. One idea gaining wide acceptance invokes delivery of the phosphide mineral schreibersite ((Fe,Ni)3P) to Earth via meteorite impacts ca. 4.2 billion years ago, whereupon they were corroded to reduced phosphorous oxyacids and phosphonates in primordial aquatic environments. We previously proposed that these reduced phosphorus forms could readily combine with putative geochemical species in shallow mineral-rich alkaline hydrothermal systems to form reduced phospholipid analogs of contemporary phosphate-based phospholipids (Fitch, N.W., K.L. Even, L.J. Leinen and M.O. Gaylor. 2016. Plausible prebiotic assembly of a primitive reduced phospholipid from meteoritic phosphorus on the primordial earth. Proceedings of the South Dakota Academy of. Science 95:176.). Lacking resources to empirically validate this idea, we explored “water box” simulations of the proposed phospholipid structure using the HyperChem software package. Simulation results showed the hydrophobic tails migrating away from water molecules, while hydrophilic heads migrated towards them, resulting in quasistacking behaviors consistent with those of known amphiphiles in water. Inspired by these results, we are now investigating more complex primordial simulation scenarios

Identification of Behavioral and Metabolic Factors Predicting Adiposity Sensitivity to Both High Fat and High Carbohydrate Diets in Rats

Individuals exhibit a great variation in their body weight (BW) gain response to a high fat diet. Identification of predictive factors would enable better directed intervention toward susceptible individuals to treat obesity, and uncover potential mechanisms for treatment targeting. We set out to identify predictive behavioral and metabolic factors in an outbred rat model. 12 rats were analyzed in metabolic cages for a period of 5 days during both high carbohydrate diet (HCD), and transition to a high fat diet (HFD). After a recovery period, rats were given a HFD for 6 days to identify those resistant or sensitive to it according to BW gain. Rats were dissected at the end of the study to analyze body composition. This showed that small differences in final BW hid large variations in adiposity, allowing separation of rats into a second classification (final adiposity). Since these rats had been fed a HCD during most of their life, under which most of the adiposity presumably evolved, we considered this carbohydrate-sensitivity or -resistance. Meal size and meal number were found to be good predictors of sensitivity to a HFD, intensity of motor activity and ingestion speed good predictors of sensitivity to a HCD. Rats that were sensitive to the HCD could be resistant to the HFD and vice versa. This points to four types of individuals (carbohydrate/fat resistant/sensitive) though our sample size inhibited deeper investigation of this. This contributes to the idea that to be “obesity prone” does not necessarily need a HFD, it can also happen under a HCD, and be a hidden adiposity change with stable BW

Low protein/low methionine/high carbohydrate diets induce hyperphagia, increase energy expenditure and FGF21, but modestly affect adiposity infemale BalbC mice.

International audienceTitle: Low protein/low methionine/high carbohydrate diets induce hyperphagia, increase energy expenditure and FGF21, but modestly affect adiposity in female BalbC mice ABSTRACT PREVIEW Author(s)ObjectivesLow-protein diets are reported to induce hyperphagia in an effort to fulfil protein needsbut at the expense of energy balance with a risk to gain in adiposity. However, differentstudies conducted on low-protein diets in animal and human did not confirm weight andbody fat gain because an increased energy expenditure compensated more or lesscompletely for the increase in energy intake and prevents the gain in adiposity. Thepresent study evaluated in mice the consequence of protein restricted diets combined withprotein quality (milk protein versus soy protein with slight methionine deficiency) onenergy intake, energy expenditure and adiposity and the role of FGF21 in the response tothese protein restricted dietsMethodsThe present study investigated in female BalbC mice the behavioral, metabolic andphenotypic responses to 8 weeks feeding a very low (3%), moderately low (6%) or adequate(20%) dietary protein content and whether methionine scarcity in the dietary protein (Soyprotein vs casein) affected these responses. Food intake, body weigh, adiposity (assessedby DEXA), were measured throughout the study and body composition determined bydissection at the end of the study. Plasma, liver, muscle, adipose tissue and hypothalamussamples were collected for nutrient, hormones and/or gene expression measurements.The different mice groups : P20C 20% casein, P20S 20% soy protein, P6C 6% casein, P6S 6%soy protein, P6S-Cor 6% soy protein corrected for methionine, P3C 3% caseinResultsIn female adult BalbC mice, a decrease in dietary casein from 20% to 6% and 3% increasedenergy intake and slightly increased adiposity, and this response was exacerbated with soyproteins with low methionine content compared to milk protein (figure 1). Lean body masswas reduced in 3% casein fed mice but preserved in all 6% fed mice. The effect on fat masswas however limited because total energy expenditure (TEE) increased to the same extentas energy intake (figure 2). In plasma, when protein was decreased, IGF-1 decreased, FGF21increased and plasma FGF21 was best described by using a combination of dietary proteinlevel, protein to carbohydrate ratio and protein to methionine ratio in the diet (figure 3). Insulinresponse to an oral glucose tolerance test was reduced in soy fed mice and in low-proteinfed mice. Low-protein diets did not affect Ucp1 but increased Fgf21 in brown adiposetissue and increased Fgf21, Fas, and Cd36 in the liver. In the hypothalamus, Npy wasincreased and Pomc was decreased only in 3% casein fed mice.Conclusions In conclusion, reducing dietary protein and protein quality increases energy intake but alsoenergy expenditure resulting in an only slight increase in adiposity. In this process FGF21 isprobably an important signal that responds to a complex combination of proteinrestriction, protein quality and carbohydrate content of the diet

Do R Coronae Borealis Stars Form from Double White Dwarf Mergers?

A leading formation scenario for R Coronae Borealis (RCB) stars invokes the merger of degenerate He and CO white dwarfs (WD) in a binary. The observed ratio of 16O/18O for RCB stars is in the range of 0.3-20 much smaller than the solar value of ~500. In this paper, we investigate whether such a low ratio can be obtained in simulations of the merger of a CO and a He white dwarf. We present the results of five 3-dimensional hydrodynamic simulations of the merger of a double white dwarf system where the total mass is 0.9 Mdot and the initial mass ratio (q) varies between 0.5 and 0.99. We identify in simulations with $q\lesssim0.7$ a feature around the merged stars where the temperatures and densities are suitable for forming 18O. However, more 16O is being dredged-up from the C- and O-rich accretor during the merger than the amount of 18O that is produced. Therefore, on a dynamical time scale over which our hydrodynamics simulation runs, a 16O/18O ratio of ~2000 in the "best" case is found. If the conditions found in the hydrodynamic simulations persist for 10^6 seconds the oxygen ratio drops to 16 in one case studied, while in a hundred years it drops to ~4 in another case studied, consistent with the observed values in RCB stars. Therefore, the merger of two white dwarfs remains a strong candidate for the formation of these enigmatic stars.Comment: 42 pages, 19 figures. Accepted for publication in the Astrophysical Journa

A Comparison of Grid-based and SPH Binary Mass-transfer and Merger Simulations

There is currently a great amount of interest in the outcomes and astrophysical implications of mergers of double degenerate binaries. In a commonly adopted approximation, the components of such binaries are represented by polytropes with an index of n = 3/2. We present detailed comparisons of stellar mass-transfer and merger simulations of polytropic binaries that have been carried out using two very different numerical algorithms - a finite-volume grid code and a smoothed-particle hydrodynamics (SPH) code. We find that there is agreement in both the ultimate outcomes of the evolutions and the intermediate stages if the initial conditions for each code are chosen to match as closely as possible. We find that even with closely matching initial setups, the time it takes to reach a concordant evolution differs between the two codes because the initial depth of contact cannot be matched exactly. There is a general tendency for SPH to yield higher mass transfer rates and faster evolution to the final outcome. We also present comparisons of simulations calculated from two different energy equations: in one series, we assume a polytropic equation of state and in the other series an ideal gas equation of state. In the latter series of simulations, an atmosphere forms around the accretor, which can exchange angular momentum and cause a more rapid loss of orbital angular momentum. In the simulations presented here, the effect of the ideal equation of state is to de-stabilize the binary in both SPH and grid simulations, but the effect is more pronounced in the grid code

Clinical outcomes, radiologic kinematics, and effects on sagittal balance of the 6 df LP-ESP lumbar disc prosthesis

Background context: Surgical treatment of degenerative disc disease remains a controversial subject. Lumbar fusion has been associated with a potential risk of segmental junctional disease and sagittal balance misalignment. Motion preservation devices have been developed as an alternative to fusion. The LP-ESP disc is a one-piece deformable device achieving 6 df, including shock absorption and elastic return. This is the first clinical report on its use. Purpose: To assess clinical outcomes and radiologic kinematics in the first 2 years after implantation. Study design: Prospective cohort of patients with LP-ESP total disc replacement (TDR) at the lumbar spine. Patient sample: Forty-six consecutive patients. Outcome measures Clinical outcomes were the visual analog scale (VAS) for pain, the Oswestry disability index (ODI), and the GHQ28 (General Health Questionnaire) psychological score. Radiologic data were the range of motion (ROM), sagittal balance parameters, and mean center of rotation (MCR). Methods: Patients had single-level TDR at L4–L5 or L5–S1. Outcomes were prospectively recorded for 2 years (before and at 3, 6, 12, and 24 months after surgery). The SpineView software was used for computed analysis of the radiographic data. Paired t tests were used for statistical comparisons. Results: No intraoperative complication occurred. All clinical scores improved significantly at 24 months: the back pain VAS scores by a mean of 4.1 points and the ODI by 33 points. The average ROM of the instrumented level was 5.4°±4.8° at 2 years and more than 2° for 76% of prostheses. The MCR was in a physiological area in 73% of cases. The sagittal balance (pelvic tilt, sacral slope, and segmental lordosis) did not change significantly at any point of the follow-up. Conclusions: Results from the 2-year follow-up indicate that LP-ESP prosthesis recreates lumbar spine function similar to that of the healthy disc in terms of ROM, quality of movement, effect on sagittal balance, and absence of modification in the kinematics of the upper adjacent level

Localized helium excitations in 4He_N-benzene clusters

We compute ground and excited state properties of small helium clusters 4He_N containing a single benzene impurity molecule. Ground-state structures and energies are obtained for N=1,2,3,14 from importance-sampled, rigid-body diffusion Monte Carlo (DMC). Excited state energies due to helium vibrational motion near the molecule surface are evaluated using the projection operator, imaginary time spectral evolution (POITSE) method. We find excitation energies of up to ~23 K above the ground state. These states all possess vibrational character of helium atoms in a highly anisotropic potential due to the aromatic molecule, and can be categorized in terms of localized and collective vibrational modes. These results appear to provide precursors for a transition from localized to collective helium excitations at molecular nanosubstrates of increasing size. We discuss the implications of these results for analysis of anomalous spectral features in recent spectroscopic studies of large aromatic molecules in helium clusters.Comment: 15 pages, 5 figures, submitted to Phys. Rev.