FAKTOR-FAKTOR YANG MEMPENGARUHI EFEKTIVITAS GABUNGAN KELOMPOK TANI (GAPOKTAN) DALAM PROGRAM PENGEMBANGAN USAHA AGRIBISNIS PERDESAAN (PUAP) DI KECAMATAN PEDAN KABUPATEN KLATEN

n this paper we give the full classification of curves $C$ of genus $g$ such that a Brill--Noether locus $W^ s_d(C)$, strictly contained in the jacobian $J(C)$ of $C$, contains a variety $Z$ stable under translations by the elements of a positive dimensional abelian subvariety $A\subsetneq J(C)$ and such that $\dim(Z)=d-\dim(A)-2s$, i.e., the maximum possible dimension for such a $Z$

Treatment of tumours with the combination of WR-2721 and cis-dichlorodiammineplatinum (II) or cyclophosphamide.

The ability of WR-2721 [S-2(3-aminopropylamino)ethyl-phosporothioic acid] to selectively protect the host against the toxic effects of multiple doses of cis-dichlorodiammineplatinum [cis-Pt] or cyclophosphamide [CY] has been studied in mice and rats bearing 3 different tumours. Selective protection against cis-Pt induced nephrotoxicity has been demonstrated under all conditions studied, with the extent of protection being inversely related to the size of the cis-Pt dose. For example, pre-treatment with 200 mg/kg of WR-2721 30 min before each weekly dose of 2 mg/kg of cis-Pt allows the administration of this cytotoxic agent for 3 times longer before nephrotoxic injury. In none of these studies was there tumour protection. The same pattern was observed with CY, but quantitation of the extent of marrow protection was not possible for the multiple treatment studies, due to the longer latent period between induced and observed death with this drug. We conclude, therefore, that for both of these drugs, selective protection of the kidney and marrow is not only maintained under conditions of multiple treatment, but actually enhanced due to the need for smaller doses of cytotoxic agents in these protocols

Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury

The past few years have seen an increase in the clinical awareness of post-traumatic stress disorder (PTSD), one of the most disabling and least understood behavioral disorders. Although the biological bases of PTSD are poorly understood, fatty-acid amide hydrolase (FAAH) activity has been linked with arousability and aversive-memories extinction, that is, two key features of PTSD. In this study, we investigated the association between the FAAH genetic polymorphisms and PTSD development and maintenance. We assessed PTSD frequency in a group of male Vietnam war veterans who suffered combat-related penetrating traumatic brain injury, that is, a relatively homogeneous population regarding the nature of the events that led to PTSD. We showed that rs2295633, a single-nucleotide polymorphism of FAAH, was significantly associated with PTSD diagnosis in subjects without lesions in the ventromedial prefrontal cortex. Moreover, the presence of the C allele was associated with more severe re-experiencing of trauma and more negative reported childhood experiences. In conclusion, our data suggest that FAAH has an important role in PTSD through modulation of aversive memories and point to both a novel therapeutic target and a possible risk marker for this condition

The orbifold cohomology of moduli of genus 3 curves

In this work we study the additive orbifold cohomology of the moduli stack of smooth genus g curves. We show that this problem reduces to investigating the rational cohomology of moduli spaces of cyclic covers of curves where the genus of the covering curve is g. Then we work out the case of genus g=3. Furthermore, we determine the part of the orbifold cohomology of the Deligne-Mumford compactification of the moduli space of genus 3 curves that comes from the Zariski closure of the inertia stack of M_3.Comment: 29 pages, 2 figures. Minor changes, to appear in Manuscripta Mat

Total Synthesis of Asparenydiol by Two Sonogashira Cross-Coupling Reactions Promoted by Supported Pd and Cu Catalysts

Asparenydiol, which is an important natural compound with potential pharmacological activities, was synthesized through two Sonogashira cross-coupling reactions catalyzed by supported Pd and Cu catalysts and by a Mitsunobu etherification. The optimization of the Sonogashira couplings allowed the use of catalysts supported on different matrices with good results in terms of catalytic efficiency and yields

On the canonical map of surfaces with q>=6

We carry out an analysis of the canonical system of a minimal complex surface of general type with irregularity q>0. Using this analysis we are able to sharpen in the case q>0 the well known Castelnuovo inequality K^2>=3p_g+q-7. Then we turn to the study of surfaces with p_g=2q-3 and no fibration onto a curve of genus >1. We prove that for q>=6 the canonical map is birational. Combining this result with the analysis of the canonical system, we also prove the inequality: K^2>=7\chi+2. This improves an earlier result of the first and second author [M.Mendes Lopes and R.Pardini, On surfaces with p_g=2q-3, Adv. in Geom. 10 (3) (2010), 549-555].Comment: Dedicated to Fabrizio Catanese on the occasion of his 60th birthday. To appear in the special issue of Science of China Ser.A: Mathematics dedicated to him. V2:some typos have been correcte

Composite MRI measures and short-term disability in patients with clinically isolated syndrome suggestive of MS

The use of composite magnetic resonance imaging (MRI) measures has been suggested to better explain disability in patients with multiple sclerosis (MS). However, little is known about the utility of composite scores at the earliest stages of the disease