Исследование эффективности лекарственного средства «Валикар» у спортсменов-единоборцев в период интенсивных тренировочных нагрузок. Сообщение 1. Динамика общей физической работоспособности

The first report of a series of articles on the results of clinical testing of the anti-asthenic drug “Valikar” of 31 martial arts athletes in conditions of the intensive training loads presents the results of a study of the dynamics of general physical performance. The results demonstrated the greater efficiency of the work performed on the part of energy exchange and the cardiovascular system in aerobic modes of operation for athletes who received «Valikar» (main observation group) compared with the placebo group. The fifteen-day intake of «Valikar» by martial athletes increased the threshold of anaerobic exchange of the study compared to the initial state.В первом сообщении цикла статей по результатам клинической апробации противоастенического лекарственного средства “Валикар” у 31 спортсмена-единоборца в условиях интенсивных тренировочных нагрузок представлены результаты исследования динамики общей физической работоспособности. Полученные результаты продемонстрировали большую экономичность выполняемой работы со стороны энергообмена и сердечно-сосудистой системы в аэробных режимах работы у спортсменов, получавших ЛС «Валикар» (основная группа наблюдения) по сравнению с группой плацебо. Пятнадцатидневный прием ЛС «Валикар» спортсменами-единоборцами способствовал повышению порога анаэробного обмена исследования по сравнению с исходным состоянием

Efficiency of the «Valikar» drug on the example of one-offer athletes-wrestlers during the intensive training loads. Communication 1. Dynamics of general physical performance

The first report of a series of articles on the results of clinical testing of the anti-asthenic drug “Valikar” of 31 martial arts athletes in conditions of the intensive training loads presents the results of a study of the dynamics of general physical performance. The results demonstrated the greater efficiency of the work performed on the part of energy exchange and the cardiovascular system in aerobic modes of operation for athletes who received «Valikar» (main observation group) compared with the placebo group. The fifteen-day intake of «Valikar» by martial athletes increased the threshold of anaerobic exchange of the study compared to the initial state.В первом сообщении цикла статей по результатам клинической апробации противоастенического лекарственного средства “Валикар” у 31 спортсмена-единоборца в условиях интенсивных тренировочных нагрузок представлены результаты исследования динамики общей физической работоспособности. Полученные результаты продемонстрировали большую экономичность выполняемой работы со стороны энергообмена и сердечно-сосудистой системы в аэробных режимах работы у спортсменов, получавших ЛС «Валикар» (основная группа наблюдения) по сравнению с группой плацебо. Пятнадцатидневный прием ЛС «Валикар» спортсменами-единоборцами способствовал повышению порога анаэробного обмена исследования по сравнению с исходным состоянием

Interaction of Charged Hydroxyapatite and Living Cells. I. Hydroxyapatite Polarization Properties

The most principal methods of studying hydroxyapatite (HAP) nanostructures and proton transfer peculiarities, its polarization properties are presented in this paper. HAP is one of the most widely used materials in medicine and biotechnology. The interaction between HAP biomaterials and living cells is improved, if the HAP surface is charged. The charge is inducible on HAP ceramics by the proton transport along the OH chains in columnar channels. These chains are formed by OH ions along c-axis and are surrounded by calcium triangles. The paper presents ab initio quantum-chemical calculations (with Gaussian98 code, HF, 6-31G(d)), which clarify the double-well asymmetric potential energy profile and were held to investigate the energy barriers for proton transport along the columnar channel. The calculated values of barriers can explain long storage of polarization charge, which is observed in experiments. The value of applied electric field could switch asymmetry of double-wall potential and made the proton transfer possible is of the order of 109 V/m, but proton tunneling is possible at 106 V/m. The estimated value of HAP surface polarization ~ 0.1 C/m2 influences movement of living cells and leads to their adhesion on the charged HAP surface

Size Depended Electrical Properties of Hydroxyapatite Nanoparticles

Hydroxyapatite (HAp) nanoparticles is widely in use to fabricate implants. Computer simulation was employed to understand the HAp clusters structural and electrical (dipole momentum and polarization - surface charges) properties. A size (X) of the simulated cluster has an influence on its dipole momentum, polarization and as the result on the electron work function (ϕ). Saturation of hydrogen bonds and the size of the cluster have an influence on its surface polarization. Values of ϕ were experimentally estimated owing to photoelectron emission measurements. The magnitude of ϕ was demonstrated positive correlation on X. The nanoparticles demonstrated a capability to be gathered within conglomerates. This property is confirmed by calculated surface disordering of HAp nanoparticles leading to its higher interaction

A Computational Study of the Properties and Surface Interactions of Hydroxyapatite

Hydroxyapatite (HAP, Ca10(PO4)6(OH)2) was studied from first principles approaches using the local density approximation (LDA) method in combination with various quantum-chemical (QM) and molecular mechanical (MM) methods from HypemChem 7.5/8.0. The data then were used for studies of HAP structures, and the interactions of HAP clusters with ionic species such as citrates. Computed data show that HAP can co-exist in different phases at room temperature, as both hexagonal and monoclinic. Special interest is connected with the ordered monoclinic structure, which could reveal piezoelectric properties. Obtained data on HAP interactions with citrates show the formation of differing HAP nanostructure forms, depending upon the concentration of citrate present