Drawings from Syria\u27s Lost Generation: Psychological Impacts of the Refugee Crisis

Since the onset of the Syrian civil war in 2011, more than 11 million people have been forcibly displaced and exposed to violence. Even if the civil war were to end tomorrow, the refugee crisis will be expected to last for decades more. With nearly half of the refugees being children, the impact of the loss of health, education, social networks, and home environments on children have resulted in what is being called Syria‟s lost generation. A potential solution in mitigating these psychological impacts is the reintegration from refugee camps into non-camp host communities or the resettlement into other countries. Through the psychological analysis of children‟s drawings, this research project hopes to study the mitigating impact of reintegration on the likelihood of anxiety, depression, and posttraumatic stress disorder on Syrian refugee children

Finding relationships between effort and other variables in the SEL

Estimating the amount of effort required for a software development project is one of the major aspects of resource estimation for that project. In this study, the relationship between effort and other variables for 23 Software Engineering Laboratory (SEL) projects that were developed for NASA/Goddard Space Flight Center was examined. These variables fell into two categories: those which can be determined in the early stages of project development and may therefore be useful in a baseline equation for predicting effort in future projects, and those which can be used mainly to characterize or evaluate effort requirements and thus enhance the understanding of the software development process in this environment. Some results of the analyses are presented

Lessons learned in deploying software estimation technology and tools

Developing a software product involves estimating various project parameters. This is typically done in the planning stages of the project when there is much uncertainty and very little information. Coming up with accurate estimates of effort, cost, schedule, and reliability is a critical problem faced by all software project managers. The use of estimation models and commercially available tools in conjunction with the best bottom-up estimates of software-development experts enhances the ability of a product development group to derive reasonable estimates of important project parameters. This paper describes the experience of the IBM Software Solutions (SWS) Toronto Laboratory in selecting software estimation models and tools and deploying their use to the laboratory's product development groups. It introduces the SLIM and COSTAR products, the software estimation tools selected for deployment to the product areas, and discusses the rationale for their selection. The paper also describes the mechanisms used for technology injection and tool deployment, and concludes with a discussion of important lessons learned in the technology and tool insertion process

Numerical Modelling of Flood Forces due to Storm Surges

早稲田大学博士(工学)早大学位記番号:新9353doctoral thesi

Developmental neurotoxicity of the harmful algal bloom toxin domoic acid: Cellular and molecular mechanisms underlying altered behavior in the zebrafish model

This paper is not subject to U.S. copyright. The definitive version was published in Environmental Health Perspectives 128(11), (2020): 117002, doi:10.1289/EHP6652.Background: Harmful algal blooms (HABs) produce potent neurotoxins that threaten human health, but current regulations may not be protective of sensitive populations. Early life exposure to low levels of the HAB toxin domoic acid (DomA) produces long-lasting behavioral deficits in rodent and primate models; however, the mechanisms involved are unknown. The zebrafish is a powerful in vivo vertebrate model system for exploring cellular processes during development and thus may help to elucidate mechanisms of DomA developmental neurotoxicity. Objectives: We used the zebrafish model to investigate how low doses of DomA affect the developing nervous system, including windows of susceptibility to DomA exposure, structural and molecular changes in the nervous system, and the link to behavioral alterations. Methods: To identify potential windows of susceptibility, DomA (0.09–0.18 ng) was delivered to zebrafish through caudal vein microinjection during distinct periods in early neurodevelopment. Following exposure, structural and molecular targets were identified using live imaging of transgenic fish and RNA sequencing. To assess the functional consequences of exposures, we quantified startle behavior in response to acoustic/vibrational stimuli. Results: Larvae exposed to DomA at 2 d postfertilization (dpf), but not at 1 or 4 dpf, showed consistent deficits in startle behavior at 7 dpf, including lower responsiveness and altered kinematics. Similarly, myelination in the spinal cord was disorganized after exposure at 2 dpf but not 1 or 4 dpf. Time-lapse imaging revealed disruption of the initial stages of myelination. DomA exposure at 2 dpf down-regulated genes required for maintaining myelin structure and the axonal cytoskeleton. Discussion: These results in zebrafish reveal a developmental window of susceptibility to DomA-induced behavioral deficits and identify altered gene expression and disrupted myelin structure as possible mechanisms. The results establish a zebrafish model for investigating the mechanisms of developmental DomA toxicity, including effects with potential relevance to exposed sensitive human populations. https://doi.org/10.1289/EHP6652This research was supported by the Oceans Venture Fund, the Von Damm Fellowship, the Ocean Ridge Initiative Fellowship, and Woods Hole Sea grant (NA14OAR4170074) (all to J.M.P.), and by the Woods Hole Center for Oceans and Human Health (NIH: P01ES021923 and P01ES028938; NSF: OCE-1314642 and OCE-1840381; Center PI: John Stegeman, Project PI: M.E.H.)