6 research outputs found
Participación de la mujer en el proceso de la independencia: Un estudio con perspectiva de género /
- Publication venue
- Universidad Autónoma del Caribe.
- Publication date
- 18/05/2016
- Field of study
Estado INACTIVO
Semillero UNIAUTONOMA
Área del Proyecto Ciencias Sociales Subárea del Proyecto Derecho
Tipo de Proyecto Proyecto de Investigación Subtipo de Proyecto Propuesta de Investigación
Grado VII Semestr Programa Académico DERECHOHistóricamente ha prevalecido un sistema que busca justificar las relaciones de denominación-subordinación entre los sexos; un sistema que ha pretendido la ubicación casi exclusiva de la mujer en el ámbito de lo domestico, percibido como más natural y ajustado al ejercicio del rol social tradicionalmente asignado a ella. Sistema que ha pretendido igualmente desconocer a la mujer históricamente en los aportando que ésta ha hecho en los momentos decisivos de la vida del país. La invisibilización o desconocimiento del aporte de la mujer en los procesos de desarrollo del país y particularmente en el proceso de liberación del yugo español se debe al hecho de que la historia oficial ha estado marcada por una fuerte estructura androcéntrica, escrita principalmente por hombres que han exaltado la actuación de los “héroes” desconociendo o invisibilizando la muy valiosa participación de nuestras heroínas, que no son únicamente las que figuran de manera forzosa en los manuales escolares de historia
Caminando en la ruta sentipensante: configuración de experiencias pedagógicas nivel inicial
- Author
- Aguja Ana Irma
- Alvarado Contreras Katherine
- Ariza Erick
- Arévalo Castillo Nidya Teresa
- Baquero Farfán Diana Milena
- Becerra Marcela Díaz
- Bermúdez Milena
- Bolaños Edwin Alberto
- Borja Carlos
- Camelo Rodríguez Lindsay Johana
- Campos de la Roche Andrea
- Canaval Luz Andrea
- Chindoy Jamioy Aura Milena
- Cruz Rivas Luz Clara
- Cuineme Mónica Yasmín
- Cárdenas Jenny
- Delgado Amparo
- Delgado Zulma Giovanna
- Durán Suárez Magda Esperanza
- Díaz López Karina
- Escorcia Romero Tadiana Guadalupe
- Esguerra Díaz Diana Carolina
- Espinosa Porras Sonia Carmenza
- Fajardo Muñoz Luz Myriam
- Fajardo Luz Yenny
- Fernández Ángela
- Garzón Ramírez John Fredy
- González Alexandra
- Guataquira López Rossmajer
- Gómez Hernández Rosalba
- Gómez Nancy
- Hernández Leguizamón Carolina
- Iguarán Olaya Nubia Elizabeth
- Martínez Karen Andrea
- Martínez Nidia Cristina
- Montealegre David Santiago
- Montealegre Diana
- Montoya Velasco Diana Carolina
- Mora Luz Marina
- Moreno Ana Rosa
- Mosquera Bravo Nancy Patricia
- Munar Díaz Jairo Enrique
- Muñoz de la Rosa Inés del Rosario
- Méndez Gómez Diana Marcela
- Negrete Edith Constanza
- Olmos Daniel
- Ortega Ana Paola
- Pacheco Carlos Martínez
- Parada González Leidy Mayerly
- Parra Elsa Patricia
- Pava Hermann
- Peña Sopo Brhiter
- Prieto Beltrán Naydú
- Quevedo Mejía Cecilia
- Ramos Suárez René
- Ramírez Cabanzo María Helena
- Ramírez Sánchez Leidy Alejandra
- Ramírez-Cabanzo Ana Brizet
- Rico Rodríguez Angélica
- Rincón Lovera Maribel
- Rojas Diego Alexis
- Romero Lozano Stefanie
- Ruiz Ramírez Jonathan Eduardo
- Ruiz Karen Johanna
- Ríos Rodríguez Gabriel Jaime
- Sotelo Guerrero Haydee
- Sánchez Reyes Leslie Alexa
- Triana Mossos Mónica
- Vargas José Joaquín
- Vargas Leidy
- Publication venue
- Publication date
- 01/01/2021
- Field of study
494 páginasEste texto es realizado en el contexto del Plan de Desarrollo 2016 – 2020, “Bogotá mejor para todos”, en el que se señala: Bogotá es entendida como una ciudad educadora, en la que todos los ciudadanos son agentes educadores y todos los espacios pueden ser escenarios pedagógicos para el aprendizaje. Una ciudad educadora tiene como centro el conocimiento e inspira aprendizaje, formas y lenguajes para reconocernos, para reencontrarnos; los espacios para el aprendizaje son entendidos como espacios para la vida, en los que se posibilita la investigación y la innovación para vivir mejor, para reinventarnos como ciudad, una ciudad mejor para todos.
Los dieciocho textos aquí presentados, fruto del acompañamiento pedagógico realizado por el IDEP en 2019, son base y referente para seguir aportando en la configuración y consolidación de comunidades de saber y práctica pedagógica de la ciudad, así como en la conformación de colectivos y redes de maestros. Son la evidencia de un potente trabajo de acompañamiento a experiencias de nivel inicial, caracterizadas por contar con ideas o avances para problematizar, estructurar, fundamentar, elaborar estrategias y un plan de acción
Evolution over Time of Ventilatory Management and Outcome of Patients with Neurologic Disease∗
- Author
- Abderrahim Azzouzi
- Abroug F.
- Achille Kouatchet
- Achim Lunkeit
- Adam Mikstacki
- Aguilera García
- Ahmed Sbihi
- Ai-Chin Cheng
- Ainhoa Rosselló
- Alain Mercat
- Alan Javier Zazu
- Alberto Belenguer
- Alberto Deicas
- Alberto Marino
- Alberto Soler
- Alejandro Algora
- Alejandro Arroliga
- Alejandro de la Serna
- Alejandro Gómez
- Alejandro Raimondi
- Alejandro Risso
- Alfonso Moreno
- Alfonso Muñoz
- Alfredo Padrón
- Alfredo Vasquez-Sandoval
- Ali Aydım Altunkan
- Ali Zeggwagh A.
- Aline Camile Yehia
- Alistair Nichol
- Allan Walkey
- Allison Bone
- Aloísio Marques do Nascimento
- Alvaro van Bommel
- Amalia Martínez de la Gandara
- Amber Monson
- Ambrogio Sansone
- Amee Patrawalla
- Amin P.
- Amine Ali Zeggwagh
- Amparo Ferrandiz
- Amy Waters
- Ana Carolina Caballero
- Ana Esther Trujillo
- Ana Villagrá
- Anders Aneman
- Andrea Gimenez
- Andrea Matte
- Andrea Neville Cracchiolo
- Andreas Schwartz
- Andreas Viehöfer
- Andrei Piontek
- Andrew Bersten
- Andrew Davies
- Andrew Davies
- Andrew Davies
- Andrew Steel
- Andrey Yaroshetskiy
- Anette Mortensen
- Anitha Shenoy
- Ankur Devendra Bhavsar
- Annunziata Mattei
- Anthony Saleh
- Antonina Pigna
- Antonino Giarratano
- Antonio Anzueto
- Antonio Braschi
- Antonio Corcione
- Antonio García-Jiménez
- Antonio Maestre
- Antonio Pesenti
- Antonio Raso
- Antonio Reyes
- Antonio Villa Delgado
- Antonio Viñuales
- Anzueto A.
- Arianna Boggero
- Ariel Chena
- Armando Pedulla'
- Arnaud W Thille
- Ashley Ellis
- Ashley Ellis
- Asisclo J Villagómez Ortiz
- Auke Reidinga
- Ayed Samia
- Barbara Tamowicz
- Barrios D.
- Bas M Kors
- Begoña Balerdi
- Benoit Veber
- Bernabé Álvarez
- Bersten A.
- Bert Beishuizen
- Besbes Mohamed
- Bilge Çetin
- Bin Du
- Bin Du
- Bin Yu
- Bing Sun
- Birgitte Viebaek
- Bladimir Alejandro Gil
- Bo Broberg
- Bo Wang
- Boris Villamagua
- Brian Sherman
- Bruno Bonaccorsi Fernandino
- Bruno do Valle Pinheiro
- Bryan Beatty
- C Canevet
- Cakar N.
- Cameron Knott
- Camilo Pizarro
- Carlo Alberto Acosta
- Carlos Alberto Studart Gomes
- Carlos André Correia Casado
- Carlos Andrés Díaz
- Carlos Gallego
- Carlos Marian Crespo
- Carlos Robles-Arias
- Carmelo Dueñas
- Carmen Campos
- Carolina Gímenez-Esparza
- Carolina Lorencio
- Cartan Costello
- Catherine Simmonds
- Cayce Strength
- Cayetano Galetti
- Cecilia Carbayo
- Cecilia Hermosa
- Cecilia Pereyra
- Cesar Enciso
- Cezar Mihailescu
- Chabu Coronado
- Chafrina Marie Olay
- Chang Liu
- Chantal Hogan
- Charki Haimeur
- Chau Chin Man
- Chen Chin-Ming
- Chengmin Yu
- Cheromi Sittambalam
- Cheryl Cuzner
- Cheryl Ethier
- Chiara Verga
- Christian Frenkel
- Christian Putensen
- Christopher MacIsaac
- Christopher Spradley
- Chuanyun Qian
- Claire Cattigan
- Claire Reynolds
- Clara Laplaza Eva Regidor
- Clara Pacheco
- Claudia Diaz
- Claudia Olvera-Guzman
- Craig A Piquette
- Craig Cernosek
- Crissie De Spirito
- Crissie Despirito
- Cristian Casabella
- Cristian Cevallos
- Cristina Orlandi
- Cristina Santos
- César Antonio Maquilon
- César Aragón
- César Cruz Lozano
- César Pérez-Calvo
- Damian Violi
- Dana K Soetaert
- Daniel Duarte
- Daniel Fontaneda
- Daniel Vargas
- Daniel Weiss
- David Freire
- David Milliss
- Davide Chiumello
- Daxing Yu
- Debiao Song
- Deborah Barge
- Deborah Cook
- Deepak Govil
- Del-Sorbo L.
- Denice Wells
- Dennis Bergmans
- Dhruva Chaudhry
- Di Russo
- Diane Mackle
- Dianne Hill
- Dianne Stephens
- Dietrich Henzler
- Dimitros Matamis
- Dimple Tejwani
- Dinalva Aparecida Gomes
- Do Danh Quynh
- Dolores Vila
- Dongpo Jiang
- Dorothée Carpentier
- Du B.
- Edgard Luna
- Edgardo E Tabhan
- Edgardo Nuñez
- Edoardo De Robertis
- Eduard Bootsma
- Eduardo Almeida
- Eduardo Fonseca Sad
- Edward Nicolayenko
- Eileen Gilder
- Elena Gallego
- Elena Parreño
- Eleni Antoniadou
- Elias Caragna
- Elisa Estenssoro
- Elisha Fulton
- Elisha Matheson
- Ellen Kinkel
- Emily Stern
- Enrique Maraví
- Enrique Piacentini
- Erika Mannelli
- Erin Braden
- Erna Alberts
- Erwin J Oei
- Esteban A
- Eugenio Palazón
- Eva Benveniste
- Eva Manteiga
- Fabien Grelon
- Fabien Soulis
- Fabricio Picoita
- Fachun Zhou
- Falk Hildebrandt
- Fang Xu
- Farhad N Kapadia
- Fausto Fialho Moura
- Federica Antonicelli
- Federica Tallarini
- Federico Gordo
- Fekri Abroug
- Feng Li
- Fernando Antônio Botoni
- Fernando Fernández
- Fernando Lambert
- Fernando Lipovestky
- Fernando Pérez
- Fernando Ríos
- Fernando Saldarini
- Fernando Sánchez
- Fernando Villarejo
- Fernando Villarejo
- Filomena Faria
- Forbes McGain
- Francesca Frigieri
- Francesco Idone
- Francesco Mojoli
- Francisco Criado
- Francisco Guerrero
- Francisco Lucena
- Francisco Manzano
- Francisco Molina
- Francisco Ortuño
- Frank Torres
- Franklin Villegas
- François Collet
- Freddy Sandy
- Freddy Sánchez
- Frederico Costa Val Barros
- Frederico Rodrigues Anselmo
- Frutos-Vivar F.
- Frédéric Bellec
- Félix Lacoma
- Gabriel D Empaire
- Gaetano Perchiazzi
- Gang Li
- Gary Kinasewitz
- Gary Kinasewitz
- Gastón Pittini
- Gaëtan Bedunaeu
- Gee Young Suh
- Gemma Rialp
- Geneva Tatem
- Geng Zhang
- Genis Carrasco
- George Liziamma
- George Lukas
- Gerardo Filippa
- Gilda Diaz-Fuentes
- Gina Quinde
- Giorgia Citterio
- Giorgio Tulli
- Gonzalez M.
- Gonzalo Javier Ríos
- Graciela Elizabeth
- Graciela Franca
- Graeme Duke
- Gregory A Schmidt
- Guillaume Marcotte
- Guillermo Chiappero
- Guillermo Cueto Robledo
- Guillermo Falconí
- Guillermo Muñiz
- Guillermo Ortiz
- Gustavo Badariotti
- Gustavo Jannello
- Gustavo Morales Muñoz
- Gustavo Paredes
- Géraldine Dessertaine
- Haibo Qiu
- Hannah Mathers
- Hans-Henrik Bülow
- Harald Fritz
- Harry P P M Gelissen
- Heinrich Paulus
- Heinz Kerger
- Helen Rodgers
- Helen Wong
- Heloisa Castro
- Henry Caballero
- Hergen Buscher
- Hernan Nunia
- Hernán Nuñez
- Hong Pu
- Hongyang Xu
- Hongyuan Lin
- Howard Connor
- Hugo Capponcelli
- Hugo Urbano
- Hye Sook Choi
- Ian Carrasco
- Ian Moore
- Ian Seppelt
- Ilaria Curro'
- Ilaria Maria Mastromauro
- Imed Chouchene
- Imogen Mitchell
- Ingrid van den Hul
- Ingrid Von der Osten
- Inmaculada Vallverdú
- Irene Aragão
- Irene Dot
- Irene Watpool
- Islem Ouanes
- Ismail Kati
- Itziar Mintegui
- Ivano Aprile
- Jacinto Baena
- Jackeline Coello
- Jan Dittmann
- Jan Friedrich
- Jan Mehrtens
- Jane Thomas
- Janine Dias Alves
- Jasmin Board
- Jasmin Board
- Jasmin Board
- Jason Fletcher
- Javier Blanco
- Javier Castañeda
- Javier Cebrián
- Javier Díaz Domínguez
- Javier García-Alonso
- Javier González-Robledo
- Javier Horacio Álvarez
- Javier Hurtado
- Javier Ladape Martinez
- Javier Ruiz
- Je Hyeong Kim
- Jean-Christophe M Richard
- Jeff Presneill
- Jeffrey Singh
- Jennifer Germain
- Jennifer Goodson
- Jennifer Holmes
- Jennifer Twombley
- Jenny Dennett
- Jens Brushoj
- Jens Buettner
- Jesús Sánchez
- Jesús Sánchez-Ruiz
- Jian Huang
- Jianbiao Meng
- Jianguo Li
- Jianhong Fu
- Jianying Guo
- Jiaqiong Li
- Jibaja M.
- Jin Hwa Lee
- Jin Young An
- Jinghua Wang
- Jiuzhi Zhang
- Joachim Hartung
- Joan Maria Raurich
- Joana Silvestre
- Joanne Sutton
- Jodi Brown
- Johannes Busch
- John Durning
- John Myburgh
- John Oropell
- John Santamaria
- Jorge Arroyo
- Jorge Gerez
- Jorge Vidal Hernández
- Jorgelina Guyon
- Jose Angel Baltazar Torres
- Josep Maria Sirvent
- José Carlos Versiani
- José Claudio Leo
- José Elizalde
- José Francisco López Baca
- José J Blanco
- José Luis Scapellato
- José Manuel Serrano
- José María Gutiérrez
- José María Montón
- José María Nicolás
- José María Quiroga
- José Miguel Guerrero
- José Salinas
- José Salvador Martínez Cano
- Joyce Okahashi
- Juan Carlos
- Juan Carlos Maurelia
- Juan David Uribe
- Juan Diego Jiménez
- Juan Domingo Fernández
- Juan Guerra
- Juan Pablo Sedano
- Juan Ramón Cortés
- Juanxian Gu
- Judi Tai
- Judith Sagardía
- Julia López-Díaz
- Julian Strati
- Julie Smith
- Julio Osorio
- Julio Pontet
- Julián Hernández
- Jun Jin
- Jörg Haberkorn
- Jörn Schlechtweg
- Karina Bonasegla
- Katherine Davidson
- Kathleen Lilli
- Katty Trelles
- Kelly Choy
- Kerry Canady
- Ki-Suck Jung
- Kim Heus
- Konstantinos Raymondos
- Kwan Ming Chit
- Kyung Chan Kim
- Larry Welder
- Laura Jones
- Laura Sayagues
- Laura Wilson
- Laura Álvarez-Montero
- Lauralyn McIntryre
- Laurent Brochard
- Leanne Boehm
- Lei Chen
- Leila Eckholt
- Leonardo Pazmiño
- Leonie Weisbrodt
- Leticia Rapetti
- Liang Pan
- Lidón Mateu
- Liliana Caipe
- Lisa Julien
- Lisandro Betttini
- Loredana Pitagora
- Lori-Ann Kozikowski
- Lucas Vallejo
- Lucia Capilla
- Luis Fernando Castro Castro
- Luis Gonzalez Mosquera
- Luis González Zambrano
- Luis Marina
- Luis Pablo Cardonnet
- Luis Soto-Germani
- Luis Soto-Román
- Luis Williams
- Lutz Pfeiffer
- Lynette Newby
- M Eugenia
- Madhav Gudi
- Madison Dennis
- Maggiore S. M.
- Manoj K Saxena
- Manuel Jibaja
- Manuel Valledor
- Maoqin Li
- Mar Gobernado
- Marc Fabra
- Marc Lipkus
- Marcela Canola-Mazo
- Marcela Granados
- Marcelo Alcântara Holanda
- Marcelo Choque
- Marcelo Ochoa
- Marcelo Palavecino
- Marco Adversi
- Marco Antônio Ribeiro Leão
- Marco Antônio Soares Reis
- Marco Bezzi
- Marco Escobar
- Marco Gonzalez
- Marco González
- Marco Montes De Oca
- Marcos Delgado
- Marcos Juan Zec
- Marcus Ruecker
- Maria Aparecida Braga
- Maria Del Mar Torres-Perez
- Maria Giannakou
- Maria Wussow
- Mariana Monllau
- Marianna Esposito
- Marin M. D. C.
- Marina Busico
- Mario Acosta
- Mario Alonso Treviño Salinas
- Mario Cancela
- Mario Gómez
- Mario Villabon
- Marisol Rodríguez-Goñi
- Mark Bailey
- Mark Tidswell
- Markus Schappacher
- Marta Beron
- Marta Ferrari
- Marta Ugalde
- Martin Deheza
- Martín Lugaro
- Mary La Pine
- María Belén Yapur
- María Del Carmen de la Torre
- María Elena Pérez-Losada
- María Eugenia González
- María Fernanda García
- María Garitacelaya
- María Isabel Ruiz
- María José Tolón
- María Luisa Navarrete
- María Victoria de la Torre
- María Ángeles Alonso
- María Ángeles Pena
- Matamis D.
- Matthew Kirchner
- Matty Koopmans
- Matías Brizuela
- Mauricio Vinzio
- Maurizio Bottiroli
- Maurizio Raineri Santi
- Maurício Meireles Góes
- Maximillian Ragaller
- Mayur Patel
- Medhat Soliman
- Mehar-Un-Nisa Raja
- Mian Chen
- Michael A Kuiper
- Michael Miletin
- Michael Quintel
- Michela Bombino
- Michele Iannuzzi
- Miguel Fernández-Vivas
- Miguel Lazcano
- Miguel León
- Miguel Llano
- Miguel Ángel González-Gallego
- Mijail Játiva
- Mikhail Kirov
- Mikkel Præst
- Minka Springham
- Miquel Ferrer
- Mirko Belliato
- Mohamed A Saad
- Mohammed Al-Jagbeer
- Monica Rocco
- Monika Holler
- Moo Suk Park
- Mounir Bouaziz
- Mourad Amor
- Muriel A.
- Myriam Montalvo
- Myung-Goo Lee
- Nagarajan Ramakrishnan
- Nahit Cakar
- Neill Adhikari
- Nelson Barros
- Nelson Fonseca
- Nelson Medina
- Nghuyen Ba Tuan
- Nguyen Huu Hoang
- Niall Ferguson
- Nicolas Nin
- Nicole Marinoff
- Nicolás Zamboschi
- Nieves Franco
- Nils Marquardt
- Nin N.
- Norberto Tiribelli
- Norberto Tiribelli
- Norma Beatriz Márquez
- Nuria Alonso
- Oliver Franke
- Olivia Dulfo
- Orla Smith
- Oscar Cluzet
- P Kruska
- P Samaddar
- Pablo Desmery
- Pablo Gómez
- Pang Wing Yan
- Paolo Navalesi
- Pascal Beuret
- Pascual Valdez
- Patricia Albert
- Patricia Jimeno
- Patricia Leung
- Patricia Vogl
- Paul Goldrick
- Paul J Dennesen
- Paul Young
- Paulo Marcal
- Pedro Alzugaray
- Pedro Galdos
- Pedro Jesús Domínguez
- Pedro Rosa
- Pelosi P.
- Penuelas O.
- Pertsas Evangelos
- Peter van der Voort
- Pham Thi Van Anh
- Phil Alkana
- Philippe Berger
- Pierre-Gildas Guitard
- Prachee Sathe
- Pravin Amin
- Priya Nair
- Qing Song
- Qingyuan Zhan
- Qunmei Yao
- Rachael Parke
- Rachel Whyte
- Rafael Blancas
- Rafael Morales
- Rahul Nanchal
- Raju Pusapati
- Ramiro Puetate
- Raquel Manzanedo
- Raquel Montoiro
- Raquel Yano
- Raymondos K.
- Raúl de Pablo
- Raúl González
- Raúl Lombardi
- Remzi Iscimen
- Ricardo Buitrago
- Ricardo Martinez Zubieta
- Ricardo Matos
- Rick McAllister
- Rios F.
- Robba C.
- Robert Fowler
- Robyn Klages
- Rodrigo E Gómez-Paz
- Roger Lamoglie
- Rogério de Castro Pereira
- Roland Schneider
- Rolf Dembinski
- Rolf Rossaint
- Rollin Roldán Mori
- Romano Tetamo
- Román Garrido
- Ronald Pairumani
- Ronnie Mantilla
- Rosa Luz López Martínez
- Rosa Sebastián
- Rosa Álvaro
- Rosalba Tufano
- Rosanna Del Giudice
- Rosanna Vaschetto
- Rosario Urbino
- Rovílson Lara
- Rovílson Lara
- Rubens Altair Amaral de Pádua
- Rubén Camargo
- Rui Moreno
- Rupesh Vakil
- Ryan Albert
- Sabriye Guvenc
- Salem Ould Zein
- Salvatore Maurizio Maggiore
- Samer Haj-Bakri
- Samir Abdelhadi
- Samir Sahu
- Samir Vermani
- Sando Chavarria
- Sangeeta Mehta
- Sanjay Dhanuka
- Santiago Ilutovich
- Sara Cabañes
- Schimdt Alejandra
- Sebastian Circo
- Sebastián E Mare
- Serena Azzari
- Serge Heines
- Sergio Cáceres
- Sergio Lasdica
- Seton Henderson
- Shawna Reddie
- Sheila Nainan Myatra
- Shelby Sutton
- Sheree Gare
- Shirley Nelson
- Shouhong Wang
- Silke Frenzel
- Silvia Mareque
- Silvina Borello
- Silvio A Ñamendys-Silva
- Simon J G Hockley
- Simona Beniczky
- Sindhaghatta Venkatram
- Sine Wichman
- Smyth Smith
- Soares M. A.
- Sofía García
- Soraya Puertas
- Srinivas Samavedam
- Stambouli Neji
- Steffen Appel
- Steffen Weber-Carstens
- Stephanie Lubchansky
- Stephen Lapinsky
- Steven Y Chang
- Stevens Salva
- Subhash Kumar Todi
- Sujoy Mukherjee
- Susan Gillen
- Susana Alves Ferreira
- Susana Moradillo
- Susana Temprano
- Susanne Andi Iversen
- Sutherasan Y.
- Sutrisno Gunawan
- Sylvia den Boer
- Tania Caf
- Tarek Dendane
- Tayfun Adanir
- Tejerina E. E.
- Teresa Mut
- Teresa Sánchez de Dios
- Thille A. W.
- Thomas Bein
- Thomas Lipp
- Thomas Moellhoff
- Thomas Steinke
- Thoralf Kerner
- Tiehe Qin
- Tim Coles
- Tim Houlihan
- Timothy D Girard
- Tom Cowlam
- Tony Sutherland
- Tony Williams
- Travis Parry
- Troy Browne
- Tumbass Volker
- Uli Strauch
- Umesh G
- Unase Büyükkoçak
- V J Cardenas Jr
- Valentín Parra
- Valerio Mangani
- Valery Subbotin
- Valle Pinheiro B.
- Valéria de Carvalho Magela
- Vanesa Ramírez
- Vicente Arraez
- Victoria Goñi
- Vincent John Scott
- Vito Marco Ranieri
- Vivek Joshi
- Wajdi Maazouzi
- Walter Brandt
- Walter Seyde
- Wanxia Li
- Wei He
- Wei Yu
- Wei Zhang
- Weihai Yao
- William Rodriguez-Cintron
- Winfried Schubert
- Wolfgang Baier
- Won-Yeon Lee
- Xi Zhu
- Xianyao Wan
- Xiaobo Huang
- Xue Wang
- Yalin Liu
- Yan Kang
- Yangong Chao
- Yaseen Arabi
- Yi Li
- Yi Yang
- Yogeet Kaur
- Yongjie Yin
- Young Suh G.
- Younsuck Koh
- Yu Bai
- Yuan Xu
- Yuhong Guo
- Yun Seong Kim
- Yunxuan Yue
- Zafer Dogan
- Zalatiel Maycotte Luna
- Zaza Cohen
- Zhengxuan Lv
- Zhenjie Hu
- Zhenyang He
- Zhicheng Zhang
- Zhihua Hu
- Zhixiang Li
- Zoltan Szentkereszty
- Zoraida Parra
- Zsolt Molnar
- Ángela Alonso
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/11/2021
- Field of study
OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
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- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
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- Barbara Rizzardi
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- Becky Martinez
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- Surisday Mederos
- Susan Jeanfreau
- Susan Kline
- Susan L. Koletar
- Susan Parker
- Susanne Doblecki-Lewis
- Suzanna Studdard
- Suzanne Fiorillo
- Suzanne Gharib
- Suzanne Swan
- Sybil G. Hosek
- Szheckera Fearon
- Tamara Richards
- Tambra Dora
- Tameika Scott
- Tami Wahlin
- Tammi L. Shlotzhauer
- Tana Bourgeois
- Tanya Hutchins
- Taryn Petty
- Tatiana Beresnev
- Tavane Harrison
- Taylor Nelson
- Teletha Gipson
- Teresa A. Batteiger
- Teresa Becker
- Teresa Deese
- Teresa S. Sligh
- Teri Thompson-Seim
- Terri Moye
- Terry D. Klein
- Terry L. Poling
- Terry Piedra
- Theresa Hegmann
- Thomas B. Campbell
- Thomas C. Klein
- Thomas C.S. Martin
- Thomas Mellman
- Thomas Patterson
- Thomas Weiss
- Tiffany Esinhart
- Tiffany Nemecek
- Tiffany Schwasinger-Schmidt
- Tilly Varughese
- Timothy J. Hatlen
- Timothy P. Vachris
- Timothy Shope
- Timothy W. Schacker
- Timothy Wilkin
- Tina Tong
- Tina Wang
- Toby Briskin
- Todd Simmons
- Tom Fiel
- Toni Robinson
- Toni White
- Tracy Okonya
- Tracy R. Klein
- Trina L. Reynolds
- Troy Holdeman
- Tyler D. Bold
- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
- Veronica G. Fragoso
- Veronica Garcia-Fragoso
- Veronica Procasky
- Veronica Viar
- Vicki E. Miller
- Vickie Leathers
- Victoria Andriulis
- Victoria Engler
- Victoria Mosteller
- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
- Vincent Huynh
- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
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Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
- Baden Lindsey R.
- Badillo Diana
- Bainbridge Emma
- Baka Michele
- Baker Sherrie
- Balani Bindu
- Ball Brandy
- Bances Karla Beatriz Tafur
- Baron Mira
- Barranco-Santana Elizabeth
- Bartilucci Darlene
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- Sadoff Jerald
- Saemann Michelle
- Safirstein Beth
- Saldaña Eduardo Gabriel Vázquez
- Saleem Nafisa
- Saleh Jamshid
- Sales Kacie
- Salzl Amy
- Sample Denise
- Samuels Robert
- Sanchez Erica
- Sanchez Martha
- Sanchez Rosario
- Sanchez-Crespo Nelia
- Sanders John
- Sanders Lisa J.
- Santiago Fredric
- Santiago Rica
- Santolaya María E.
- Scatamacchia Carolyn
- Schacker Timothy W.
- Schipani Linda M.
- Schmeck Christy
- Schmidt Robert
- Schnitz William
- Schroeck Debra B.
- Schwartz Adam
- Schwartz Howard
- Schwartz Howard I.
- Schwartz Jennifer
- Schwasinger-Schmidt Tiffany
- Sciaudone Michael
- Scott Hyman
- Scott Tameika
- Secord Elizabeth
- Segall Nathan
- Seger William
- Seversen Shannen
- Sha Beverly E.
- Shah Mitul
- Shairi Samira
- Shankaran Shivanjali
- Shannon Amie
- Shapiro Adrienne E.
- Sharp Stephan C.
- Shaw Marian E.
- Shelly Rozeli
- Shelton Sandra
- Sherman Amy
- Sheth Neil P.
- Shinn Steven
- Shlotzhauer Tammi L.
- Shope Timothy
- Shopsin Bo
- Shoptaw Steven
- Siddiqui Farhan
- Siegel Marc
- Sierra Dianca
- Silver William P.
- Simmons Todd
- Simon Gary
- Sims Matthew D.
- Singer Leonard
- Singletary Justin
- Skipper Stephanie
- Slechta Stacy
- Sligh Teresa S.
- Smith Candace
- Smith Derek M.
- Smith Katherine
- Smith Mary
- Smith Michael J.
- Smith William B.
- Snell Kimberly
- Sobhanie M. Mahdee
- Sobieszczyk Magdalena E.
- Sogbetun Obiageli
- Solis Joel
- Sonnier Cora
- Sopher Carrie
- Sovic Brit
- Spector Stephen A.
- Sperber Steven
- Staben Jonathan
- Stahl Jessica
- Stanford Amber
- Stangl Lisa
- Stanton Ariana C.
- Stapleton Jack
- Stapleton Katherine
- Starlin Richard
- Starr Amy
- Starr Ryan P.
- Steil Kenneth
- Stephenson Carolene
- Stephenson Kathryn E.
- Sterling Stephanie
- Stewart Brittany
- Striker Robert
- Strout Cynthia Becher
- Struyf Frank
- Studdard Suzanna
- Stulken Laura
- Stull Mildred
- Sturgeon Rodney E.
- Suen May-Yin
- Sugimoto Danny
- Suyehira Janice
- Swaminathan Shobha
- Swan Suzanne
- Swann Edith
- Swanson Austin
- Sweet Christy
- Swieboda Elisa
- Syndergaard Scott N.
- Takizala Zudi-Mwak
- Takuva Simbarashe G.
- Talaat Kawsar R.
- Tan Chen S.
- Tapia Milagritos
- Tarakjian Denis
- Tashima Karen
- Tatelbaum David
- Taylor Barbara S.
- Taylor Brandie
- Tedder-Edwards Sharita
- Teherani Meghan
- Theodore Deborah A.
- Thessing Jeffrey
- Thomas Meagan
- Thomas-Seaton LaTeshia
- Thompson Amy
- Thompson Karl M.
- Thompson-Seim Teri
- Thomsen Isaac
- Tieu Hong V.
- Toma Ramy J.
- Tomaszewski Christian
- Tomatsu Lee
- Tomlinson Ryan
- Tong Tina
- Tong Xiaomi
- Torres Juan P.
- Torres Julian A.
- Tovar Dalia
- Tran Carolyn
- Treanor John J.
- Tukuru Sade
- Turley Christine B.
- Turner Mark A.
- Tyson Stefanie
- Ulrich Robert J.
- Usdan Lisa S.
- Utz Gregory C.
- Vachris Timothy P.
- Valenti Bruno
- Valika Insiya
- Van Der Leden Mimi
- Van Dromme Ilse
- Van Ever Wesley
- Van Roey Griet
- Varughese Tilly
- Vega Jocelyn Zuleica Olmos
- Vega Norma
- Vegas Diana
- Vertucci Michele
- Viar Veronica
- Viens Nicholas A.
- Villegas Marysol
- Vingerhoets Johan
- Vogler Mary
- Vowell Mandy
- Vrbicky Keith W.
- Wahlin Tami
- Wakefield Paul H.
- Wald Anna
- Walker James
- Walker Shannon
- Walsh Edward E.
- Walsh Mary C.
- Walsh Stephen R.
- Walsh Stephen R.
- Walter Emmanuel B.
- Walters Ayanna
- Wang Tina
- Warden Ashley
- Waters Michael
- Watkins Breanz
- Webb Angella
- Webster Hala
- Weidler Jessica L.
- Weiss Thomas
- Wells Margaret
- Wendell Lewis III
- Wendrow Andrea
- Werne Melody
- West Whitney
- Whatley Jordan L.
- Whitaker Jennifer A.
- White Jewel J.
- White Julie
- White Toni
- Wijewardane Priyantha N.
- Wilkin Timothy
- Wilkinson Bethanie
- William S. Davis Jr
- Williams Barton G.
- Williams Hayes
- Williams Samantha
- Wilson Christine
- Wilson Clint
- Wilson Greg
- Wilson Natasha
- Winbigler Jennifer
- Winkle Peter J.
- Winokur Patricia L.
- Witbeck John
- Wohl David
- Woo Wayne
- Woodside Leana
- Wortman Glenn
- Wu Yi H.
- Wylie Paul E.
- Yang Fan
- Yang Kinara S.
- Yoon Anelgine C.
- York Jill
- Young Cheryl
- Yu Chenchen
- Yusin Joseph
- Zapata Luz
- Zash Rebecca
- Zegarra Eneyda Giuvanela Llerena
- Zemanek Arthur L.
- Zenlea Kate
- Zepeda Karla
- Zervos Marcus J.
- Zhai Nan
- Zhang Kevin
- Zhou James
- Zimmer Andrea
- Zingman Barry S.
- Zorrilla Carmen D.
- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- Abellán Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Özlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia González
- Aleem Muhammad
- Alegre Inês
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz Amorós
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-Díez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado Fabíola
- Amador Cristina García
- Amanullah Nazli
- Amaral Hélida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- Andrés Beatriz Díaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- Aşkar Ahmet
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia Fernández
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
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- Baldi Claudio
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- Balfour James
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- Bayo José Manuel Muros
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- Beznosenko Andriy
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- Bonci Eduard-Alexandru
- Bordom Daniel Osei
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- Boschiero Matheus Negri
- Bose Bodhisattva
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- Boudjenan-Serradj Nabil
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- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
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- Brandström Gustav
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- Bredikhin Mikhail
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- Bywater Edward
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- Bælum Jens Kristian
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- Cabrera Claudia
- Cafranga Estíbaliz Gutiérrez
- Cagnazzo Federica
- Calabria Mariangela
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- Caliendo Domenico
- Calin Camelia
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- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
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- Canals Lucía Otazu
- Canda Aras Emre
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- Cao Victor Hugo Bruno
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- Capusan Alina
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- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
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- Carvello Michele
- Casanova Daniel
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- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta Roselló
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
- Cirocchi Nicholas
- Ciubotaru Cezar
- Ciulli Cristina
- Ck Harikumar
- Clark Thomas
- Clarke Nicola
- Coccolini Federico
- Codes Lina
- Coelho Ana Margarida
- Cois Alessandro
- Coladonato Massimiliano
- Colak Elif
- Coldwell Chris
- Collins Jen
- Colombo Francesco
- Colás-Ruiz Enrique
- Conceição Luis
- Conde Juan Guillermo Ais
- Connolly Lewis
- Conversano Ivana
- Convertini Ornella
- Cook Esther
- Cooke Fiachra
- Coppolino Francesco
- Coratti Francesco
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- Crescentini Giacomo
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- Crisan Dana
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- Cruz Isabela
- Cucinotta Eugenio
- Cuichan Marco Vinicio Yugsi
- Cullinane Carolyn
- Cuneo Davide
- Cunha Miguel
- Curbelo Jacqueline
- Curcio Silvia
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- Currà Maria Cristina
- Currás Rosana Pérez
- Custódio Pedro
- Cutellè Clelia
- Czarnecki Roman
- D'Angelo Salvatore
- D'Ugo Stefano
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- da Silveira Sete Alexandre
- Dainius Edvinas
- Dalton Richard
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- Danassi Despoina
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- Daniels Ian R
- Daniyan Muhammad
- Danna Riccardo
- Danys Donatas
- Dardanov Dragomir
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- Dassanayake Vihara
- Daugėla Edvardas
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- Davis Cian
- Dawson Brett E
- Dawson Carmel
- de Andrés-Asenjo Beatriz
- de Deken Julie
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- de León Rendón Jorge Luis
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- en Siew Bei
- Ene-Cocis Mihaela-Valentina
- Eng Stanley Chee Ren
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- Erdmann Thomas Rolf
- Erginöz Ergin
- Ergün Sefa
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- Espino Julieta
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- Feiss Anna
- Felix Michael Shalzim
- Feo Carlo V
- Ferlengez Aysegul
- Fermani Claudio
- Fernandes Andre
- Fernandes Vania
- Fernandez Eugenia
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- Fernández Begoña Fadrique
- Fernández Ignacio Ortega
- Fernández-Arias Sebastian
- Fernández-Hevia Maria
- Fernández-Martínez Daniel
- Ferrario Luca
- Ferraz Teresa
- Ferreira Andreia
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- Zayakov Georgi
- Zaycev Andrey
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- Zazo Rama
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- Zengin Abdullah Kağan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
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- Ângelo Miguel Duarte
- ÓSullivan Sara Nuñez
- Özçelik Mehmet Faik
- Ćoza Ivo
- Şanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)