431 research outputs found

    Monolithic Bidirectional Switch Based on GaN Gate Injection Transistors

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    The paper deals with a bi-directional switch based on N-channel enhancement-mode GaN FET. The proposed device is a Gate Injection Transistor monolithic solution to reduce the volume of the switch with high current density and blocking voltage of 600V. It features a dual-gate control pin and two power terminal. In the paper, the main characteristics of the bi-directional switch and the performance in the four-quadrant of operation are examined and discussed. The device characteristics are compared with the traditional MOSFET and IGBT solutions. The gate driver design issues are considered to optimize the switching transient of the GaN-based switch. Finally, an experimental evaluation of the GaN FET as the bidirectional circuit breaker is carried out in an AC power supply system to validate the effectiveness of the proposed monolithic new device

    Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain

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    We demonstrated a role for the Mg2 + transporter TRPM7, a bifunctional protein with channel and α-kinase domains, in aldosterone signaling. Molecular mechanisms underlying this are elusive. Here we investigated the function of TRPM7 and its α-kinase domain on Mg2 + and pro-inflammatory signaling by aldosterone. Kidney cells (HEK-293) expressing wild-type human TRPM7 (WThTRPM7) or constructs in which the α-kinase domain was deleted (ΔKinase) or rendered inactive with a point mutation in the ATP binding site of the α-kinase domain (K1648R) were studied. Aldosterone rapidly increased [Mg2 +]i and stimulated NADPH oxidase-derived generation of reactive oxygen species (ROS) in WT hTRPM7 and TRPM7 kinase dead mutant cells. Translocation of annexin-1 and calpain-II and spectrin cleavage (calpain target) were increased by aldosterone in WT hTRPM7 cells but not in α-kinase-deficient cells. Aldosterone stimulated phosphorylation of MAP kinases and increased expression of pro-inflammatory mediators ICAM-1, Cox-2 and PAI-1 in Δkinase and K1648R cells, effects that were inhibited by eplerenone (mineralocorticoid receptor (MR) blocker). 2-APB, a TRPM7 channel inhibitor, abrogated aldosterone-induced Mg2 + responses in WT hTRPM7 and mutant cells. In 2-APB-treated ΔKinase and K1648R cells, aldosterone-stimulated inflammatory responses were unchanged. These data indicate that aldosterone stimulates Mg2 + influx and ROS production in a TRPM7-sensitive, kinase-insensitive manner, whereas activation of annexin-1 requires the TRPM7 kinase domain. Moreover TRPM7 α-kinase modulates inflammatory signaling by aldosterone in a TRPM7 channel/Mg2 +-independent manner. Our findings identify novel mechanisms for non-genomic actions of aldosterone involving differential signaling through MR-activated TRPM7 channel and α-kinase

    Transition in incompressible boundary layers with two-dimensional excrescences

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    An experimental investigation of the transition process in boundary layers subjected to forward- or aft-facing two-dimensional step excrescences is described. The objective of the work was to characterize the variation of transition Reynolds numbers with measurable roughness and boundary layer parameters, with the specific goal of specifying new tolerance criteria for laminar flow airfoils, alongside a fundamental investigation of linear boundary layer stability mechanisms. Results from an ongoing program of increasing complexity on effects of pressure gradient on excrescence-induced transition are presented. Preliminary N-factor calculations are used to determine the effects of boundary layer stability and attempt to isolate the effect of the disturbance due to the excrescence

    Deep learning for monthly rainfall–runoff modelling: a large-sample comparison with conceptual models across Australia

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    A deep learning model designed for time series predictions, the long short-term memory (LSTM) architecture, is regularly producing reliable results in local and regional rainfall–runoff applications around the world. Recent large-sample hydrology studies in North America and Europe have shown the LSTM model to successfully match conceptual model performance at a daily time step over hundreds of catchments. Here we investigate how these models perform in producing monthly runoff predictions in the relatively dry and variable conditions of the Australian continent. The monthly time step matches historic data availability and is also important for future water resources planning; however, it provides significantly smaller training datasets than daily time series. In this study, a continental-scale comparison of monthly deep learning (LSTM) predictions to conceptual rainfall–runoff (WAPABA model) predictions is performed on almost 500 catchments across Australia with performance results aggregated over a variety of catchment sizes, flow conditions, and hydrological record lengths. The study period covers a wet phase followed by a prolonged drought, introducing challenges for making predictions outside of known conditions – challenges that will intensify as climate change progresses. The results show that LSTM models matched or exceeded WAPABA prediction performance for more than two-thirds of the study catchments, the largest performance gains of LSTM versus WAPABA occurred in large catchments, the LSTMs struggled less to generalise than the WAPABA models (e.g. making predictions under new conditions), and catchments with few training observations due to the monthly time step did not demonstrate a clear benefit with either WAPABA or LSTM.</p

    Turing Instability in a Boundary-fed System

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    The formation of localized structures in the chlorine dioxide-idodine-malonic acid (CDIMA) reaction-diffusion system is investigated numerically using a realistic model of this system. We analyze the one-dimensional patterns formed along the gradients imposed by boundary feeds, and study their linear stability to symmetry-breaking perturbations (Turing instability) in the plane transverse to these gradients. We establish that an often-invoked simple local linear analysis which neglects longitudinal diffusion is inappropriate for predicting the linear stability of these patterns. Using a fully nonuniform analysis, we investigate the structure of the patterns formed along the gradients and their stability to transverse Turing pattern formation as a function of the values of two control parameters: the malonic acid feed concentration and the size of the reactor in the dimension along the gradients. The results from this investigation are compared with existing experiments.Comment: 41 pages, 18 figures, to be published in Physical Review

    Transitions/relaxations in polyester adhesive/PET system

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    The correlations between the transitions and the dielectric relaxation processes of the oriented poly(ethylene terephthalate) (PET) pre-impregnated of the polyester thermoplastic adhesive have been investigated by differential scanning calorimetry (DSC) and dynamic dielectric spectroscopy (DDS). The thermoplastic polyester adhesive and the oriented PET films have been studied as reference samples. This study evidences that the adhesive chain segments is responsible for the physical structure evolution in the PET-oriented film. The transitions and dielectric relaxation modes’ evolutions in the glass transition region appear characteristic of the interphase between adhesive and PET film, which is discussed in terms of molecular mobility. The storage at room temperature of the adhesive tape involves the heterogeneity of the physical structure, characterized by glass transition dissociation. Thus, the correlation between the transitions and the dielectric relaxation processes evidences a segregation of the amorphous phases. Therefore, the physical structure and the properties of the material have been linked to the chemical characteristics

    New insights into atmospherically relevant reaction systems using direct analysis in real-time mass spectrometry (DART-MS)

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    The application of direct analysis in real-time mass spectrometry (DART-MS), which is finding increasing use in atmospheric chemistry, to two different laboratory model systems for airborne particles is investigated: (1) submicron C3–C7 dicarboxylic acid (diacid) particles reacted with gas-phase trimethylamine (TMA) or butylamine (BA) and (2) secondary organic aerosol (SOA) particles from the ozonolysis of α-cedrene. The diacid particles exhibit a clear odd–even pattern in their chemical reactivity toward TMA and BA, with the odd-carbon diacid particles being substantially more reactive than even ones. The ratio of base to diacid in reacted particles, determined using known diacid–base mixtures, was compared to that measured by high-resolution time-of-flight aerosol mass spectrometry (HR-ToF-AMS), which vaporizes the whole particle. Results show that DART-MS probes  ∼  30 nm of the surface layer, consistent with other studies on different systems. For α-cedrene SOA particles, it is shown that varying the temperature of the particle stream as it enters the DART-MS ionization region can distinguish between specific components with the same molecular mass but different vapor pressures. These results demonstrate the utility of DART-MS for (1) examining reactivity of heterogeneous model systems for atmospheric particles and (2) probing components of SOA particles based on volatility

    Phase Dynamics of Nearly Stationary Patterns in Activator-Inhibitor Systems

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    The slow dynamics of nearly stationary patterns in a FitzHugh-Nagumo model are studied using a phase dynamics approach. A Cross-Newell phase equation describing slow and weak modulations of periodic stationary solutions is derived. The derivation applies to the bistable, excitable, and the Turing unstable regimes. In the bistable case stability thresholds are obtained for the Eckhaus and the zigzag instabilities and for the transition to traveling waves. Neutral stability curves demonstrate the destabilization of stationary planar patterns at low wavenumbers to zigzag and traveling modes. Numerical solutions of the model system support the theoretical findings
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