Action de l'insuline sur le métabolisme du cholestérol et des acides biliaires chez le Hamster (rôle dans l'induction de la lithiase biliaire cholestérolique)

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

Les CLA peuvent-ils prévenir l'athérogenèse ?

National audienc

The natural concentration of the conjugated linoleic acid, cis-9, trans-11 in milk-fat can modulate the atherogenic risk in hyperlipidemic hamsters

International audienc

The natural concentration of the conjugated linoleic acid, cis-9,trans-11, in milk fat has antiatherogenic effects in hyperlipidemic hamsters

International audienc

Les CLA peuvent-ils prévenir l’athérogenèse ?

The anti-atherogenic properties of CLA are now illustrated in many animal studies (Rabbit, Mice and Hamster) or cell culture experiments. These properties can be observed while using either the CLA isomeric mixture (cis9,trans11- and trans10,cis12-, 50 :50) or selected CLA isomers (cis9,trans11- or trans10,cis12-). Especially, these fatty acids consistently attenuate the outcome of primary vascular lesions (fatty streaks), or can even induce a regression of pre-established lesions. There is, paradoxically, no clear relationship between this beneficial effect and an improvement of the lipid status in blood (triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol) usually considered as a hallmark in the etiology of atherosclerosis. On the other hand, recent data obtained both in vitro and in vivo indicate that part of the beneficial effects of CLA occurs through the modulation of vascular inflammatory and oxidant stress factors (cytokines and cyclooxygenase), as well as from the expression of adhesion molecules (VCAM, ICAM) in the aorta. This regulation involves the interaction of CLA with transcription factors such as PPARs, LXR and NF-kB targeting the gene expression dowstream. In human, clinical trials are no more conclusive than the animal experiments with regards to the contribution of CLA to modulate the lipid status in blood. Nevertheless, some data highlight the pro-atherogenic role of CLA and especially of the trans10,cis12-isomer, as demonstrated by the increase in the various markers of oxidative stress (isoprostanes) and inflammatory status (C-reactive protein). In conclusion, whereas there is compelling evidence that feeding mixed or pure isomers of CLA attenuates atherosclerosis initiation and progression in several experimental models, human studies are less convincing. Nevertheless, clinical trials addressing sufficient risk factors and risk markers together are still lacking to draw a definitive conclusion and to set up obvious recommandations. The use of the sole blood lipids do not seem to be appropriate for such an evaluation

Long-term consequences of maternal high-fat diet on hypothalamic leptin sensitivity and diet-induced obesity in the offspring

National audienc

Long-term consequences of maternal high-fat diet on hypothalamic leptin sensitivity and diet-induced obesity in the offspring

National audienc

SISTEM KEAMANAN RUMAH BERBASIS ANDROID DENGAN RASBERRY Pi

Smart Home is one of the tools that is developed for ease of automation of smart home management from the start of address, security, comfort, savings, through automation with Android. In designing a micro home security system controller using raspberry pi 3 and Android smartphones that can reduce the number of criminal acts of burglary door. This tool consists of an electro magnetic door lock called a solenoid door lock.This solenoid key is placed on the door of the house for security. The design of this home door security system utilizes Raspberyy pi b + as a control device from near and far by utilizing the wifi network and sms gateway to control opening and closing the home door lock that is controlled via an android mobile. Through web bootstrap that will display the results captured by the camera to provide a home situation every time someone enters.This house door security system that has been successfully built and tested with the working principle if there is someone who forces or breaks the house door in a closed condition, the system will activate a warning or alarm by sounding the buzzer¸ because there is an LDR sensor connected to one switch connected to the solenoid key that results, if the key is opened with a security system then the LDR sensor will turn off and there will be no alarm, but if it is forced to break the LDR sensor will activate and read the movement of the door so that the reaction occurs and the buzzer alarm will sound. This security system is a solution to increase the level of home security ¸ besides this sophisticated system is very easy to use and integrated with android smartphone

Les CLA peuvent-ils prévenir l’athérogenèse ?

National audienc

Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring.

International audienceEpidemiological and animal studies suggest that the alteration of hormonal and metabolic environment during fetal and neonatal development can contribute to development of metabolic syndrome in adulthood. In this paper, we investigated the impact of maternal high-fat (HF) diet on hypothalamic leptin sensitivity and body weight gain of offspring. Adult Wistar female rats received a HF or a control normal-fat (C) diet for 6 wk before gestation until the end of the suckling period. After weaning, pups received either C or HF diet during 6 wk. Body weight gain and metabolic and endocrine parameters were measured in the eight groups of rats formed according to a postweaning diet, maternal diet, and gender. To evaluate hypothalamic leptin sensitivity in each group, STAT-3 phosphorylation was measured in response to leptin or saline intraperitoneal bolus. Pups exhibited similar body weights at birth, but at weaning, those born to HF dams weighed significantly less (-12%) than those born to C dams. When given the HF diet, males and females born to HF dams exhibited smaller body weight and feed efficiency than those born to C dams, suggesting increased energy expenditure programmed by the maternal HF diet. Thus, maternal HF feeding could be protective against adverse effects of the HF diet as observed in male offspring of control dams: overweight (+17%) with hyperleptinemia and hyperinsulinemia. Furthermore, offspring of HF dams fed either C or HF diet exhibited an alteration in hypothalamic leptin-dependent STAT-3 phosphorylation. We conclude that maternal high-fat diet programs a hypothalamic leptin resistance in offspring, which, however, fails to increase the body weight gain until adulthood