Decision-making and Other Influences on Adolescents' First Sexual Experience, and Its Impact

This study was looking at one's First Sexual Experience, which was defined as only intercourse both for heterosexual and same-sex relationships, and the circumstances surrounding it. Such circumstances were how different decision-making tactics; such as who the person was, or the reasons for initiation; one's emotions as a result of this experience (positive or negative); and the differences that appeared along gender lines. We wanted to know how they all interacted and thus affected how the individual felt about this first person and experience looking back, and if that was more significant than others since, and thus its overall impact on one's view of sex today. Contrary to our hypothesis, most of the subjects did not feel more strongly about this person and 1st sexual experience overall, when looking back, despite most considering it a positive experience

The pumpistor: a linearized model of a flux-pumped SQUID for use as a negative-resistance parametric amplifier

We describe a circuit model for a flux-driven SQUID. This is useful for developing insight into how these devices perform as active elements in parametric amplifiers. The key concept is that frequency mixing in a flux-pumped SQUID allows for the appearance of an effective negative resistance. In the three-wave, degenerate case treated here, a negative resistance appears only over a certain range of allowed input signal phase. This model readily lends itself to testable predictions of more complicated circuits.Comment: 4 pages, 3 figure

Characterization of a multimode coplanar waveguide parametric amplifier

We characterize a novel Josephson parametric amplifier based on a flux-tunable quarter-wavelength resonator. The fundamental resonance frequency is ~1GHz, but we use higher modes of the resonator for our measurements. An on-chip tuning line allows for magnetic flux pumping of the amplifier. We investigate and compare degenerate parametric amplification, involving a single mode, and nondegenerate parametric amplification, using a pair of modes. We show that we reach quantum-limited noise performance in both cases, and we show that the added noise can be less than 0.5 added photons in the case of low gain

Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study.

BackgroundOmega-3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies did not use treatment doses (3.36 g) of omega-3 fatty acids. Arterial stiffness measured by pulse wave velocity (PWV) predicts CVD events independent of standard risk factors. However, no therapy has been shown to reduce PWV in a blood pressure-independent manner. We assessed the effects of esterified omega-3 fatty acids on PWV and serum markers of inflammation among patients with hypertension.Design and methodsWe performed a prospective, randomized; double-blinded pilot study of omega-3 fatty acids among 62 patients in an urban, safety net hospital. Patients received 3.36 g of omega-3 fatty acids vs. matched placebo daily for 3-months. The principal outcome measure was change in brachial-ankle PWV. Serum inflammatory markers associated with CVD risk were also assessed.ResultsThe majority (71 %) were of Latino ethnicity. After 3-months, mean change in arterial PWV among omega-3 and placebo groups was -97 cm/s vs. -33 cm/s respectively (p = 0.36 for difference, after multivariate adjustment for baseline age, systolic blood pressure, and serum adiponectin). Non-significant reductions in lipoprotein-associated phospholipase A2 (LpPLA2) mass and high sensitivity C-reactive protein (hsCRP) relative to placebo were also observed (p = 0.08, and 0.21, respectively).ConclusionHigh-dose omega-3 fatty acids did not reduce arterial PWV or markers of inflammation among patients within a Latino-predominant population with hypertension.Clinical trial registrationNCT00935766 , registered July 8 2009

Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder.

Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy. GE changes in peripheral blood are desirable because they can be assessed easily on multiple occasions during treatment. We report here on GE changes in 68 individuals who were treated for 8 weeks with either escitalopram alone, or escitalopram followed by bupropion. GE changes were assessed after 1, 2, and 8 weeks of treatment, with significant changes observed in 156, 121, and 585 peripheral blood gene transcripts, respectively. Thirty-one transcript changes were shared between the 1- and 8-week time points (seven upregulated, 24 downregulated). Differences were detected between the escitalopram- and bupropion-treated subjects, although there was no significant association between GE changes and clinical outcome. A subset of 18 genes overlapped with those previously identified as differentially expressed in subjects with MDD compared with healthy control subjects. There was statistically significant overlap between genes differentially expressed in the current and previous studies, with 10 genes overlapping in at least two previous studies. There was no enrichment for genes overexpressed in nervous system cell types, but there was a trend toward enrichment for genes in the WNT/β-catenin pathway in the anterior thalamus; three genes in this pathway showed differential expression in the present and in three previous studies. Our dataset and other similar studies will provide an important source of information about potential biomarkers of recovery and for potential dysregulation of GE in MDD

Geometric phase around exceptional points

A wave function picks up, in addition to the dynamic phase, the geometric (Berry) phase when traversing adiabatically a closed cycle in parameter space. We develop a general multidimensional theory of the geometric phase for (double) cycles around exceptional degeneracies in non-Hermitian Hamiltonians. We show that the geometric phase is exactly $\pi$ for symmetric complex Hamiltonians of arbitrary dimension and for nonsymmetric non-Hermitian Hamiltonians of dimension 2. For nonsymmetric non-Hermitian Hamiltonians of higher dimension, the geometric phase tends to $\pi$ for small cycles and changes as the cycle size and shape are varied. We find explicitly the leading asymptotic term of this dependence, and describe it in terms of interaction of different energy levels.Comment: 4 pages, 1 figure, with revisions in the introduction and conclusio

A tunable coupling scheme for implementing high-fidelity two-qubit gates

The prospect of computational hardware with quantum advantage relies critically on the quality of quantum gate operations. Imperfect two-qubit gates is a major bottleneck for achieving scalable quantum information processors. Here, we propose a generalizable and extensible scheme for a two-qubit coupler switch that controls the qubit-qubit coupling by modulating the coupler frequency. Two-qubit gate operations can be implemented by operating the coupler in the dispersive regime, which is non-invasive to the qubit states. We investigate the performance of the scheme by simulating a universal two-qubit gate on a superconducting quantum circuit, and find that errors from known parasitic effects are strongly suppressed. The scheme is compatible with existing high-coherence hardware, thereby promising a higher gate fidelity with current technologies