HIBISCUS ROSA SINENSIS LOADED SOLID LIPID NANOPARTICLES AND IN VIVO WOUND HEALING ACTIVITY IN WISTAR ALBINO RATS

Objective: The objective of the present research was to investigate the wound-healing potency of solid lipid nano particles of Hibiscus rosa sinensis extract. Crude herbal extracts and rudimentary formulations containing herbal extracts are good for demonstrating the feasibility of the concept; however, such formulations suffer with poor oral bioavailability and variability within groups of subjects. Converting herbal extracts into novel drug delivery systems may prove effective in addressing some of these problems. Methods: In the present study an attempt was made to develop Hibiscus rosa sinensis extract loaded solid lipid nanoparticles (HSLNs) using lipids glycerol monostearate (GMS) or beeswax. The prepared HSLNs were characterised for their size, surface charge and morphology. The optimized HSLNs were incorporated into Carbopol gel and tested for wound healing activity in male Wistar albino rats using excision wound model. Results: HSLNs of ~175 nm in size carrying negative charge were obtained with the optimised procedure using beeswax. The shape of the HSLNs was nearly spherical. The HSLNs (10 mg/ml) treated wounds healed much faster compared to raw crude extract and healing was comparable to marketed preparation. Conclusion: It is concluded that converting crude herbal extracts into SLNs can be an effective way to enhance the effectiveness of herbal extracts and their in vivo activity

INTEND OF COAL MINE WEATHER MONITORING SYSTEM IN UNDERGROUND USING IOT PLATFORM

Just recently, the regular coal mine safety and security injuries have actually induced severe casualties as well as huge financial losses. It is immediate for the around the world mining business to development functional performance and also enhances typical mining security. This paper suggests a light-weight mashup middleware to accomplish remote monitoring as well as control automation of below ground physical sensing unit gadgets. Initially, the collection tree based upon Wireless Sensor Network is released in a below ground coal mine, as well as suggests an Open Service Gateway effort based consistent tools solve of entrance to structure. After that, support a consistent message location as well as stats circulation variation, as well as likewise, a light-weight solutions mashup technique is performed. With the aid of visualization period, the icon of various below ground physical sensing unit gadgets can be produced, which permits the sensing units to blend with various possessions quickly. Besides, 4 kind of coal mine safety and security monitoring and also control automation circumstances are detailed, as well as the general efficiency has actually furthermore been determined and also examined. It has actually been confirmed that our light-weight mashup middleware can minimize the expenditures successfully to produce coal mine security surveillance as well as take care of automation programs

SELF REFERENCED EDGE DETECTION FOR CMOS PWM TRANSCEIVER

Technique is used to implement the CMOS PWM Transceiver circuit is presented. In this paper, A Self Referenced Edge Detection technique is implemented to analyze a CMOS PWM Transceiver circuit, by comparing the rising edge that is self-delayed by about 0.5 T and the modulated falling edge in one carrier clock cycle. An Area-efficient and high robustness (against timing fluctuations) edge detection enabling PWM communication is achieved without requiring elaborate phase-locked loops. Self-referenced edge detection circuit has the capability of timing error measurement while changing the length of self delay element, adaptive data-rate optimization and delay-line calibration are realized. The measured results with a 65-nm CMOS prototype demonstrate a 2-bit PWM communication, high data rate (4Gbps), small peak to peak jitter(4.8ns), and high reliability (BER > 10−12) with small area occupation (540 μm2) and with high RMS (1.3). For reliability improvement, error check and correction associated with intercycle edge detection is introduced and its effectiveness is verified by 2-bit PWM measurement

AUTOMATED CUSTOMER TRAVELLING INFORMATION & PRICING METHODS

This paper describes a formula developed to implement the methodology and also the is a result of its application to bus service data from Porto. It proposes new spatial validation features to increase the precision of destination inference results and also to verify key presumptions contained in previous origin-destination estimation literature. The methodology is applicable to entry-only system designs coupled with distance-based fare structures, and it aims to boost raw AFC system data using the destination of individual journeys. Automated fare collection (AFC) systems are utilized in many urban trains and buses systems all over the world. Because the designation indicates, these are generally designed with the specific reason for automating the ticketing system, easing public transport use for travellers and adding efficiency to revenue collection procedures. Additionally, AFC systems are used to allow integrated ticketing across different public transport modes and operators in cities. A methodology for estimating the destination of passenger journeys from automated fare collection (AFC) system data is described. The information connect with an AFC system integrated by having an automatic vehicle location system that records transaction for every passenger boarding a bus, that contains attributes regarding the path, the automobile, and also the travel card used, combined with the sometime and the place that the journey started. A few of these are recorded with regards to permitting onboard ticket inspection but furthermore enable innovative spatial validation features created by the methodology. The outcomes brought to the conclusion the methodology works well for estimating journey destinations in the disaggregate level and identifies false positives reliably

Effect of biofertilizers and micronutrients on growth, leaf yield and quality of coriander (Coriandrum sativum L.) cv. Sadhana

A field experiment was conducted during rabi 2015-16 at Research Farm, College of Horticulture, Dr.Y.S.R. Horticultural University, Anantharajupeta (Andhra Pradesh), India, to study the effect of different biofertilizers and micronutrients on growth, leaf yield and quality of coriander (Coriandrum sativum L.) cv. Sadhana. The experiment was conducted in a factorial randomized block design with biofertilizers and micronutrients. The biofertilizer treatments were seed inoculation with Azospirillum, Phosphate Solubilising Bacteria (PSB), Azospirillum + Phosphate Solubilising Bacteria (PSB) and control (without any biofertilizer), while the micronutrient treatments comprised of foliar sprays of Zinc sulphate, Copper sulphate, Ferrous sulphate each at @ 0.5% and control (without any micronutrient). The sixteen treatment combinations were replicated thrice. Among the treatments, seed inoculation with Azospirillum + PSB+ foliar spray of zinc sulphate @ 0.5% recorded maximum plant height, number of primary branches, leaf area, fresh leaf yield per plant, leaf yield per plot, leaf yield per hectare, dry matter production, protein content, ascorbic acid content and moisture content. While, the lowest days to germination and leaf chlorophyll contents were recorded with the seed inoculation of Azospirillum + PSB + foliar spray of ferrous sulphate @ 0.5%

CHANGEABLE VEHICLES PATH MAP RELYING ON INTERCONTINENTAL DRIVERS

The brilliant mobility of vehicles also makes routing far complicated once we lack reliable way to infer the long run location of vehicles. However, when thinking about a genuine deployment, the idea of full understanding from the trajectories of vehicles appears impractical because it raises several privacy concerns. The FPF strategy demands partial mobility information, i.e., the power of vehicles inside the urban cells and also the migration ratios between all pairs of urban cells. FPF doesn't consider anyone information. In addition, processing the trajectories of vehicles needs a large computing effort, and gathering similarly info is way from trivial. The brilliant mobility of vehicles also makes routing far complicated once we lack reliable way to infer the long run location of vehicles. Within this work we advise a deployment formula according to migration ratios between urban cells without counting on the person vehicles trajectories. Among several optimization targets, we maximize the amount of distinct vehicles contacting the infrastructure, a fascinating metric whenever we plan to collect and disseminate small traffic bulletins. However, the amount of distant vehicles increases extremely fast once we escape from the chosen urban cell. During hurry hrs the main roads get congested and also the motorists use secondary roads as a substitute for getting away the congestions. The aim of FPF would be to select individual’s urban cells presenting the greatest quantity of uncovered vehicles. FPF might be expressed being an Integer Straight line Programming Formulation. Our goal would be to evaluate the outcome from the mobility info on the deployment performance. We validated our programs by applying the Integer Straight line Programming Formulation. Such result shows that previous understanding from the trajectories from the vehicles isn’t mandatory for achieving a detailed-to-optimal deployment performance whenever we plan to disseminate small traffic bulletins

CONTRIBUTE, DETACH AND AUTONOMOUS ACCESS TO CIPHER TEXT IN CLOUD DATABASE

In some approaches to repository functions have been adopted, while the approach to building trust in the message as a taboo of interests is being developed to be carefully dealt with. Having a pulse to swallow an embarrassing information usage ensures the withdrawal and implements the appropriate procedure in the encrypted message. Introducing the information, you need to distract yourself must confirm your trust, as well as an easy approach to the message. The car builds on popular encryption programs as well as unique ways to tune the encrypted data in hard to believe information into the shower. Secure confidential information acts as a basic job of creating a hacker to distract and discern irresponsibility, in addition to the gain measurement options, loss of unencrypted messages pointing to deformation Temporary and offer many options they detect the best way for tape information functions. The solid information prediction function does not retain anything legally right before the information has been previously benefited; it does not need any suggestion for the distraction function of the command

AN ORIGINAL CONTINUOUS CHECKING STRATEGY FOR BIOTIC PROPERTIES OF ILL ONES

We suggested a radio machine to machine healthcare solution that utilizes IPv6 techniques to determine the health problem of the sufferers. The M2M products are made and employed for the measurement of biomedical signals and sent to server machine through IP-enable internet and also the visualization module from the server program graphically demonstrate the recorded biomedical signals on android mobile. In the present paper, we're utilizing a novel idea for continuous monitoring patient's health problems. The care plan is concentrate on the measurement and monitoring various biological parameters of patient's body like heartbeat, oxygen saturation level in bloodstream and temperature utilizing a server and android application, where physician can continuously monitor a person's condition on his wise phone utilizing an Android application. Generally in critical situation patients should be supervised continuously for his or her SPOz, Heartbeat in addition to temperature. In the last techniques, the doctors have to be present physically or perhaps in several cases SMS is going to be sent using GSM. In the last situation a brief history from the patient can't be displayed, only current information is displayed. As well as the patient history is going to be stored on the internet server and physician have access to the data whenever needed everywhere and want not physically present

A STUDY ON FINANCIAL RISK AT FOOD AND HOSPITALITY INDUSTRY FOOD AND HOSPITALITY SERVICES

This article explores the critical issue of financial risk management within the context of Food and hospitality industry Food and Hospitality Services, a dynamic player in the food and hospitality industry. In today’s fast-paced and competitive business environment, financial risk is an ever-present concern that can significantly impact the stability and growth of an organization. Food and hospitality industry's success relies on its ability to adapt and proactively address financial risks to ensure long-term sustainability

Formulación y Optimización del Sistema Flotante de Amoxicilina para el tratamiento efectivo de la infección por Helicobacter pylori

The authors thank DST-FIST Lab (RERDS-CPR), R&D Director, for providing necessary facilities and assistance to perform this research work.Introducción: El objetivo del presente estudio fue formular y caracterizar el Sistema Flotante (FRS, siglas en Inglés) de Amoxicilina para prolongar el tiempo de residencia gástrica y liberación del fármaco para el enfoque efectivo del Helicobacter pylori. Método: Para el presente estudio se seleccionaron como factores goma guar, Monoestearato de glicerilo (GMS), carbonato de calcio. Como reacciones, se seleccionaros el período de congelación (h), el lapso de flotación (min), y el porcentaje acumulado de liberación del fármaco (CDR). Para la experimentación se seleccionaron el diseño factorial 23 con réplicas. Resultados: Se observó que la goma guar y el GMS fueron los factores principales que afectaron el período de congelación y mostraron un efecto sinérgico (positivo). Mientras que la goma guar y el carbonato de calcio mostraron un efecto positivo y el GMS mostró un efecto antagónico (negativo) en el lapso de flotación. El porcentaje CDR mostró un efecto antagónico en todos los factores. Se emplearon curvas de nivel para identificar el diseño del espacio, análisis numéricos posteriores produjeron 12 soluciones óptimas en base a la deseabilidad. El FRS mostró un mayor AUCo-t, Cmax, tmaxy t1/2 cuando se comparó con la formulación comercial, aproximadamente 2.30 cambios múltiplos y prolongación con liberación sostenida por más de 24 h que pudo deberse a una mejor congelación. Conclusiones: Se puede concluir que el sistema flotante se desarrolló satisfactoriamente por la aplicación del Diseño de Experimentos (DoE) con menores ensayos y utilizando fácilmente los excipientes disponibles para una mejor flotación, congelación y suministro constante del fármaco.Introduction: The aim of the present study was to develop and to characterize the floating raft system (FRS) of Amoxicillin to enhance gastric residence time and drug release to target Helicobacter pylori effectively. Method: In the present study, guar gum, glyceryl monostearate (GMS), calcium carbonate were selected as factors. Gelation duration (h), floating lag time (min), and % Cumulative drug release (CDR) were selected as responses. 23 factorial design with replicates was selected for experimentation. Results: It was observed that guar gum and GMS were the major factors affecting gelation duration, increase in the quantity of both guar gum and GMS increased gelation duration i.e., sustained gelation period (24 h). Floating time increased with an increase in the amount of guar gum and calcium carbonate, whereas an increase in the quantity of GMS decreased floating time. Guar gum, calcium carbonate, and GMS exhibited an antagonistic effect on % CDR. Contour plots were used to identify design space; further numerical analysis yielded 12 best solutions based on desirability. FRS exhibited greater AUCo-t, Cmax, tmax, and t1/2 when compared to marketed formulation approximately 2.30 folds enhancement and prolongation with a sustained release for greater than 24 h that might be due to better gelation. Conclusions: It can be concluded that the floating raft system was successfully developed by the Design of experiment (DoE) application with fewer trails and by utilizing easily available excipients for better floating, gelation, and sustained delivery of the drug