11,397 research outputs found
Scalable Unix Commands for Parallel Processors: A High-Performance Implementation
We describe a family of MPI applications we call the Parallel Unix Commands.
These commands are natural parallel versions of common Unix user commands such
as ls, ps, and find, together with a few similar commands particular to the
parallel environment. We describe the design and implementation of these
programs and present some performance results on a 256-node Linux cluster. The
Parallel Unix Commands are open source and freely available.Comment: 9 pages, 2 figure
Pipeline Implementations of Neumann-Neumann and Dirichlet-Neumann Waveform Relaxation Methods
This paper is concerned with the reformulation of Neumann-Neumann Waveform
Relaxation (NNWR) methods and Dirichlet-Neumann Waveform Relaxation (DNWR)
methods, a family of parallel space-time approaches to solving time-dependent
PDEs. By changing the order of the operations, pipeline-parallel computation of
the waveform iterates are possible without changing the final solution. The
parallel efficiency and the increased communication cost of the pipeline
implementation is presented, along with weak scaling studies to show the
effectiveness of the pipeline NNWR and DNWR algorithms.Comment: 20 pages, 8 figure
A Distributed and Incremental SVD Algorithm for Agglomerative Data Analysis on Large Networks
In this paper, we show that the SVD of a matrix can be constructed
efficiently in a hierarchical approach. Our algorithm is proven to recover the
singular values and left singular vectors if the rank of the input matrix
is known. Further, the hierarchical algorithm can be used to recover the
largest singular values and left singular vectors with bounded error. We also
show that the proposed method is stable with respect to roundoff errors or
corruption of the original matrix entries. Numerical experiments validate the
proposed algorithms and parallel cost analysis
Integrin α2β1 Expression Regulates Matrix Metalloproteinase-1-Dependent Bronchial Epithelial Repair in Pulmonary Tuberculosis.
Pulmonary tuberculosis (TB) is caused by inhalation of Mycobacterium tuberculosis, which damages the bronchial epithelial barrier to establish local infection. Matrix metalloproteinase-1 plays a crucial role in the immunopathology of TB, causing breakdown of type I collagen and cavitation, but this collagenase is also potentially involved in bronchial epithelial repair. We hypothesized that the extracellular matrix (ECM) modulates M. tuberculosis-driven matrix metalloproteinase-1 expression by human bronchial epithelial cells (HBECs), regulating respiratory epithelial cell migration and repair. Medium from monocytes stimulated with M. tuberculosis induced collagenase activity in bronchial epithelial cells, which was reduced by ~87% when cells were cultured on a type I collagen matrix. Matrix metalloproteinase-1 had a focal localization, which is consistent with cell migration, and overall secretion decreased by 32% on type I collagen. There were no associated changes in the specific tissue inhibitors of metalloproteinases. Decreased matrix metalloproteinase-1 secretion was due to ligand-binding to the α2β1 integrin and was dependent on the actin cytoskeleton. In lung biopsies, samples from patients with pulmonary TB, integrin α2β1 is highly expressed on the bronchial epithelium. Areas of lung with disrupted collagen matrix showed an increase in matrix metalloproteinases-1 expression compared with areas where collagen was comparable to control lung. Type I collagen matrix increased respiratory epithelial cell migration in a wound-healing assay, and this too was matrix metalloproteinase-dependent, since it was blocked by the matrix metalloproteinase inhibitor GM6001. In summary, we report a novel mechanism by which α2β1-mediated signals from the ECM modulate matrix metalloproteinase-1 secretion by HBECs, regulating their migration and epithelial repair in TB
Treatment of Clinical Perfectionism Using Acceptance and Commitment Therapy
Clinical perfectionism is characterized by rigidly pursuing unrealistically high standards on which self-worth is contingent and experiencing distress when these standards are not met. Because clinical perfectionism is associated with many psychological diagnoses, understanding how to treat it may help streamline available treatments. The aim of this dissertation was to test the effect of acceptance and commitment therapy (ACT), a cognitive-behavioral therapy, on 53 individuals with clinical perfectionism. Participants in the ACT group received 10 therapy sessions and those in the control group were on a waitlist for 14 weeks. The first study supported the effectiveness of ACT relative to the waitlist control group with respect to perfectionism severity, quality of life, and general symptom distress. The second study showed changes in psychological inflexibility and self-compassion explained improvements in quality of life and concern over mistakes, respectively. It also found a variable effect of baseline psychological inflexibility on response to treatment depending on the outcome tested. In contrast, average self-compassion was generally associated with better outcomes in ACT. Neurological results from the third study suggest receiving ACT was associated with greater cognitive efficiency while performing error-prone tasks and decreased responsivity to emotionally meaningful stimuli. In addition, changes in brain activation were not linked to changes in self-report outcomes. Collectively, this dissertation examined not only the efficacy of an intervention focused on a maladaptive behavioral pattern like clinical perfectionism but also how and for whom such a therapy works
Ferromagnetism below 10 K in Mn doped BiTe
Ferromagnetism is observed below 10 K in [Bi0.75Te0.125Mn0.125]Te. This
material has the BiTe structure, which is made from the stacking of two
Te-Bi-Te-Bi-Te blocks and one Bi-Bi block per unit cell. Crystal structure
analysis shows that Mn is localized in the Bi2 blocks, and is accompanied by an
equal amount of TeBi anti-site occupancy in the Bi2Te3 blocks. These TeBi
anti-site defects greatly enhance the Mn solubility. This is demonstrated by
comparison of the [Bi1-xMnx]Te and [Bi1-2xTexMnx]Te series; in the former, the
solubility is limited to x = 0.067, while the latter has xmax = 0.125. The
magnetism in [Bi1-xMnx]Te changes little with x, while that for
[Bi1-2xTexMnx]Te shows a clear variation, leading to ferromagnetism for x >
0.067. Magnetic hysteresis and the anomalous Hall Effect are observed for the
ferromagnetic samples.Comment: Accepted for publication in Phys. Rev.
- …