3 research outputs found
Brain, lung, and heart oxidative stress assessment of an over-the- counter pyrethroid insecticide product in Nigeria
We evaluated the brain, lung, and heart oxidative stress in rats exposed to aerosol of an over-thecounter pyrethroid insecticide product in Nigeria. The experimental animals were randomly divided into four groups: group I (control) was not exposed to the insecticide aerosol, while groups II, III, and IV were exposed to 6.0 mL m-3, 12.0 mL m-3, and 18 mL m-3 of insecticide aerosol respectively. Exposures were carried out in wooden-glass chambers one hour daily for six weeks. Malondialdehyde (MDA) andĀ reduced glutathione (GSH) concentrations, as well as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), andĀ glutathione S-transferase (GST) activities were determined. The brain, lung, and heart showed no significant difference in their weights and relative weights compared with the control. A significant increase in brain lipid peroxidation (LPO) was seen in groups III and IV, while there was no significant increase in lung and heart LPO compared with control. Significant decrease in the brain and lung GSH were observed in all the treatment groups when compared with the control, but only group IV showed significant reduction in heart GSH. Also, activities of lung GST and SOD were decreased compared with control, while the activity of GPx in the lung was significantly increased in group III. Lastly, nonsignificant increase in lung CAT activity was recorded in groups II and III, but decreased in group IV compared with control. Prolonged and incessant exposure to the insecticide aerosol over a long period of time may lead to tissue oxidative stress. These findings suggest that the use of insecticide aerosol for domestic purposes should be regulated.Keywords: Insecticide aerosol, pyrethroid, oxidative stress, lipid peroxidation, rats
Brain, lung, and heart oxidative stress assessment of an over-the-counter pyrethroid insecticide product in Nigeria
We evaluated the brain, lung, and heart oxidative stress in rats
exposed to aerosol of an over-the-counter pyrethroid insecticide
product in Nigeria. The experimental animals were randomly divided into
four groups: group I (control) was not exposed to the insecticide
aerosol, while groups II, III, and IV were exposed to 6.0 mL m-3, 12.0
mL m-3, and 18 mL m-3 of insecticide aerosol respectively. Exposures
were carried out in wooden-glass chambers one hour daily for six weeks.
Malondialdehyde (MDA) and reduced glutathione (GSH) concentrations, as
well as catalase (CAT), superoxide dismutase (SOD), glutathione
peroxidase (GPx), and glutathione S-transferase (GST) activities were
determined. The brain, lung, and heart showed no significant difference
in their weights and relative weights compared with the control. A
significant increase in brain lipid peroxidation (LPO) was seen in
groups III and IV, while there was no significant increase in lung and
heart LPO compared with control. Significant decrease in the brain and
lung GSH were observed in all the treatment groups when compared with
the control, but only group IV showed significant reduction in heart
GSH. Also, activities of lung GST and SOD were decreased compared with
control, while the activity of GPx in the lung was significantly
increased in group III. Lastly, non-significant increase in lung CAT
activity was recorded in groups II and III, but decreased in group IV
compared with control. Prolonged and incessant exposure to the
insecticide aerosol over a long period of time may lead to tissue
oxidative stress. These findings suggest that the use of insecticide
aerosol for domestic purposes should be regulated
Ethics and Responsible Conduct of Research: Workshop Report
The Center for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria , with support from its NIH Planning Grant organized a two Day workshop on āEthics and Responsible Conduct of Researchā at the University of Ibadan Centre for Sustainable Development (CESDEV). There were 8 facilitators and 78 participants. The workshop concluded that responsible conduct of research (RCR) is the practice of scientific investigation or research with integrity involving but not limited to the awareness and application of established professional norms and ethical principles in the performance of all activities related to scientific research