11,910 research outputs found
Monte Carlo Markov Chain parameter estimation in semi-analytic models of galaxy formation
We present a statistical exploration of the parameter space of the De Lucia and Blaizot version of the Munich semi-analytic (SA) model built upon the Millennium dark matter simulation. This is achieved by applying a Monte Carlo Markov Chain method to constrain the six free parameters that define the stellar and black hole mass functions at redshift zero. The model is tested against three different observational data sets, including the galaxy K-band luminosity function, B - V colours and the black hole-bulge mass relation, separately and combined, to obtain mean values, confidence limits and likelihood contours for the best-fitting model. Using each observational data set independently, we discuss how the SA model parameters affect each galaxy property and find that there are strong correlations between them. We analyse to what extent these are simply reflections of the observational constraints, or whether they can lead to improved understandings of the physics of galaxy formation.
When all the observations are combined, we find reasonable agreement between the majority of the previously published parameter values and our confidence limits. However, the need to suppress dwarf galaxy formation requires the strength of the supernova feedback to be significantly higher in our best-fitting solution than in previous work.
To balance this, we require the feedback to become ineffective in haloes of lower mass than before, so as to permit the formation of sufficient high-luminosity galaxies: unfortunately, this leads to an excess of galaxies around L*. Although the best fit is formally consistent with the data, there is no region of parameter space that reproduces the shape of galaxy luminosity function across the whole magnitude range.
For our best fit, we present the model predictions for the bJ-band luminosity and stellar mass functions. We find a systematic disagreement between the observed mass function and the predictions from the K-band constraint, which we explain in light of recent works that suggest uncertainties of up to 0.3 dex in the mass determination from stellar population synthesis models.
We discuss modifications to the SA model that might simultaneously improve the fit to the observed mass function and reduce the reliance on excessive supernova feedback in small haloes
Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease
Since their initial generation in the mid 1990s, transgenic mouse models of Alzheimers's disease (AD) have been proven to be valuable model systems which are indispensable for modern AD research. Whereas most of these models are characterized by extensive amyloid plaque pathology, inflammatory changes and often behavioral deficits, modeling of neuron loss was much less successful. The present paper discusses the current achievements of modeling neuron loss in transgenic mouse models based on APP/Aβ and Tau overexpression and provides an overview of currently available AD mouse models showing these pathological alterations
Thinking territory historically.
BACKGROUND:
While the randomised controlled trial (RCT) is generally regarded as the design of
choice for assessing the effects of health care, within the social sciences there is
considerable debate about the relative suitability of RCTs and non-randomised
studies (NRSs) for evaluating public policy interventions.
// OBJECTIVES:
To determine whether RCTs lead to the same effect size and variance as NRSs of
similar policy interventions; and whether these findings can be explained by other
factors associated with the interventions or their evaluation.
// METHODS:
Analyses of methodological studies, empirical reviews, and individual health and
social services studies investigated the relationship between randomisation and
effect size of policy interventions by:
1) Comparing controlled trials that are identical in all respects other than the use of
randomisation by 'breaking' the randomisation in a trial to create non-randomised
trials (re-sampling studies).
2) Comparing randomised and non-randomised arms of controlled trials mounted
simultaneously in the field (replication studies).
3) Comparing similar controlled trials drawn from systematic reviews that include
both randomised and non-randomised studies (structured narrative reviews and
sensitivity analyses within meta-analyses).
4) Investigating associations between randomisation and effect size using a pool of
more diverse RCTs and NRSs within broadly similar areas (meta-epidemiology).
// RESULTS:
Prior methodological reviews and meta-analyses of existing reviews comparing
effects from RCTs and nRCTs suggested that effect sizes from RCTs and nRCTs
may indeed differ in some circumstances and that these differences may well be
associated with factors confounded with design.
Re-sampling studies offer no evidence that the absence of randomisation directly
influences the effect size of policy interventions in a systematic way. No consistent
explanations were found for randomisation being associated with changes in effect
sizes of policy interventions in field trials
Intracellular Accumulation of Amyloid-Beta – A Predictor for Synaptic Dysfunction and Neuron Loss in Alzheimer's Disease
Despite of long-standing evidence that beta-amyloid (Aβ) peptides have detrimental effects on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely unclear. During the last years there is growing evidence that early intraneuronal accumulation of Aβ peptides is one of the key events leading to synaptic and neuronal dysfunction. Many studies have been carried out using transgenic mouse models of Alzheimer's disease (AD) which have been proven to be valuable model systems in modern AD research. The present review discusses the impact of intraneuronal Aβ accumulation on synaptic impairment and neuron loss and provides an overview of currently available AD mouse models showing these pathological alterations
Real-time determination of laser beam quality by modal decomposition
We present a real-time method to determine the beam propagation ratio M2 of
laser beams. The all-optical measurement of modal amplitudes yields M2
parameters conform to the ISO standard method. The experimental technique is
simple and fast, which allows to investigate laser beams under conditions
inaccessible to other methods.Comment: 8 pages, 4 figures, published in Optics Expres
Axel: A Minimalist Tethered Rover for Exploration of Extreme Planetary Terrains
Recent scientific findings suggest that some of the most interesting sites for future exploration of planetary surfaces lie in terrains that are currently inaccessible to conventional robotic rovers. To provide robust and flexible access to these terrains, we have been developing Axel, the robotic rover. Axel is a lightweight two-wheeled vehicle that can access steep terrains and negotiate relatively large obstacles because of its actively managed tether and novel wheel design. This article reviews the Axel system and focuses on those system components that affect Axel's steep terrain mobility. Experimental demonstrations of Axel on sloped and rocky terrains are presented
Chemical mechanical polishing of thin film diamond
The demonstration that Nanocrystalline Diamond (NCD) can retain the superior
Young's modulus (1,100 GPa) of single crystal diamond twinned with its ability
to be grown at low temperatures (<450 {\deg}C) has driven a revival into the
growth and applications of NCD thin films. However, owing to the competitive
growth of crystals the resulting film has a roughness that evolves with film
thickness, preventing NCD films from reaching their full potential in devices
where a smooth film is required. To reduce this roughness, films have been
polished using Chemical Mechanical Polishing (CMP). A Logitech Tribo CMP tool
equipped with a polyurethane/polyester polishing cloth and an alkaline
colloidal silica polishing fluid has been used to polish NCD films. The
resulting films have been characterised with Atomic Force Microscopy, Scanning
Electron Microscopy and X-ray Photoelectron Spectroscopy. Root mean square
roughness values have been reduced from 18.3 nm to 1.7 nm over 25 {\mu}m,
with roughness values as low as 0.42 nm over ~ 0.25 {\mu}m. A polishing
mechanism of wet oxidation of the surface, attachment of silica particles and
subsequent shearing away of carbon has also been proposed.Comment: 6 pages, 6 figure
Recent advances in multidimensional ultrafast spectroscopy
Multidimensional ultrafast spectroscopies are one of the premier tools to investigate condensed phase dynamics of biological, chemical and functional nanomaterial systems. As they reach maturity, the variety of frequency domains that can be explored has vastly increased, with experimental techniques capable of correlating excitation and emission frequencies from the terahertz through to the ultraviolet. Some of the most recent innovations also include extreme cross-peak spectroscopies that directly correlate the dynamics of electronic and vibrational states. This review article summarizes the key technological advances that have permitted these recent advances, and the insights gained from new multidimensional spectroscopic probes.</jats:p
Analysis of the Magnetic Properties of Nitrogenase FeMo Cofactor by Single-Crystal EPR Spectroscopy
The catalytic center of nitrogenase, the [Mo:7Fe:9S:C]:homocitrate FeMo cofactor, is a S=3/2 system with a rhombic magnetic g tensor. Single-crystal EPR spectroscopy in combination with X-ray diffraction were used to determine the relative orientation of the g tensor with respect to the cluster structure. The protein environment influences the electronic structure of the FeMo cofactor, dictating preferred orientations of possible functional relevance
- …