Potential of replacing pawpaw fruit and leaves with cabbage peels as a natural feedstuff in the diet of Achatina achatina linne (African giant land snail)

An experiment was carried out to assess the growth performance of African Giant Land Snail Achatina achatina Linnie fed with three natural feedstuff; pawpaw fruit, pawpaw leaves and cabbage leaves. A total of 24 growing snails of approximately one year old were used for the study. These were randomly divided into six groups and then allotted into the three experimental diets, arranged in a completely randomised design (CRD) order. Dry matter intakes of feed being served every other days, weight gain and size increase of snails were assessed fortnightly. The results showed that pawpaw leaf is higher in protein than cabbage leaf and pawpaw fruit. However, cabbage leaf contains some essential mineralelements, which are useful in body building than the other two feedstuffs. It also showed that snails fed with cabbage leaves had the highest dry matter intake and weight gain of 14.2 and 18.6 g, respectively.Highest shell length and circumference increase of 0.3 and 0.6 cm were obtained in pawpaw fruit and pawpaw leaf respectively. Although there was no significance difference (p > 0.05) in the weight gain ofsnails fed with pawpaw fruit and cabbage leaves, cabbage leaf seems to be richer in protein and other essential mineral elements than pawpaw fruit. It was therefore concluded that cabbage leaf could serve as a good substitute for pawpaw fruit and leaves, which hitherto were known as the preferred natural feedstuff of snails

Iron Accumulation with Age, Oxidative Stress and Functional Decline

Identification of biological mediators in sarcopenia is pertinent to the development of targeted interventions to alleviate this condition. Iron is recognized as a potent pro-oxidant and a catalyst for the formation of reactive oxygen species in biological systems. It is well accepted that iron accumulates with senescence in several organs, but little is known about iron accumulation in muscle and how it may affect muscle function. In addition, it is unclear if interventions which reduced age-related loss of muscle quality, such as calorie restriction, impact iron accumulation. We investigated non-heme iron concentration, oxidative stress to nucleic acids in gastrocnemius muscle and key indices of sarcopenia (muscle mass and grip strength) in male Fischer 344 X Brown Norway rats fed ad libitum (AL) or a calorie restricted diet (60% of ad libitum food intake starting at 4 months of age) at 8, 18, 29 and 37 months of age. Total non-heme iron levels in the gastrocnemius muscle of AL rats increased progressively with age. Between 29 and 37 months of age, the non-heme iron concentration increased by approximately 200% in AL-fed rats. Most importantly, the levels of oxidized RNA in gastrocnemius muscle of AL rats were significantly increased as well. The striking age-associated increase in non-heme iron and oxidized RNA levels and decrease in sarcopenia indices were all attenuated in the calorie restriction (CR) rats. These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects

Controlling the US health care system with policy wedges

State space, Counterfactual history, Health care crisis, Policy wedges,