Recent advances in understanding adverse effects associated with drugs targeting the serotonin receptor, 5-HT GPCR

It has been acknowledged that more women suffer from adverse effects of drugs than men globally. A group of drugs targeting serotonin [5-hydroxytryptamine] (5-HT) binding G-protein-coupled receptors (GPCRs) have been reported to preferentially affect women more than men, causing adverse effects such as breast cancer and infertility. 5-HT GPCR-targeted drugs in the central nervous system (CNS) manage psychiatric conditions, such as depression or bipolar and in the peripheral nervous system (PNS) treat migraines. Physiological characteristics such as specific types of hormones, higher body fat density and smaller body mass in women result in disparities in pharmacodynamics of drugs, thus explaining sex-related differences in the observed adverse effects. In this review, we discuss the side effects of drugs targeting 5-HT GPCRs based on serotonin's roles in the CNS and PNS. We have systematically reviewed adverse effects of drugs targeting 5-HT GPCR using information from the Food and Drug Administration and European Medicines Agency. Further information on drug side effects and receptor targets was acquired from the SIDER and DrugBank databases, respectively. These drugs bind to 5-HT GPCRs in the CNS, namely the brain, and PNS such as breasts, ovaries and testes, potentially causing side effects within these areas. Oestrogen affects both the biosynthesis of 5-HT and the densities of 5-HT GPCRs in given tissues and cells. 5-HT GPCR-targeting drugs perturb this process. This is likely a reason why women are experiencing more adverse effects than men due to their periodic increase and the relatively high concentrations of oestrogen in women and, thus a greater incidence of the oestrogen-mediated 5-HT system interference. In addition, women have a lower concentration of serotonin relative to men and also have a relatively faster rate of serotonin metabolism which might be contributing to the former. We discuss potential approaches that could mitigate at least some of the adverse effects experienced by women taking the 5-HT GPCR-targeting drugs

Seedlings Lacking the PTM Protein Do Not Show a genomes uncoupled (gun) Mutant Phenotype.

The ptm mutant of Arabidopsis does not show a genomes uncoupled mutant phenotype and PTM is therefore unlikely to function in chloroplast-to-nucleus signaling as previously reported

Resuming On-site Services: Final Report and Recommendations of the CUNY Libraries COVID-19 Task Force

This report was prepared by the CUNY Libraries COVID-19 Task Force, which formed in May 2020 with the following charge: Authorized by the CUNY Office of Library Services and the Council of Chief Librarians, the task force is charged to survey best practices shared by libraries world-wide and to develop guidelines for CUNY Libraries site management, staff and user safety, circulation and resource sharing, and materials handling as pandemic conditions evolve. A summary of the draft report was submitted by Interim Dean for Library Services Polly Thistlethwaite to CUNY’s Academic & Student Support Task Force on June 23, 2020. The final version was prepared on June 30, 2020 for wider distribution

Resuming On-site Services: Final Report and Recommendations of the CUNY Libraries COVID-19 Task Force (April 2021)

This report was prepared by the CUNY Libraries COVID-19 Task Force, which formed in May 2020 with the following charge: Authorized by the CUNY Office of Library Services and the Council of Chief Librarians, the task force is charged to survey best practices shared by libraries world-wide and to develop guidelines for CUNY Libraries site management, staff and user safety, circulation and resource sharing, and materials handling as pandemic conditions evolve. A summary of the draft report was submitted by Interim Dean for Library Services Polly Thistlethwaite to CUNY’s Academic & Student Support Task Force on June 23, 2020. The final version was prepared on June 30, 2020 for wider distribution. In February 2021, the Council of Chief Librarians charged the task force with updating the report to reflect changes that had happened in the past year. The task force decided to update the Executive Summary only. In April 2021, the task force submitted the final draft of the update

Introduction for Fisheries and Aquatic Biology

Chapter I. Aquatic Environment. Ken FURUYA and Ichiro YASUDA : chapter_1.pdfChapter II. Biology and Ecology of Aqua-Shere. Toyoji KANEKO, Katsumi TSUKAMOTO, Atsushi TSUDA, Yuzuru SUZUKI and Katsufumi SATOH : chapter_2.pdfChapter III. Aquatic Resource and Production. Ichiro AOKI, Kazuo OGAWA, Taku YAMAKAWA and Tomoyoshi YOSHINAGA : chapter_3.pdfChapter IV. Chemistry of Aquatic Organism and Their Utilization. Hiroki ABE, Shugo WATABE, Yoshihiro OCHIAI, Shigeru OKADA, Naoko YOSHIKAWA, Yoshiharu KINOSHITA, Gen KANEKO and Shigeki MATSUNAGA : chapter_4.pdfChapter V. Relation between Aqua-Shere and Human Life. Hisashi KUROKURA, Hirohide MATSUSHIMA, Shingo KUROHAGI, Haruko YAMASHITA, Akinori HINO, Kazumasa IKUTA, Satoquo SEINO, Masahiko ARIJI, Ken FURUYA, Junichiro OKAMOTO and Nobuyuki YAGI : chapter_5.pdfPart of "Introduction for Fisheries and Aquatic Biology

Molecular interaction of jasmonate and phytochrome A signalling

The phytochrome family of red (R) and far-red (FR) light receptors (phyA–phyE in Arabidopsis) play important roles throughout plant development and regulate elongation growth during de-etiolation and under light. Phytochromes regulate growth through interaction with the phytohormones gibberellin, auxin, and brassinosteroid. Recently it has been established that jasmonic acid (JA), a phytohormone for stress responses, namely wounding and defence, is also important in inhibition of hypocotyl growth regulated by phyA and phyB. This review focuses on recent advances in our understanding of the molecular basis of the interaction between JA and phytochrome signalling particularly during seedling development in Arabidopsis. Significantly, JA biosynthesis genes are induced by phyA. The protein abundance of JAR1/FIN219, an enzyme for the final synthesis step to give JA-Ile, an active form of JA, is also determined by phyA. In addition, JAR1/FIN219 directly interacts with an E3-ligase, COP1, a master regulator for transcription factors regulating hypocotyl growth, suggesting a more direct role in growth regulation. There are a number of points of interaction in the molecular signalling of JA and phytochrome during seedling development in Arabidopsis, and we propose a model for how they work together to regulate hypocotyl growt