41 research outputs found

    Eukaryotic DNA Polymerases: Proposal for a Revised Nomenclature

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    Pol polymeraseIn 1975, a Greek letter nomenclature system was introduced to designate DNA polymerases from mammalian cells (1). Ten years ago, progress in the biochemical analysis of eukaryotic DNA polymerases and in the isolation of their genes, particularly in the yeast Saccharomyces cerevisiae, necessitated a revision of the Greek letter nomenclature system and an expansion to include all eukaryotic organisms (2). Until a few years ago, this system sufficed to designate the six known DNA polymerases α, β, γ, δ, ε, and ζ

    Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

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    Initial crystallographic study of human PCNA in complex with a peptide containing the noncanonical PIP-box sequence of human DNA polymerase ι

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    Crystallization and diffraction studies of a human PCNA–Polι peptide complex are reported

    Crystallographic study of G178S mutant of human proliferating cell nuclear antigen

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    Crystallization and diffraction studies of human PCNA G178S mutant are reported
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