458 research outputs found
Background free CARS imaging by phase sensitive heterodyne CARS
In this article we show that heterodyne CARS, based on a controlled and stable phase-preserving chain, can be used to measure amplitude and phase information of molecular vibration modes. The technique is validated by a comparison of the imaginary part of the heterodyne CARS spectrum to the spontaneous Raman spectrum of polyethylene. The detection of the phase allows for rejection of the non-resonant background from the data. The resulting improvement of the signal to noise ratio is shown by measurements on a sample containing lipid
Shot noise limited heterodyne detection of CARS signals
We demonstrate heterodyne detection of CARS signals using a cascaded phase-preserving chain to generate the\ud
CARS input wavelengths and a coherent local oscillator. The heterodyne ampli¯cation by the local oscillator re-\ud
veals a window for shot noise limited detection before the signal-to-noise is limited by amplitude °uctuations. We\ud
demonstrate an improvement in sensitivity by more than 3 orders of magnitude for detection using a photodiode.\ud
This will enable CARS microscopy to reveal concentrations below the current mMolar range
Expression of receptors for gut peptides in human pancreatic adenocarcinoma and tumour-free pancreas.
Gut hormones that modulate the growth of normal pancreas may also modulate the growth of cancers originating from pancreas. This study visualized and compared the receptors for cholecystokinin (CCK), bombesin (BBS), secretin and vasoactive intestinal peptide (VIP) in tumour-free tissue sections of human pancreas (n = 10) and pancreatic ductal adenocarcinomas (n = 12) with storage phosphor autoradiography using radioligands. CCK-B receptors, present in control pancreata, were not detected in any of the pancreatic cancers. BBS receptors were visualized in control pancreata, but they were absent in 10 of 12 pancreatic cancers. In 5 of 12 pancreatic cancers, receptors for secretin were visualized, while binding for secretin was present in all tumour-free pancreata. Conversely, no specific binding of VIP was detected in control pancreata but was identified in 3 of 12 pancreatic cancer specimens. It is concluded that the expression of gut peptide receptors in pancreatic cancer differs from that in tumour-free pancreas. Receptors for these peptides are present in only a minority of pancreatic cancer specimens
Modeling of mode-locking in a laser with spatially separate gain media
We present a novel laser mode-locking scheme and discuss its unusual
properties and feasibility using a theoretical model. A large set of
single-frequency continuous-wave lasers oscillate by amplification in spatially
separated gain media. They are mutually phase-locked by nonlinear feedback from
a common saturable absorber. As a result, ultra short pulses are generated. The
new scheme offers three significant benefits: the light that is amplified in
each medium is continuous wave, thereby avoiding issues related to group
velocity dispersion and nonlinear effects that can perturb the pulse shape. The
set of frequencies on which the laser oscillates, and therefore the pulse
repetition rate, is controlled by the geometry of resonator-internal optical
elements, not by the cavity length. Finally, the bandwidth of the laser can be
controlled by switching gain modules on and off. This scheme offers a route to
mode-locked lasers with high average output power, repetition rates that can be
scaled into the THz range, and a bandwidth that can be dynamically controlled.
The approach is particularly suited for implementation using semiconductor
diode laser arrays.Comment: 13 pages, 5 figures, submitted to Optics Expres
25 kHz narrow spectral bandwidth of a wavelength tunable diode laser with a short waveguide-based external cavity
We report on the spectral properties of a diode laser with a tunable external
cavity in integrated optics. Even though the external cavity is short compared
to other small-bandwidth external cavity lasers, the spectral bandwidth of this
tunable laser is as small as 25 kHz (FWHM), at a side-mode suppression ratio
(SMSR) of 50 dB. Our laser is also able to access preset wavelengths in as
little as 200 us and able to tune over the full telecom C-band (1530 nm - 1565
nm).Comment: 8 pages, 7 figure
Shot noise limited heterodyne detection of CARS signals
We demonstrate heterodyne detection of CARS signals using a cascaded phase-preserving chain to generate the CARS input wavelengths and a coherent local oscillator. The heterodyne amplification by the local oscillator reveals a window for shot noise limited detection before the signal-to-noise is limited by amplitude fluctuations. We demonstrate an improvement in sensitivity by more than 3 orders of magnitude for detection using a photodiode. This will enable CARS microscopy to reveal concentrations below the current mMolar range
On the absence of bound-state stabilization through short ultra-intense fields
We address the question of whether atomic bound states begin to stabilize in
the short ultra-intense field limit. We provide a general theory of ionization
probability and investigate its gauge invariance. For a wide range of
potentials we find an upper and lower bound by non-perturbative methods, which
clearly exclude the possibility that the ultra intense field might have a
stabilizing effect on the atom. For short pulses we find almost complete
ionization as the field strength increases.Comment: 34 pages Late
On the Influence of Pulse Shapes on Ionization Probability
We investigate analytical expressions for the upper and lower bounds for the
ionization probability through ultra-intense shortly pulsed laser radiation. We
take several different pulse shapes into account, including in particular those
with a smooth adiabatic turn-on and turn-off. For all situations for which our
bounds are applicable we do not find any evidence for bound-state
stabilization.Comment: 21 pages LateX, 10 figure
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