Study the effect of polyphenols extracted from Iraqi grape seeds on glucose , MDA levels and GST activity in streptozotocin (STZ ) induced diabetic mice.

1-Objective:- Polyphenols are biochemical compounds with antioxidant activity against differences diseases related to Lipid peroxidation such as diabetes mellitus. Polyphenols distributed widely in medical plants, the aim of the study is to extract and analyze some polyphenolic compounds from grape seeds and examine their effects on (STZ) induced diabetic mice. 2-Methods:- In the present study , a group of polyphenols has been extracted from Iraqi grape seeds by ethanol and the extract has been analyzed by using High Performance Liquid Chromatography (HPLC) coupled to ultra violet (UV) detection. Five fractions were eluted from the column : procyanidin B1, gallic acid , quercetin , catechin and epicatechin. The detection was recorded at (280 nm). The reactive action of the above polyphenols on glucose, and malondialdehyde (MDA) levels and glutathione – S – transferase (GST) activity was tested in (30) streptozotocin (STZ) induced diabetic mice which treated with extracted grape seeds polyphenols to examine the antioxidant effect of these compounds . Grape seeds polyphenols action on the above parameters was determined before treatment and after (1 week), ( 2 weeks) and (3 weeks) of treatment with this reactive extract. 3-Results:- The data have shown that glucose levels were increased in (30) diabetic mice (after injection with streptozotocin) compared with control group (

Study the effect of polyphenols extracted from Iraqi grape seeds on glucose , MDA levels and GST activity in streptozotocin (STZ ) induced diabetic mice.

1-Objective:- Polyphenols are biochemical compounds with antioxidant activity against differences diseases related to Lipid peroxidation such as diabetes mellitus. Polyphenols distributed widely in medical plants, the aim of the study is to extract and analyze some polyphenolic compounds from grape seeds and examine their effects on (STZ) induced diabetic mice. 2-Methods:- In the present study , a group of polyphenols has been extracted from Iraqi grape seeds by ethanol and the extract has been analyzed by using High Performance Liquid Chromatography (HPLC) coupled to ultra violet (UV) detection. Five fractions were eluted from the column : procyanidin B1, gallic acid , quercetin , catechin and epicatechin. The detection was recorded at (280 nm). The reactive action of the above polyphenols on glucose, and malondialdehyde (MDA) levels and glutathione – S – transferase (GST) activity was tested in (30) streptozotocin (STZ) induced diabetic mice which treated with extracted grape seeds polyphenols to examine the antioxidant effect of these compounds . Grape seeds polyphenols action on the above parameters was determined before treatment and after (1 week), ( 2 weeks) and (3 weeks) of treatment with this reactive extract. 3-Results:- The data have shown that glucose levels were increased in (30) diabetic mice (after injection with streptozotocin) compared with control group (

An Estimation of the Potential Prevalence of "Syndrome X" amongst Diabetics Using Traditional Markers

In order to estimate the potential prevalence of "Syndrome X" in newly diagnosed cases of insulinoplethoric diabetes mellitus, patients were selected from the emergency (accident) ward, University of Benin Teaching Hospital, Benin City, Nigeria. Both risk factors (plasma lipids) and allied metabolic aberration (plasma glucose and creatinine) were assessed in 100 subjects comprising of 60 patients (30 males, 30 females) within the ages of 35 to 70 years and 40 sex and age matched healthy control subjects. Results showed significant increase in patients mean plasma glucose, tricyglycerol and total cholesterol when compared with the respective mean control values at the 5% probability level, using ANOVA. Their lipoprotein-cholesterol profile also, showed a significant difference (P<0.05). The available evidence suggested that male patients between the ages of 51 and 70 years have the highest percentage (77%) of developing "Syndomre X" (artherogenic diseases), a secondary clinical complication if not properly managed. @ JASE

An Estimation of the Potential Prevalence of "Syndrome X" amongst Diabetics Using Traditional Markers

In order to estimate the potential prevalence of "Syndrome X" in newly diagnosed cases of insulinoplethoric diabetes mellitus, patients were selected from the emergency (accident) ward, University of Benin Teaching Hospital, Benin City, Nigeria. Both risk factors (plasma lipids) and allied metabolic aberration (plasma glucose and creatinine) were assessed in 100 subjects comprising of 60 patients (30 males, 30 females) within the ages of 35 to 70 years and 40 sex and age matched healthy control subjects. Results showed significant increase in patients mean plasma glucose, tricyglycerol and total cholesterol when compared with the respective mean control values at the 5% probability level, using ANOVA. Their lipoprotein-cholesterol profile also, showed a significant difference (