The minimal B-L model naturally realized at TeV scale

In a previous paper, we have proposed the minimal B-L extended standard model as a phenomenologically viable model that realizes the Coleman-Weinberg-type breaking of the electroweak symmetry. Assuming the classical conformal invariance and stability up to the Planck scale, we will show in this paper that the model naturally predicts TeV scale B-L breaking as well as a light standard-model singlet Higgs boson and light right-handed neutrinos around the same energy scale. We also study phenomenology and detectability of the model at the Large Hadron Collider (LHC) and the International Linear Collider (ILC).Comment: 24pages, 8figure

大うつ病の診断および治療におけるSLC6A4遺伝子のメチル化解析の有用性

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora

Effects of formulation and processing parameters on sodium availability in a model lipoproteic emulsion gel

Sodium reduction in processed foods is a high priority in the food industry due to the health implications of excessive dietary sodium consumption. Foods with a lipid/protein-based (lipoproteic) emulsion structure (such as processed cheeses and meats) are of particular interest because of their contribution to dietary sodium and the role of sodium in desired sensory and textural properties. When reducing sodium content in these food systems, it is crucial to understand the physicochemical and matrix properties contributing to sodium availability and saltiness perception. The overall objective of this study was to characterize chemical and rheological influences on sodium availability in a model lipoproteic emulsion gel. There were three specific aims to accomplish the overall objective. The first aim was to characterize the effects of formulation and processing parameters on sodium ion molecular mobility and binding in the model gel system. The second aim was to characterize how altering formulation and processing parameters affected rheological and structural properties. The third aim was to correlate the measured mobility and rheological properties with sensory perceived saltiness and texture attributes. To accomplish these objectives, model lipoproteic gels formulated with varying protein, fat, and NaCl content and processed with varying homogenization pressure were prepared. Sodium ion molecular activity was characterized with 23Na nuclear magnetic resonance (NMR) spectroscopy. Single quantum (SQ) experiments were used to characterize the mobility of overall sodium in the system, while double quantum filtered (DQF) experiments were used to characterize sodium in a restricted mobility ('bound') state and quantify relative 'bound' sodium. Formulation and processing parameters were found to influence gel structure and sodium matrix-interactions. Increasing protein or fat content reduced sodium mobility, and increasing protein or fat content or homogenization pressure increased the amount of relative 'bound' sodium. Rheological and structural properties were characterized with small deformation oscillatory rheometry and creep compliance/recovery rheometry. Gel mechanical behavior was successfully modeled with a four-component Burgers model, and it was found that increasing protein, fat, or salt content or homogenization pressure resulted in a stronger and more solid protein network structure. The results from the 23Na NMR and rheometry experiments were correlated with sensory taste and texture properties obtained by quantitative descriptive analysis (QDA). Salty taste and syneresis texture correlated positively with sodium mobility and elastic compliance, and correlated negatively with dry matter content, relative 'bound' sodium, and gel firmness. This study found that formulation and homogenization pressure significantly influence sodium behavior and rheology in lipoproteic emulsion gels, which may have significant implications for saltiness perception and sodium reduction. The results suggest that saltiness perception can be influenced by altering sodium availability via modulation of molecular interactions, texture, and sodium release. Future research could explore increasing saltiness perception by introducing species that compete with sodium for binding sites to increase sodium availability

Resonant Leptogenesis in the Minimal B-L Extended Standard Model at TeV

We investigate the resonant leptogenesis scenario in the minimal B-L extended standard model(SM) with the B-L symmetry breaking at the TeV scale. Through detailed analysis of the Boltzmann equations, we show how much the resultant baryon asymmetry via leptogenesis is enhanced or suppressed, depending on the model parameters, in particular, the neutrino Dirac Yukawa couplings and the TeV-scale Majorana masses of heavy degenerate neutrinos. In order to consider a realistic case, we impose a simple ansatz for the model parameters and analyze the neutrino oscillation parameters and the baryon asymmetry via leptogenesis as a function of only a single CP-phase. We find that for a fixed CP-phase all neutrino oscillation data and the observed baryon asymmetry of the present universe can be simultaneously reproduced.Comment: 25 pages, 15 figures, version to be published in Phys. Rev.

A study for 2-D indoor localization using multiple leaky coaxial cables

Indoor localization technology, which can provide the location information of the target object or stochastic things, is becoming essential requirement for many applications and services such as Internet-of-Things (IoT), real-time control in the development of Fifth-generation (5G) technology. Leaky coaxial cable which can be used as antennas is able to detect the location of the user in a simple way due to its potential property. In this paper, we proposes a simple method to improve the localization accuracy of 2-D indoor localization using multiple LCX cables. In addition, we also evaluate the channel capacity loss due to the localization error of the LCX-MIMO using our proposed method

Autonomous Navigation, Guidance and Control of Small Electric Helicopter

In this study, we design an autonomous navigation, guidance and control system for a small electric helicopter. Only small, light-weight, and inaccurate sensors can be used for the control of small helicopters because of the payload limitation. To overcome the problem of inaccurate sensors, a composite navigation system is designed. The designed navigation system enables us to precisely obtain the position and velocity of the helicopter. A guidance and control system is designed for stabilizing the helicopter at an arbitrary point in three-dimensional space. In particular, a novel and simple guidance system is designed using the combination of optimal control theory and quaternion kinematics. The designs of the study are validated experimentally, and the experimental results verify the efficiency of our navigation, guidance and control system for a small electric helicopter.ArticleINTERNATIONAL JOURNAL OF ADVANCED ROBOTIC SYSTEMS. 10:54 (2013)journal articl

A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b

遺伝病の原因タンパク質が小胞体ストレスを引き起こすメカニズムの解明 --神経変性疾患の新規治療戦略の確立に向けて--. 京都大学プレスリリース. 2022-12-13.A causal relationship between endoplasmic reticulum (ER) stress and the development of neurodegenerative diseases remains controversial. Here, we focused on Seipinopathy, a dominant motor neuron disease, based on the finding that its causal gene product, Seipin, is a protein that spans the ER membrane twice. Gain-of-function mutations of Seipin produce non-glycosylated Seipin (ngSeipin), which was previously shown to induce ER stress and apoptosis at both cell and mouse levels albeit with no clarified mechanism. We found that aggregation-prone ngSeipin dominantly inactivated SERCA2b, the major calcium pump in the ER, and decreased the calcium concentration in the ER, leading to ER stress and apoptosis in human colorectal carcinoma-derived cells (HCT116). This inactivation required oligomerization of ngSeipin and direct interaction of the C-terminus of ngSeipin with SERCA2b, and was observed in Seipin-deficient neuroblastoma (SH-SY5Y) cells expressing ngSeipin at an endogenous protein level. Our results thus provide a new direction to the controversy noted above