Hot Training Conditions Inhibit Adequate Ad Libitum Recovery Fluid Intake of Runners

International Journal of Exercise Science 12(6): 1322-1333, 2019. This study examined voluntary fluid intake, hydration descriptors, and sweat loss estimation accuracy following runs in wet bulb globe temperatures of 18 (TEMP) and 26 ºC (HOT). Twelve male runners completed 1-h runs at 65% of VO2 max with access to water during runs and a variety of beverages for the following 24-h. Urine specific gravity (USG), body mass, fluid intake, and urine output were assessed at 12 and 24-h. Runners lost 1.355 ± 0.263 and 1.943 ± 0.485 L during TEMP and HOT, respectively. Sweat loss volume was underestimated by approximately one-third during both conditions. Cumulative fluid intake from start until 1-h post-run was greater in HOT, but not at 12-h (2.202±0.600 vs 2.265±0.673 L) or 24-h (3.602±0.807 vs 3.742±1.205 L). Runners replaced a lower percentage of sweat losses and displayed higher USG (p \u3c 0.001) for HOT (119±34%; 1.027±0.004) versus TEMP (166±51%; 1.018±0.004) at 12-h while exhibiting repeatable rehydration patterns within runners (ICC = 0.89) between trials. Absolute body mass was unable to differentiate the substantial differences in fluid replacement percentage. Seven runners replace

Challenges in Medicine: The Odyssey of a Patient with Isolated IgG4-Related Eosinophilic Angiocentric Fibrosis Presenting as a Locally Destructive Sinonasal Mass

Eosinophilic angiocentric fibrosis (EAF) is an exceeding rare clinical entity and is considered a part of the spectrum of IgG4-related disease (IgG4RD). We hereby present such an unusual case of a 60-year-old female who presented to us with recurrent sinonasal mass, after a decade long haul of multiple clinical evaluations, biopsies, and debulking surgery without a definitive diagnosis. Over this period, the mass eroded through the ethmoid cells along with nasal septal destruction leading to saddle nose deformity, extended superiorly through the cribriform plates to right frontal lobe, and compressed the optic nerve leading to visual loss. Although initial biopsy was negative, repeat biopsy was performed owing to high clinical suspicion due to all the classic histopathological findings compatible with the diagnosis of eosinophilic angiocentric fibrosis IgG4-related disease (EAF-IgG4RD). Steroids are the recommended first-line therapy; however, our case was resistant to steroids needing rituximab to halt the disease progression. Our case interestingly also had T-cell clonality and isolated isocitrate dehydrogenase 2 enzyme mutation on next-generation sequencing, suggesting a possible role of novel molecular-targeted therapies in this rare disease. This case highlights the clinical challenges physicians face towards diagnosing and treating EAF-IgG4RD, emphasizing the need for high clinical suspicion and the possible role of targeted therapies for this rare disease

Disparities in Prostate Cancer Survival in Appalachian Kentucky: A Population-Based Study

Introduction: Prostate cancer (PC) is the most common male cancer in the USA. When comparing the incidence and mortality rates of PC, the Surveillance Epidemiology and End Results data of 2005–2014 show that Appalachian Kentucky had a lower incidence (113/100 000 v 137/100 000) but a higher mortality rate (23.8% v 21.8%) when compared to non-Appalachian Kentucky. The aim of this study was to further characterize the survival disparities of PC between Appalachian and non-Appalachian Kentucky. Methods: All stages of PC patients diagnosed between 2007 and 2011 were collected through the Kentucky Cancer Registry. Baseline characteristics and survival outcomes were compared between Appalachian Kentucky and non-Appalachian Kentucky, using Pearson χ2 and Cox regression analyses in this population-based analysis. Results: Of 12 871 patients studied, 3482 (26.8%) were from Appalachian Kentucky whereas 8489 (73.2%) were from non-Appalachian Kentucky. Caucasians predominated in both groups. Most Appalachian Kentucky patients were aged 65–74 years. Appalachian Kentucky patients had a higher Gleason score, higher prostate specific antigen (PSA), more aggressive histologic grade, more distant disease, higher comorbidity score, lower education, and higher poverty compared to patients from non-Appalachian Kentucky. There was a 5-year survival difference between Appalachian Kentucky and non-Appalachian Kentucky in unadjusted analysis (p \u3c 0.001) that disappeared after adjusting with Cox regression analysis (p = 0.4). However, worsened survival was still seen with higher Gleason score, higher PSA, distant stage disease, higher Charlson comorbidity index, and very low high school education (p \u3c 0.001). Conclusion: In this population-based analysis, this study shows a significant difference in PC survival between Appalachian and non-Appalachian Kentucky. The difference was not related to geographic location, but rather to high comorbidity score, high poverty rate, and low education. Additional research is needed to understand the healthcare restraints for Appalachian Kentucky

Biola Hour Highlights, 1976 - 01

Essentials of Prayer by Al Sanders Titles of the Savior by Richard Chase Historic Reality and Prophetic Promise by Charles Feinberg Celebrating \u27Xmas\u27 by Samuel Sutherland A Unique Christmas by Glenn O\u27Neal Christmas Comparisons from John 12 by Ron Hafer Mary, the Mother of Jesus by Ernie Peirson My Peace I Give to You by Curtis Mitchell Mary by Lloyd Anderson Revelation by Lloyd Anderson Panel Discussion by Richard Chase, Charles Feinberg, and Samuel Sutherlandhttps://digitalcommons.biola.edu/bhhs/1023/thumbnail.jp

Biola Hour Highlights, 1976 - 01

Essentials of Prayer by Al Sanders Titles of the Savior by Richard Chase Historic Reality and Prophetic Promise by Charles Feinberg Celebrating \u27Xmas\u27 by Samuel Sutherland A Unique Christmas by Glenn O\u27Neal Christmas Comparisons from John 12 by Ron Hafer Mary, the Mother of Jesus by Ernie Peirson My Peace I Give to You by Curtis Mitchell Mary by Lloyd Anderson Revelation by Lloyd Anderson Panel Discussion by Richard Chase, Charles Feinberg, and Samuel Sutherlandhttps://digitalcommons.biola.edu/bhhs/1023/thumbnail.jp

Biola Hour Highlights, 1976 - 12

Daniel by Lloyd Anderson I Thessalonians by Lehman Strauss II Thessalonians by Lehman Strauss Faithfulness of God by Lehman Strauss Psalm 131 by Al Sanders Panel Discussion by Richard Chase, Charles Feinberg, and Samuel Sutherlandhttps://digitalcommons.biola.edu/bhhs/1034/thumbnail.jp

A Targeted Conservation Approach for Improving Environmental Quality: Multiple Benefits and Expanded Opportunities

Find out how targeted conservation practices can have the most impact on environmental quality while causing only a small change in overall agricultural production. Environmental benefits are discussed related to clean air and water, productive soils, diverse wildlife and plant habitat, and biological controls for crop protection.https://lib.dr.iastate.edu/extension_ag_pubs/1084/thumbnail.jp