Accurate and efficient waveforms for compact binaries on eccentric orbits

Compact binaries that emit gravitational waves in the sensitivity band of ground-based detectors can have non-negligible eccentricities just prior to merger, depending on the formation scenario. We develop a purely analytic, frequency-domain model for gravitational waves emitted by compact binaries on orbits with small eccentricity, which reduces to the quasi-circular post-Newtonian approximant TaylorF2 at zero eccentricity and to the post-circular approximation of Yunes et al. (2009) at small eccentricity. Our model uses a spectral approximation to the (post-Newtonian) Kepler problem to model the orbital phase as a function of frequency, accounting for eccentricity effects up to ${\cal{O}}(e^8)$ at each post-Newtonian order. Our approach accurately reproduces an alternative time-domain eccentric waveform model for eccentricities $e\in [0, 0.4]$ and binaries with total mass less than 12 solar masses. As an application, we evaluate the signal amplitude that eccentric binaries produce in different networks of existing and forthcoming gravitational waves detectors. Assuming a population of eccentric systems containing black holes and neutron stars that is uniformly distributed in co-moving volume, we estimate that second generation detectors like Advanced LIGO could detect approximately 0.1-10 events per year out to redshift $z\sim 0.2$, while an array of Einstein Telescope detectors could detect hundreds of events per year to redshift $z \sim 2.3$.Comment: 12 pages, 6 figures, 1 appendix. Submitted to Phys. Rev. D. v2: affiliations updated, one reference corrected. Accepted to Phys. Rev.

Double Compact Objects III: Gravitational Wave Detection Rates

The unprecedented range of second-generation gravitational-wave (GW) observatories calls for refining the predictions of potential sources and detection rates. The coalescence of double compact objects (DCOs)---i.e., neutron star-neutron star (NS-NS), black hole-neutron star (BH-NS), and black hole-black hole (BH-BH) binary systems---is the most promising source of GWs for these detectors. We compute detection rates of coalescing DCOs in second-generation GW detectors using the latest models for their cosmological evolution, and implementing inspiral-merger-ringdown (IMR) gravitational waveform models in our signal-to-noise ratio calculations. We find that: (1) the inclusion of the merger/ringdown portion of the signal does not significantly affect rates for NS-NS and BH-NS systems, but it boosts rates by a factor $\sim 1.5$ for BH-BH systems; (2) in almost all of our models BH-BH systems yield by far the largest rates, followed by NS-NS and BH-NS systems, respectively, and (3) a majority of the detectable BH-BH systems were formed in the early Universe in low-metallicity environments. We make predictions for the distributions of detected binaries and discuss what the first GW detections will teach us about the astrophysics underlying binary formation and evolution.Comment: published in ApJ, 19 pages, 11 figure

Proceedings of the 24th annual Central Plains irrigation conference

Presented at Proceedings of the 24th annual Central Plains irrigation conference held on February 21-22 in Colby, Kansas.Includes bibliographical references

Black hole - neutron star mergers: the first mass gap and kilonovae

Observations of X-ray binaries indicate a dearth of compact objects in the mass range from $\sim 2-5$ $M_{\odot}$ and the existence of this (first mass) gap has been used to advance our understanding of the engines behind core-collapse supernovae. LIGO/Virgo observations provide an independent measure of binary compact remnant masses and several candidate first mass gap objects (either NS or BH) were observed in the O3 science run. We study the formation of BH-NS mergers in the framework of isolated classical binary evolution. We use population synthesis method to evolve binary stars (Population I and II) across cosmic time. The predicted BH-NS mergers from the isolated classical binary evolution are sufficiently abundant ($\sim 0.4-10$ $Gpc^{-3} yr^{-1}$) in the local Universe ($z\approx0$) to produce the observed LIGO/Virgo candidates. We present results on the NS to BH mass ratios ($q=M_{\rm NS}/M_{\rm BH}$ ) in merging systems, showing that although systems with a mass ratio as low as $q=0.02$ can exist, only a small fraction ($\sim 0.05\%-5\%$) of LIGO/Virgo detectable BH-NS mergers have mass ratios below $q=0.05$. We find that with appropriate constraints on the (delayed) supernova engine $\sim 30-40\%$ of LIGO/Virgo BH-NS mergers may host at least one compact object in the gap. The uncertainties in the processes behind compact object formation imply that the fraction of BH-NS systems ejecting mass during the merger is $\sim 0-9\%$. In our reference we find that only $\sim 0.2\%$ of BH-NS mergers will have any mass ejection, and about the same percentage would produce kilonova bright enough to have a chance to be detected even with a large (Subaru-class) $8$m telescope. Interestingly, all these mergers will have both BH and NS in the first mass gap.Comment: 14 pages, 12 figure

Distinguishing black-hole spin-orbit resonances by their gravitational wave signatures. II. Full parameter estimation

Gravitational waves from coalescing binary black holes encode the evolution of their spins prior to merger. In the post-Newtonian regime and on the precession time scale, this evolution has one of three morphologies, with the spins either librating around one of two fixed points ("resonances") or circulating freely. In this paper we perform full parameter estimation on resonant binaries with fixed masses and spin magnitudes, changing three parameters: a conserved "projected effective spin" ξ and resonant family ΔΦ=0,π (which uniquely label the source); the inclination θJN of the binary's total angular momentum with respect to the line of sight (which determines the strength of precessional effects in the waveform); and the signal amplitude. We demonstrate that resonances can be distinguished for a wide range of binaries, except for highly symmetric configurations where precessional effects are suppressed. Motivated by new insight into double-spin evolution, we introduce new variables to characterize precessing black hole binaries which naturally reflects the time scale separation of the system and therefore better encode the dynamical information carried by gravitational waves.D.T. is partially supported by the National Science Foundation through awards PHY-1067985, PHY-1404139, PHY-1055103 and PHY-1307020. D.T. is grateful for the support and hospitality of V. Kalogera's group and the Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) at Northwestern University, where this project was conceived. D.G. is supported by the UK STFC and the Isaac Newton Studentship of the University of Cambridge. E.B. is supported by NSF CAREER Grant PHY-1055103 and by FCT contract IF/00797/2014/CP1214/CT0012 under the IF2014 Programme. M.K. is supported by Alfred P. Sloan Foundation grant FG-2015-65299. T.B.L. acknowledges NSF award PHY-1307020. U.S. is supported by FP7-PEOPLE-2011-CIG Grant No. 293412, FP7-PEOPLE-2011-IRSES Grant No.295189, H2020-MSCA-RISE-2015 Grant No. StronGrHEP-690904, H2020 ERC Consolidator Grant Agreement No. MaGRaTh-646597, SDSC and TACC through XSEDE Grant No. PHY-090003 by the NSF, Finis Terrae through Grant No. ICTS-CESGA-249, STFC Roller Grant No. ST/L000636/1 and DiRAC's Cosmos Shared Memory system through BIS Grant No. ST/J005673/1 and STFC Grant Nos. ST/H008586/1, ST/K00333X/1. Computational resources were provided by the Northwestern University Grail cluster (CIERA) through NSF MRI award PHY-1126812, by the Atlas cluster at AEI Hannover, supported by the Max Planck Institute and by the Nemo 20 at cluster through NSF-092340

Compact Binary Coalescences in the Band of Ground-based Gravitational-Wave Detectors

As the ground-based gravitational-wave telescopes LIGO, Virgo, and GEO 600 approach the era of first detections, we review the current knowledge of the coalescence rates and the mass and spin distributions of merging neutron-star and black-hole binaries. We emphasize the bi-directional connection between gravitational-wave astronomy and conventional astrophysics. Astrophysical input will make possible informed decisions about optimal detector configurations and search techniques. Meanwhile, rate upper limits, detected merger rates, and the distribution of masses and spins measured by gravitational-wave searches will constrain astrophysical parameters through comparisons with astrophysical models. Future developments necessary to the success of gravitational-wave astronomy are discussed.Comment: Replaced with version accepted by CQG

Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model

<p>Abstract</p> <p>Background</p> <p>Human exposure to nanoparticles (NPs) and environmental bacteria can occur simultaneously. NPs induce inflammatory responses and oxidative stress but may also have immune-suppressive effects, impairing macrophage function and altering epithelial barrier functions. The purpose of this study was to assess the potential pulmonary effects of inhalation and instillation exposure to copper (Cu) NPs using a model of lung inflammation and host defense.</p> <p>Methods</p> <p>We used <it>Klebsiella pneumoniae </it>(<it>K.p.</it>) in a murine lung infection model to determine if pulmonary bacterial clearance is enhanced or impaired by Cu NP exposure. Two different exposure modes were tested: sub-acute inhalation (4 hr/day, 5 d/week for 2 weeks, 3.5 mg/m³) and intratracheal instillation (24 hr post-exposure, 3, 35, and 100 μg/mouse). Pulmonary responses were evaluated by lung histopathology plus measurement of differential cell counts, total protein, lactate dehydrogenase (LDH) activity, and inflammatory cytokines in bronchoalveolar lavage (BAL) fluid.</p> <p>Results</p> <p>Cu NP exposure induced inflammatory responses with increased recruitment of total cells and neutrophils to the lungs as well as increased total protein and LDH activity in BAL fluid. Both inhalation and instillation exposure to Cu NPs significantly decreased the pulmonary clearance of <it>K.p.</it>-exposed mice measured 24 hr after bacterial infection following Cu NP exposure versus sham-exposed mice also challenged with <it>K.p </it>(1.4 × 10⁵bacteria/mouse).</p> <p>Conclusions</p> <p>Cu NP exposure impaired host defense against bacterial lung infections and induced a dose-dependent decrease in bacterial clearance in which even our lowest dose demonstrated significantly lower clearance than observed in sham-exposed mice. Thus, exposure to Cu NPs may increase the risk of pulmonary infection.</p

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice.

In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain associated with mIAS, this review also specifically highlights new research focusing on the study of the molecular basis of pain. The incidence of mIAS varies widely (2-78%). As reported across multiple mTOR inhibitor clinical trials, grade 3/4 toxicity occurs in up to 9% of patients. Managing mTOR-associated oral lesions with topical oral, intralesional, and/or systemic steroids can be beneficial, in contrast to the lack of evidence supporting steroid treatment of oral mucositis caused by high-dose chemotherapy or radiation. However, steroid management is not uniformly efficacious in all patients receiving mTOR inhibitors. Furthermore, technology does not presently exist to permit clinicians to predict a priori which of their patients will develop these lesions. There thus remains a strategic need to define the pathobiology of mIAS, the molecular basis of pain, and risk prediction relative to development of the clinical lesion. This knowledge could lead to novel future interventions designed to more effectively prevent mIAS and improve pain management if clinically significant mIAS lesions develop

T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss

Here we present a mouse model for T-cell targeting of hair follicles, linking the pathogenesis of alopecia to that of depigmentation disorders. Clinically, thymus transplantation has been successfully used to treat T-cell immunodeficiency in congenital athymia, but is associated with autoimmunity. We established a mouse model of thymus transplantation by subcutaneously implanting human thymus tissue into athymic C57BL/6 nude mice. These xenografts supported mouse T-cell development. Surprisingly, we did not detect multiorgan autoimmune disease. However, in all transplanted mice, we noted a striking depigmentation and loss of hair follicles. Transfer of T cells from transplanted nudes to syngeneic black-coated RAG(-/-) recipients caused progressive, persistent coat-hair whitening, which preceded patchy hair loss in depigmented areas. Further transfer experiments revealed that these phenomena could be induced by CD4+ T cells alone. Immunofluorescent analysis suggested that Trp2+ melanocyte-lineage cells were decreased in depigmented hair follicles, and pathogenic T cells upregulated activation markers when exposed to C57BL/6 melanocytes in vitro, suggesting that these T cells are not tolerant to self-melanocyte antigens. Our data raise interesting questions about the mechanisms underlying tissue-specific tolerance to skin antigens