MS

thesisExtended monitoring and treatment modalities for the critically ill patient have contributed significantly to nursing capability, while concurrently imposing increased nursing responsibility. Nurses, as the primary uses of health care technology, need a comprehensive understanding of bioinstrumentation to provide safe, high level nursing care. To date, no empirical demonstration of nurse's knowledge of electrical safety is found in the literature. The purpose of this investigation was to document the level of electrical safety knowledge of a representative sample of Salt Lake City Intensive Care Unit nurses. A research designed questionnaire was utilized to define the sample demographics, to test the level of electrical safety knowledge and to elicit the relationship of pertinent background variables with the percentage of correct answers in the electrical safety questionnaire. Statistically, significant relationships were found between: age with the percentage of correct answers in the electrical safety questionnaire, sex with percentage of correct responses in the electrical safety questionnaire and number of years as a Registered Nurse with percentage of accurate answers in the electrical safety questionnaire. Descriptive statistical evaluation revealed that 63% of the sample answered less than 70% of the electrical safety questionnaire accurately. This information led to the conclusion that this sample demonstrated an inadequate nursing knowledge that precludes the nurse's ability to recognize electrical hazards as actual electrical accidents

The separation of recombinant proteins by metal-chelating magnetic affinity supports

The introduction of selective protein adsorption early in the downstream process has the potential to reduce the overall number of steps and increase efficiency and yield. However, the conventional format of a packed column of porous adsorbent is unsuitable for processing particulate containing feed streams as the matrix becomes clogged with trapped solids. There is evidence that non-porous supports are less prone to fouling and are easier to clean (Munro et al. 1977; Hailing and Dunnill, 1979) and are therefore potentially more useful in protein purification from fouling feedstreams. This work describes the preparation, characterisation and use of non-porous magnetic metal chelator adsorbents for the selective recovery of native (haem protein family) and recombinant metal-binding proteins from crude liquors. Non-porous, micron-sized (0.5-1.5 μm), magnetic iron oxide particles were functionalised with metal chelating iminodiacetic acid (IDA) ligands to produce a high capacity pseudoaffinity support. In magnetic affinity adsorption the covalently bound chelating ligand binds to its target protein in solution and the resulting complex is removed from suspension by the application of a magnetic field. The interaction is carried out in free solution and introduction at the start of the purification process renders pre-treatment steps such as clarification and concentration unnecessary and in doing so reduces costs and increases yield. The coating and derivatisation methods resulted in supports with a high level of substitution and low non-specific binding while retaining a high effective surface area for target protein capture (~ 100 m2/g). Supports were optimised with respect to ligand density (60 μmoles Cu2+/g), specific protein binding capacity (200 mg/g), and absence of nonspecific binding. Selectivity and interaction strength of magnetic chelator particles were assessed using a set of native proteins with known behaviour towards immobilised metal chelates. A recombinant bacteriophage T4 lysozyme carrying a polyhistidine tail at its C-terminus was purified in a single step to 94% purity from crude E. coli cell extract using IDA-Cu2+ magnetic chelator supports. By comparison, single step purification by Cu2+-charged IDA agarose supports achieved only 81% purity. Magnetic separation resulted in an overall yield of 82% which corresponded to a purification factor of 4.5

Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner

long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Se

Perceptions of School-Based Telehealth in a Rural State: Moving Forward After COVID-19

  The purpose of this study was to discern the barriers faced by school-based clinicians, chiefly occupational therapists (OTs) and speech-language pathologists (SLPs) who provided telehealth in a primarily rural state during an unexpected declaration of a state of emergency in response to the COVID-19 pandemic. Survey results found the major barriers to implementation of telehealth services to be lack of practitioner training, a lack of access to technology for students, and concerns that the quality of intervention might not be equivalent to in-person service delivery. This article discusses both the benefits and barriers to providing telehealth services in school-based practice and offers considerations for future studies on this topic

Life-span changes to adults' language: Effects of memory and genre

Three different language samples were collected from a group of young adults, 18 to 28 years of age, and a group of elderly adults, 60 to 92 years of age: an oral questionnaire eliciting information about the adults' background, education, and current health and activities; an oral statement describing the person they most admired; and a written statement recounting the most significant event in their lives. In addition, the WAIS vocabulary and digit-span tests were administered to the adults. Age-related changes in the length, clause structure, and fluency of the adults' oral answers and oral and written statements were investigated. There was an overall decrement in the complexity of adults' oral and written statements attributable to an age-related loss of left-branching clauses which occurred in all three language samples. Correlations between the length, clause, and fluency measures from the language samples and the education, health, and WAIS vocabulary and digit-span tests revealed that better-educated adults scored higher on the WAIS vocabulary test, produced longer utterances, and used more right-branching clauses, and that adults with greater memory capacity, as measured by the WAIS Digits Backward test, produced more complex utterances and used more right- and left-branching clauses. Judges found the statements from the elderly adults to be more interesting and clearer than those from the young adults. This finding suggests that there is a trade-off between producing complex syntactic structures and producing clear and interesting prose

Referrals into services for offenders with intellectual disabilities: variables predicting community or secure provision

Background There is a need for research to promote an understanding among service developers on why people with intellectual disabilities (ID) are referred to offender services in order for them to receive appropriate assessment and treatment. Previous studies investigating referrals into forensic ID services have concentrated on referral sources and administrative variables such as legal status. Aims To construct a predictive model for choice of service referral based on a comprehensive range of information about the clientele. Method We conducted a case record study of 336 people referred to community services and 141 to secure provision. We gathered information on referral source, demographics, diagnosis, index behaviour, prior problem behaviours and history of abuse. Results Comparisons revealed 19 candidate variables which were then entered into multivariate logistic regression. The resulting model retained six variables: community living at time of referral, physical aggression, being charged, referral from tertiary health care, diverse problem behaviour and IQ < 50, which correctly predicted the referral pathway for 85.7% of cases. Conclusions An index act of physical aggression and a history of diversity of problem behaviours as predictors against the likelihood of community service referral suggest that professionals have similar concerns about people with ID as they do about their more average offending peers; however, the more severe levels of ID mitigated in favour of community referral, regardless. Offenders with ID tend to be referred within levels of service rather than between them, for example, form tertiary services into generic community services

Contributions of Child’s Physiology and Maternal Behavior to Children’s Trajectories of Temperamental Reactivity

Trajectories of children’s temperamental reactivity (negative affectivity and surgency) were examined in a community sample of 370 children across the ages of 4 to 7 using Hierarchical Linear Modeling. Children’s physiological reactivity (respiratory sinus arrhythmia, RSA), physiological regulation (?RSA), and maternal parenting behavior were included as predictors of children’s trajectories of temperamental reactivity. Results indicated that negative affectivity and surgency decreased from 4 to 7 years of age, however within-person changes in negative affectivity were dependent on levels of baseline RSA and not age. Increases in negative affectivity were also predicted by higher levels of earlier maternal controlling behavior. Decreases in surgency were predicted by higher levels of ?RSA during mother-child interaction tasks and positive parenting behavior. Baseline RSA and maternal controlling parenting also accounted for interindividual differences in children’s negative affectivity at age 7, while gender and children’s baseline RSA accounted for interindividual differences in children’s surgency at age 7. Overall, these results provide further evidence that parenting behavior and children’s RSA influence the changes that occur in children’s temperamental reactivity

Parental ADHD Symptomology and Ineffective Parenting: The Connecting Link of Home Chaos

Objective. This study examines links between maternal and paternal attention-deficit/hyperactivity disorder (ADHD) symptoms and parenting practices that require inhibition of impulses, sustained attention, and consistency; the role of home chaos in these associations is also assessed. Design. ADHD symptoms, the level of home chaos, and parenting practices (e.g., involvement, inconsistent discipline, supportive and nonsupportive responses to children’s negative emotions, and positive parenting) were assessed through self-reports of 311 mothers and 149 fathers of middle-childhood children. Teachers assessed the child ADHD symptoms. Results. Mothers reported higher home chaos when they or their children had higher levels of ADHD symptoms; for fathers, only their own ADHD symptoms predicted higher levels of home chaos. Mothers’ ADHD symptoms were positively associated with inconsistent discipline and nonsupportive responses to children’s negative emotions, and these associations were mediated by home chaos. Higher levels of fathers’ ADHD symptoms predicted more inconsistent discipline, low involvement, and a low level of supportive and a high level of nonsupportive responses to children’s negative emotions. Home chaos moderated the link between paternal ADHD and inconsistent discipline and mediated the link between paternal ADHD and involvement. Overall, positive aspects of parenting, and those that require attention and ability to control one’s impulses, may be compromised in fathers with high levels of ADHD symptoms. Conclusions. Effectiveness of specific parenting practices for both mothers and fathers may be compromised in parents with ADHD symptoms. In certain cases, parental ADHD symptoms translate into ineffective parenting through disorganized homes