Alkaloidszármazékok szintézise = Synthesis of alkaloid derivatives

a) Elsőként alkalmaztunk 3-nitrokromén-származékokat 2 pi komponensként azometin-ilidek 1,3-dipoláris cikloaddíciójában b) Új, egyedényes eljárást dolgoztunk ki hexahidro-pirrolo[2,1-a]izokinolinok előállítására c) Új azepin gyűrűt tartalmozó indolszármazékok előállítását valósítottuk meg 1,7-elektrociklizációs reakciók segítségével d) A lamellarin alkaloidok gyűrűrendszerének egyszerű szintézisét valósítottuk meg a pirrolo[2,1-a]izokinolin gyűrűrendszer 1,5-dipoláris ciklizációs úton történő előállításával, valamint egy független 1,3-dipoláris cikloaddíciót felhasználó szintézisúton. e) Új -karbolin-származékokat állítottunk elő azometin-ilidek 1,7-elektrociklizációjával f) 6,7-Dimetoxi-3,4-dihidroizokinolinok és a 3,4-dihidro-ß-karbolinok új reakcióit fedeztük fel dipolarofilekkel g) Új kinolin-származékokat állítottunk elő azometin-ilidek 1,3-dipoláris cikloaddíciójával h) Ningalin intermedierek szintézisét valósítottuk meg 1,5-elektrociklizációs reakciókban | a ) We have applied 3-nitrochromene derivatives as 2pi components in 1,3-dipolar cycloadditions of azomethine ylides b) We described a novel one-pot, three component access to hexahydro-pyrrolo[2,1-a]isoquinolines by an alkylation - dehydrohalogenation - 1,3-dipolar cycloaddition sequence c) New b-carboline derivatives were synthesized via 1,7-electrocyclisation of azomethine ylides d) 1,5-Electrocyclisation of azomethine ylides leading to pyrrolo[2,1-a]isoquinolines - Concise construction of the lamellarine skeleton e) Synthesis of benz[5,6]azepino[4,3-b]indoles by 1,7-electrocyclisation of azomethine ylides f) Novel reactions of 6,7-dimethoxy-3,4-dihydroisoquinoline and 3,4-dihydro-ß-carboline with dipolarophiles g) The synthesis of new functionalized quinolyl derivatives has been described, based on the 1,3-dipolar cycloaddition of azomethine ylides h)The synthesis of Ningalin alkaloid intermediates was accomplished by the 1,5-electrocyclisation of azomethine ylide

Electrocyclization and Unexpected Reactions of Non-Stabilized α,β:γ,δ-Unsaturated Azomethine Ylides: Experimental and Theoretical Studies

This project was supported by National Research, Development and Innovation Fund of Hungary, financed under the (OTKA PD128612) funding scheme. The authors are grateful to the Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/799/21/7), the ÚNKP-21-5 new National Excellence Program, NVKP-16 (1-2016-0043), KFI-16 (1-2016-0177), KFI-18 (00097) and VKE-18 (00032) of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation Fund for financial support

Microglial control of neuronal development via somatic purinergic junctions

Microglia, the resident immune cells of the brain, play important roles during development. Although bi-directional communication between microglia and neuronal progenitors or immature neurons has been demonstrated, the main sites of interaction and the underlying mechanisms remain elusive. By using advanced methods, here we provide evidence that microglial processes form specialized contacts with the cell bodies of developing neurons throughout embryonic, early postnatal, and adult neurogenesis. These early developmental contacts are highly reminiscent of somatic purinergic junctions that are instrumental for microglia-neuron communication in the adult brain. The formation and maintenance of these junctions is regulated by functional microglial P2Y12 receptors, and deletion of P2Y12Rs disturbs proliferation of neuronal precursors and leads to aberrant cortical cytoarchitecture during development and in adulthood. We propose that early developmental formation of somatic purinergic junctions represents an important interface for microglia to monitor the status of immature neurons and control neurodevelopment

Steric and electronic tuning of atropisomeric amino alcohol type ligands with a 1-arylpyrrole backbone

The synthesis of new, trifluoromethyl group containing atropisomeric amino alcohols and their application in enantioselective diethylzinc additions to aldehydes is described. A significant improvement of the enantioinductive effects of the new ligands by increasing the Bronsted acidity and bulkiness of the triarylcarbinol moiety is also reported. Tuning was achieved by the introduction of phenyl substituents containing two trifluoromethyl groups onto the alpha-carbon of the tertiary alcohol part of the ligand. The application of the new catalysts provided 1-(substituted phenyl)propanols with excellent enantiomeric purities. (C) 2015 Elsevier Ltd. All rights reserved

Large-scale ocean circulation in the Southern Hemisphere with closed and open Drake Passage--A laboratory minimal model approach

We report on a laboratory model of the large-scale flow phenomena in the Southern Ocean with a closed Drake Passage, imitating the situation before the Eocene-Oligocene transition (EOT) ca. 34 million years ago. In a differentially heated rotating annular wave tank an insulating ‘meridional’ barrier is installed to block zonal circulation. The obtained temperature fields and time series are compared to the ones from control runs with partially blocked and fully opened ‘passages’. In the ‘closed’ case a persistent azimuthal temperature gradient emerges whose magnitude scales linearly with the ‘meridional’ temperature contrast. The anomalous temperature distribution is accompanied with perturbations of the background flow yielding significantly larger low frequency variability than in the ‘opened’ configuration. The experimental findings have implications to the EOT but at present validation of results is hindered by the lack of deep-sea drilling data from the Southeast Pacific and adjacent parts of the Southern Ocean. Our model may inspire further paleoceanographic research in this largely unexplored region