884 research outputs found
Product rule for gauge invariant Weyl symbols and its application to the semiclassical description of guiding center motion
We derive a product rule for gauge invariant Weyl symbols which provides a
generalization of the well-known Moyal formula to the case of non-vanishing
electromagnetic fields. Applying our result to the guiding center problem we
expand the guiding center Hamiltonian into an asymptotic power series with
respect to both Planck's constant and an adiabaticity parameter already
present in the classical theory. This expansion is used to determine the
influence of quantum mechanical effects on guiding center motion.Comment: 24 pages, RevTeX, no figures; shortened version will be published in
J.Phys.
Bacteremia After Prophylaxis II
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141639/1/jper0371.pd
Template-Directed Synthesis of Mechanically Interlocked Molecular Bundles Using Dynamic Covalent Chemistry
Mixing the dipyrido[24]crown-8 derivatives carrying one or two formyl group(s) on the 4 position(s) of their pyridine ring(s) with a 3-fold symmetrical trisammonium ion template in a 3:1 ratio in CD3NO2 results in the formation of thermodynamically stable [4]pseudorotaxanes which, upon addition of a 1,3,5 trisaminobenzene cap, form mechanically interlocked molecular bundles with one and two caps, respectively, by virtue of dynamic imine bond formation
The KATRIN Pre-Spectrometer at reduced Filter Energy
The KArlsruhe TRItium Neutrino experiment, KATRIN, will determine the mass of
the electron neutrino with a sensitivity of 0.2 eV (90% C.L.) via a measurement
of the beta-spectrum of gaseous tritium near its endpoint of E_0 =18.57 keV. An
ultra-low background of about b = 10 mHz is among the requirements to reach
this sensitivity. In the KATRIN main beam-line two spectrometers of MAC-E
filter type are used in a tandem configuration. This setup, however, produces a
Penning trap which could lead to increased background. We have performed test
measurements showing that the filter energy of the pre-spectrometer can be
reduced by several keV in order to diminish this trap. These measurements were
analyzed with the help of a complex computer simulation, modeling multiple
electron reflections both from the detector and the photoelectric electron
source used in our test setup.Comment: 22 pages, 12 figure
Quantum Charged Spinning Particles in a Strong Magnetic Field (a Quantal Guiding Center Theory)
A quantal guiding center theory allowing to systematically study the
separation of the different time scale behaviours of a quantum charged spinning
particle moving in an external inhomogeneous magnetic filed is presented. A
suitable set of operators adapting to the canonical structure of the problem
and generalizing the kinematical momenta and guiding center operators of a
particle coupled to a homogenous magnetic filed is constructed. The Pauli
Hamiltonian rewrites in this way as a power series in the magnetic length making the problem amenable to a perturbative analysis. The
first two terms of the series are explicitly constructed. The effective
adiabatic dynamics turns to be in coupling with a gauge filed and a scalar
potential. The mechanism producing such magnetic-induced geometric-magnetism is
investigated in some detail.Comment: LaTeX (epsfig macros), 27 pages, 2 figures include
Neurology
Contains research objectives and reports on six research projects.U.S. Public Health Service (B-3055)U.S. Public Health Service (B-3090)Office of Naval Research (Nonr-1841 (70))Air Force (AF33(616)-7588)Air Force (AFAFOSR-155-63)Air Force (AFAFOSR-155-63)Army Chemical Corps (DA-18-108-405-Cml-942)National Science Foundation (Grant G-16526
Origin and Evolution of Saturn's Ring System
The origin and long-term evolution of Saturn's rings is still an unsolved
problem in modern planetary science. In this chapter we review the current
state of our knowledge on this long-standing question for the main rings (A,
Cassini Division, B, C), the F Ring, and the diffuse rings (E and G). During
the Voyager era, models of evolutionary processes affecting the rings on long
time scales (erosion, viscous spreading, accretion, ballistic transport, etc.)
had suggested that Saturn's rings are not older than 100 My. In addition,
Saturn's large system of diffuse rings has been thought to be the result of
material loss from one or more of Saturn's satellites. In the Cassini era, high
spatial and spectral resolution data have allowed progress to be made on some
of these questions. Discoveries such as the ''propellers'' in the A ring, the
shape of ring-embedded moonlets, the clumps in the F Ring, and Enceladus' plume
provide new constraints on evolutionary processes in Saturn's rings. At the
same time, advances in numerical simulations over the last 20 years have opened
the way to realistic models of the rings's fine scale structure, and progress
in our understanding of the formation of the Solar System provides a
better-defined historical context in which to understand ring formation. All
these elements have important implications for the origin and long-term
evolution of Saturn's rings. They strengthen the idea that Saturn's rings are
very dynamical and rapidly evolving, while new arguments suggest that the rings
could be older than previously believed, provided that they are regularly
renewed. Key evolutionary processes, timescales and possible scenarios for the
rings's origin are reviewed in the light of tComment: Chapter 17 of the book ''Saturn After Cassini-Huygens'' Saturn from
Cassini-Huygens, Dougherty, M.K.; Esposito, L.W.; Krimigis, S.M. (Ed.) (2009)
537-57
Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.
Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB inhibitors have been suggested as potential therapeutic drugs for inflammatory diseases. We show here that DTCs inhibited both interleukin 2 (IL-2) synthesis and membrane expression of antigens which are induced during T-cell activation. This inhibition, which occurred with a parallel activation of c-Jun transactivating functions and expression, was reflected by transfection experiments at the IL-2 promoter level, and involved not only the inhibition of NF-kappaB-driven reporter activation but also that of nuclear factor of activated T cells (NFAT). Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1. Furthermore, PDTC differentially targeted both NFATp and NFATc family members, inhibiting the transactivation functions of NFATp and mRNA induction of NFATc. Strikingly, Western blotting and immunocytochemical experiments indicated that PDTC promoted a transient and rapid shuttling of NFATp and NFATc, leading to their accelerated export from the nucleus of activated T cells. We propose that the activation of an NFAT kinase by PDTC could be responsible for the rapid shuttling of the NFAT, therefore transiently converting the sustained transactivation of this transcription factor that occurs during lymphocyte activation, and show that c-Jun NH2-terminal kinase (JNK) can act by directly phosphorylating NFATp. In addition, the combined inhibitory effects on NFAT and NF-KB support a potential use of DTCs as immunosuppressants
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