No One To Bear Witness: Country Information and LGBTQ Asylum Seekers

This article examines the use of country information in determining claims for refugee status based on sexual orientation or gender identity. Limitations to country information remove diverse individual experiences from the “historical record” and obstruct marginalized individuals’ ability to prove their claims for protection. Discrimination and marginalization may be echoed and perpetuated within country information itself, which privileges certain voices over others. MD (same-sex-oriented males: risk) India CG [2014], the United Kingdom’s current “country guidance” decision on claims for protection by same-sex oriented men from India, is examined in light of these themes. Cet article étudie l’utilisation de renseignements sur le pays d’origine afin de déterminer les demandes de statut de réfugié en lien avec l’orientation sexuelle et l’identité de genre. Les limites en matière de renseignements sur le pays d’origine effacent du registre historique diverses expériences individuelles et font obstruction à la capacité qu’ont des personnes marginalisées de justifier leur demande de protection. La discrimination et la marginalisation peuvent être répétées et prorogées par l’information même délivrée par les pays, qui privilégie certaines voix sur d’autres. À la lumière de ces thèmes de réflexion est étudié le document du Upper Tribunal (Royaume-Uni) MD (same-sex oriented males: risk) India CG [2014], qui établit les lignes directrices actuelles de pays en matière de décision concernant les demandes de protection pour les hommes homosexuels provenant d’Inde

Calculating a deprivation index using census data

Background Deprivation indexes have widespread use in academic research and in local and national government applications. It is useful for people to understand their construction and to be able to calculate their own measures. Aims We provide an overview of the background to area based deprivation measures. We detail and explain a series of steps taken to calculate a deprivation index for small areas in Australia. Data and methods We use data from Australia’s 2016 Census of Population and Housing for the SA2 level of geography. After defining the set of variables used as inputs, we emulate the steps taken to calculate other census based deprivation indexes. Results The resulting scheme correlates closely with an official, but more sophisticated deprivation measure, suggesting that simple schemes have utility. Conclusions There are choices to be made for input variables and for some of the detail of the calculations. Researchers can follow the steps we describe to develop their own measures

Exploring ethnic inequalities in health: Evidence from the Health Survey for England, 1998-2011

Issues of social justice and social and spatial inequalities in health have long been researched, yet there is a relative paucity of research on ethnic inequalities in health. Given the increasing ethnic diversity of England's population and the persistence of unjust differences in health this research is timely. We used annual data from the Health Survey for England between 1998 and 2011, combined into a time-series dataset, to examine the influence of socioeconomic and spatial factors on ethnic variations in health and to explore whether inequalities have changed over time. Our analysis reveals that ethnic differences in health are largely rooted in socioeconomic or spatial difference, although variations by health outcome are observed. This work builds on existing literature which looks to socioeconomic and spatial difference for explanations of ethnic inequalities in health, rather than any supposed inherent underlying risk of poor health for minority ethnic groups

Major element and primary sulfur concentrations in Apollo 12 mare basalts: The view from melt inclusions

Major element and sulfur concentrations have been determined in experimentally heated olivine-hosted melt inclusions from a suite of Apollo 12 picritic basalts (samples 12009, 12075, 12020, 12018, 12040, 12035). These lunar basalts are likely to be genetically related by olivine accumulation (Walker et al. 1976a, b). Our results show that major element compositions of melt inclusions from samples 12009, 12075, and 12020 follow model crystallization trends from a parental liquid similar in composition to whole rock sample 12009, thereby partially confirming the olivine accumulation hypothesis. In contrast, the compositions of melt inclusions from samples 12018, 12040, and 12035 fall away from model crystallization trends, suggesting that these samples crystallized from melts coin positionally distinct from the 12009 parent liquid and therefore may not be strictly cogenetic with other members of the Apollo 12 picritic basalt suite. Sulfur concentrations in melt inclusions hosted in early crystallized olivine (17075) are consistent with a primary magmatic composition of 1050 ppm S, or about a factor of 2 greater than whole rock compositions with 400-600 ppm S. The Apollo 12 picritic basalt parental magma apparently experienced outgassing and loss of S during transport and eruption on the lunar surface. Even with the higher estimates of primary magmatic sulfur concentrations provided by the melt inclusions, the Apollo 12 picritic basalt magmas would have been undersaturated in sulfide in their mantle source regions and capable of transporting chalcophile elements from the lunar mantle to the surface. Therefore, the measured low concentration of chalcophile elements (e.g., Cu, Au, PGEs) in these lavas must be a primary feature of the lunar mantle and is not related to residual sulfide remaining in the mantle during melting. We estimate the sulfur concentration of the Apollo 12 mare basalt source regions to be similar to 75 ppm, which is significantly lower than that of the terrestrial mantle

Peptide probes for proteases - innovations and applications for monitoring proteolytic activity.

Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and critiques the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both in vitro and in vivo

Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring

Mucous membrane pemphigoid (MMP) is a systemic mucosal scarring disease, commonly causing blindness, for which there is no antifibrotic therapy. Aldehyde dehydrogenase (ALDH) family 1 is upregulated in both ocular MMP (OMMP) conjunctiva and cultured fibroblasts. Application of the ALDH metabolite, retinoic acid (RA), to normal human conjunctival fibroblasts in vitro induced a diseased phenotype. Conversely, application of ALDH inhibitors, including disulfiram, to OMMP fibroblasts in vitro restored their functionality to that of normal controls. ALDH1 is also upregulated in the mucosa of the mouse model of scarring allergic eye disease, used here as a surrogate for OMMP, in which topical application of disulfiram decreased fibrosis in vivo. These data suggest that progressive scarring in OMMP results from ALDH/RA fibroblast autoregulation, that the ALDH1 subfamily has a central role in immune-mediated ocular mucosal scarring, and that ALDH inhibition with disulfiram is a potential, and readily translatable, antifibrotic therapy

Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro

Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of chronic fibrotic diseases. However, the mechanism by which paracrine effects of CTGF control the cell fate of neighboring epithelial cells is not known. In this study, we investigated the paracrine effects of CTGF overexpressed in fibroblasts of Col1a2-CTGF transgenic mice on epithelial cells of skin and lung. The skin and lungs of Col1a2-CTGF transgenic mice were examined for phenotypic markers of epithelial activation and differentiation and stimulation of signal transduction pathways. In addition to an expansion of the dermal compartment in Col1a2-CTGF transgenic mice, the epidermis was characterized by focal hyperplasia, and basal cells stained positive for aSMA, Snail, S100A4 and Sox9, indicating that these cells had undergone a change in their genetic program. Activation of phosphorylated p38 and phosphorylated Erk1/2 was observed in the granular and cornified layers of the skin. Lung fibrosis was associated with a marked increase in cells coexpressing epithelial and mesenchymal markers in the lesional and unaffected lung tissue of Col1a2-CTGF mice. In epithelial cells treated with TGFb, CTGF-specific siRNA-mediated knockdown suppressed Snail, Sox9, S100A4 protein levels and restored E-cadherin levels. Both adenoviral expression of CTGF in epithelial cells and treatment with recombinant CTGF induced EMT-like morphological changes and expression of a-SMA. Our in vivo and in vitro data supports the notion that CTGF expression in mesenchymal cells in the skin and lungs can cause changes in the differentiation program of adjacent epithelial cells. We speculate that these changes might contribute to fibrogenesis