14,336 research outputs found
Stratospheric circulation studies based on Tiros 7, 15-micron data Final report
Stratospheric temperature distribution data based on Tiros 7 radiometer dat
Kinetic limitations of cooperativity based drug delivery systems
We study theoretically a novel drug delivery system that utilizes the
overexpression of certain proteins in cancerous cells for cell specific
chemotherapy. The system consists of dendrimers conjugated with "keys" (ex:
folic acid) which "key-lock" bind to particular cell membrane proteins (ex:
folate receptor). The increased concentration of "locks" on the surface leads
to a longer residence time for the dendrimer and greater incorporation into the
cell. Cooperative binding of the nanocomplexes leads to an enhancement of cell
specificity. However, both our theory and detailed analysis of in-vitro
experiments indicate that the degree of cooperativity is kinetically limited.
We demonstrate that cooperativity and hence the specificity to particular cell
type can be increased by making the strength of individual bonds weaker, and
suggest a particular implementation of this idea. The implications of the work
for optimizing the design of drug delivery vehicles are discussed.Comment: 4 pages, 4 figures, v3: minor revision
Far field imaging by a planar lens: diffraction versus superresolution
We resolve the long standing controversy regarding the imaging by a planar
lens made of left-handed media and demonstrate theoretically that its far field
image has a fundamentally different origin depending on the relationship
between losses {inside} the lens and the wavelength of the light . At
small enough the image is always governed by diffraction theory, and
the resolution is independent of the absorption if both Im and
Im. For any finite , however, a critical absorption exists
below which the superresolution regime takes place, though this absorption is
extremely low and can hardly be achieved. We demonstrate that the transition
between diffraction limited and superresolution regimes is governed by {the}
universal parameter combining absorption, wavelength, and lens thickness.
Finally, we show that this parameter is related to the resonant excitation of
the surface plasma waves
Spatio-Temporal Patterning in Primary Motor Cortex at Movement Onset
Voluntary movement initiation involves the engagement of large populations of motor cortical neurons around movement onset. Despite knowledge of the temporal dynamics that lead to movement, the spatial structure of these dynamics across the cortical surface remains unknown. In data from 4 rhesus macaques, we show that the timing of attenuation of beta frequency local field potential oscillations, a correlate of locally activated cortex, forms a spatial gradient across primary motor cortex (MI). We show that these spatio-temporal dynamics are recapitulated in the engagement order of ensembles of MI neurons. We demonstrate that these patterns are unique to movement onset and suggest that movement initiation requires a precise spatio-temporal sequential activation of neurons in MI
Spreading in Social Systems: Reflections
In this final chapter, we consider the state-of-the-art for spreading in
social systems and discuss the future of the field. As part of this reflection,
we identify a set of key challenges ahead. The challenges include the following
questions: how can we improve the quality, quantity, extent, and accessibility
of datasets? How can we extract more information from limited datasets? How can
we take individual cognition and decision making processes into account? How
can we incorporate other complexity of the real contagion processes? Finally,
how can we translate research into positive real-world impact? In the
following, we provide more context for each of these open questions.Comment: 7 pages, chapter to appear in "Spreading Dynamics in Social Systems";
Eds. Sune Lehmann and Yong-Yeol Ahn, Springer Natur
Reflective Ghost Imaging through Turbulence
Recent work has indicated that ghost imaging may have applications in
standoff sensing. However, most theoretical work has addressed
transmission-based ghost imaging. To be a viable remote-sensing system, the
ghost imager needs to image rough-surfaced targets in reflection through long,
turbulent optical paths. We develop, within a Gaussian-state framework,
expressions for the spatial resolution, image contrast, and signal-to-noise
ratio of such a system. We consider rough-surfaced targets that create fully
developed speckle in their returns, and Kolmogorov-spectrum turbulence that is
uniformly distributed along all propagation paths. We address both classical
and nonclassical optical sources, as well as a computational ghost imager.Comment: 13 pages, 3 figure
Large-scale Spatiotemporal Spike Patterning Consistent with Wave Propagation in Motor Cortex
Aggregate signals in cortex are known to be spatiotemporally organized as propagating waves across the cortical surface, but it remains unclear whether the same is true for spiking activity in individual neurons. Furthermore, the functional interactions between cortical neurons are well documented but their spatial arrangement on the cortical surface has been largely ignored. Here we use a functional network analysis to demonstrate that a subset of motor cortical neurons in non-human primates spatially coordinate their spiking activity in a manner that closely matches wave propagation measured in the beta oscillatory band of the local field potential. We also demonstrate that sequential spiking of pairs of neuron contains task-relevant information that peaks when the neurons are spatially oriented along the wave axis. We hypothesize that the spatial anisotropy of spike patterning may reflect the underlying organization of motor cortex and may be a general property shared by other cortical areas
Avalanche analysis from multi-electrode ensemble recordings in cat, monkey and human cerebral cortex during wakefulness and sleep
Self-organized critical states are found in many natural systems, from
earthquakes to forest fires, they have also been observed in neural systems,
particularly, in neuronal cultures. However, the presence of critical states in
the awake brain remains controversial. Here, we compared avalanche analyses
performed on different in vivo preparations during wakefulness, slow-wave sleep
and REM sleep, using high-density electrode arrays in cat motor cortex (96
electrodes), monkey motor cortex and premotor cortex and human temporal cortex
(96 electrodes) in epileptic patients. In neuronal avalanches defined from
units (up to 160 single units), the size of avalanches never clearly scaled as
power-law, but rather scaled exponentially or displayed intermediate scaling.
We also analyzed the dynamics of local field potentials (LFPs) and in
particular LFP negative peaks (nLFPs) among the different electrodes (up to 96
sites in temporal cortex or up to 128 sites in adjacent motor and pre-motor
cortices). In this case, the avalanches defined from nLFPs displayed power-law
scaling in double log representations, as reported previously in monkey.
However, avalanche defined as positive LFP (pLFP) peaks, which are less
directly related to neuronal firing, also displayed apparent power-law scaling.
Closer examination of this scaling using more reliable cumulative distribution
functions (CDF) and other rigorous statistical measures, did not confirm
power-law scaling. The same pattern was seen for cats, monkey and human, as
well as for different brain states of wakefulness and sleep. We also tested
other alternative distributions. Multiple exponential fitting yielded optimal
fits of the avalanche dynamics with bi-exponential distributions. Collectively,
these results show no clear evidence for power-law scaling or self-organized
critical states in the awake and sleeping brain of mammals, from cat to man.Comment: In press in: Frontiers in Physiology, 2012, special issue "Critical
Brain Dynamics" (Edited by He BY, Daffertshofer A, Boonstra TW); 33 pages, 13
figures. 3 table
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