435 research outputs found
Non-diagonal open spin-1/2 XXZ quantum chains by separation of variables: Complete spectrum and matrix elements of some quasi-local operators
The integrable quantum models, associated to the transfer matrices of the
6-vertex reflection algebra for spin 1/2 representations, are studied in this
paper. In the framework of Sklyanin's quantum separation of variables (SOV), we
provide the complete characterization of the eigenvalues and eigenstates of the
transfer matrix and the proof of the simplicity of the transfer matrix
spectrum. Moreover, we use these integrable quantum models as further key
examples for which to develop a method in the SOV framework to compute matrix
elements of local operators. This method has been introduced first in [1] and
then used also in [2], it is based on the resolution of the quantum inverse
problem (i.e. the reconstruction of all local operators in terms of the quantum
separate variables) plus the computation of the action of separate covectors on
separate vectors. In particular, for these integrable quantum models, which in
the homogeneous limit reproduce the open spin-1/2 XXZ quantum chains with
non-diagonal boundary conditions, we have obtained the SOV-reconstructions for
a class of quasi-local operators and determinant formulae for the
covector-vector actions. As consequence of these findings we provide one
determinant formulae for the matrix elements of this class of reconstructed
quasi-local operators on transfer matrix eigenstates.Comment: 40 pages. Minor modifications in the text and some notations and some
more reference adde
Prevention of coronary microvascular obstruction by addressing ischemia reperfusion injury-part a
Most recently, substantial research efforts were directed to the treatment and prevention of coronary microvascular obstruction (CMVO) by targeting various mechanisms involved in its multifactorial pathophysiology. Among other strategies, antiplatelets and vasodilators were tested in order to reduce thrombus burden and coronary vasospasm potentially resulting in enhanced myocardial perfusion. Furthermore, the impact of intensified statin therapy was evaluated in numerous investigations. Although most of these studies failed to convincingly prove beneficial effects regarding CMVO, especially antiplatelets and statins are indispensable cornerstones of post-infarction medical therapy. This chapter discusses the scientific evidence and guideline recommendations for the use of antiplatelets, statins, and vasodilators in patients with myocardial infarction with a particular focus on their efficacy to treat or prevent CMVO
Form factors of descendant operators in the massive Lee-Yang model
The form factors of the descendant operators in the massive Lee-Yang model
are determined up to level 7. This is first done by exploiting the conserved
quantities of the integrable theory to generate the solutions for the
descendants starting from the lowest non-trivial solutions in each operator
family. We then show that the operator space generated in this way, which is
isomorphic to the conformal one, coincides, level by level, with that implied
by the -matrix through the form factor bootstrap. The solutions we determine
satisfy asymptotic conditions carrying the information about the level that we
conjecture to hold for all the operators of the model.Comment: 23 page
Point-like topological defects in bilayer quantum Hall systems
Following a suggestion given in Phys. Lett. B 571 (2003) 250, we show how a
bilayer Quantum Hall system at fillings nu =m/pm+2 can exhibit a point-like
topological defect in its edge state structure. Indeed our CFT theory for such
a system, the Twisted Model (TM), gives rise in a natural way to such a feature
in the twisted sector. Our results are in agreement with recent experimental
findings (cond-mat/0503478) which evidence the presence of a topological defect
in the bilayer system.Comment: 9 pages, 3 figure
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins generated by repeat-associated, non-ATG translation. To address this question we developed in vitro and in vivo models to dissect repeat RNA and dipeptide repeat protein toxicity. Expression of pure repeats in Drosophila caused adult-onset neurodegeneration attributable to poly-(glycine-arginine) proteins. Thus, expanded repeats promoted neurodegeneration through neurotoxic proteins. Expression of individual dipeptide repeat proteins with a non-GGGGCC RNA sequence showed both poly-(glycine-arginine) and poly-(proline-arginine) proteins caused neurodegeneration. These findings are consistent with a dual toxicity mechanism, whereby both arginine-rich proteins and repeat RNA contribute to C9orf72-mediated neurodegeneration
Antiperiodic dynamical 6-vertex model I: Complete spectrum by SOV, matrix elements of the identity on separate states and connections to the periodic 8-vertex model
The spin-1/2 highest weight representations of the dynamical 6-vertex and the
standard 8-vertex Yang-Baxter algebra on a finite chain are considered in this
paper. For the antiperiodic dynamical 6-vertex transfer matrix defined on
chains with an odd number of sites, we adapt the Sklyanin's quantum separation
of variable (SOV) method and explicitly construct SOV representations from the
original space of representations. We provide the complete characterization of
eigenvalues and eigenstates proving also the simplicity of its spectrum.
Moreover, we characterize the matrix elements of the identity on separated
states by determinant formulae. The matrices entering in these determinants
have elements given by sums over the SOV spectrum of the product of the
coefficients of separate states. This SOV analysis is not reduced to the case
of the elliptic roots of unit and the results here derived define the required
setup to extend to the dynamical 6-vertex model the approach recently developed
in [1]-[5] to compute the form factors of the local operators in the SOV
framework, these results will be presented in a future publication. For the
periodic 8-vertex transfer matrix, we prove that its eigenvalues have to
satisfy a fixed system of equations. In the case of a chain with an odd number
of sites, this system of equations is the same entering in the SOV
characterization of the antiperiodic dynamical 6-vertex transfer matrix
spectrum. This implies that the set of the periodic 8-vertex eigenvalues is
contained in the set of the antiperiodic dynamical 6-vertex eigenvalues. A
criterion is introduced to find simultaneous eigenvalues of these two transfer
matrices and associate to any of such eigenvalues one nonzero eigenstate of the
periodic 8-vertex transfer matrix by using the SOV results. Moreover, a
preliminary discussion on the degeneracy of the periodic 8-vertex spectrum is
also presented.Comment: 36 pages, main modifications in section 3 and one appendix added, no
result modified for the dynamical 6-vertex transfer matrix spectrum and the
matrix elements of identity on separate states for chains with an odd number
of site
CFT description of the Fully Frustrated XY model and phase diagram analysis
Following a suggestion given in Nucl. Phys. B 300 (1988)611,we show how the
U(1)*Z_{2} symmetry of the fully frustrated XY (FFXY) model on a square lattice
can be accounted for in the framework of the m-reduction procedure developed
for a Quantum Hall system at "paired states" fillings nu =1 (cfr. Cristofano et
al.,Mod. Phys. Lett. A 15 (2000)1679;Nucl. Phys. B 641 (2002)547). The
resulting twisted conformal field theory (CFT) with central charge c=2 is shown
to well describe the physical properties of the FFXY model. In particular the
whole phase diagram is recovered by analyzing the flow from the Z_{2}
degenerate vacuum of the c=2 CFT to the infrared fixed point unique vacuum of
the c=3/2 CFT. The last theory is known to successfully describe the critical
behavior of the system at the overlap temperature for the Ising and
vortex-unbinding transitions.Comment: 18 pages, 1 figure, to appear in JSTA
Calcified Plaques in Patients With Acute Coronary Syndromes
OBJECTIVES: This study conducted detailed analysis of calcified culprit plaques in patients with acute coronary syndromes (ACS). BACKGROUND: Calcified plaques as an underlying pathology in patients with ACS have not been systematically studied. METHODS: From 1,241 patients presenting with ACS who had undergone pre-intervention optical coherence tomography imaging, 157 (12.7%) patients were found to have a calcified plaque at the culprit lesion. Calcified plaque was defined as a plaque with superficial calcification at the culprit site without evidence of ruptured lipid plaque. RESULTS: Three distinct types were identified: eruptive calcified nodules, superficial calcific sheet, and calcified protrusion (prevalence of 25.5%, 67.4%, and 7.1%, respectively). Eruptive calcified nodules were frequently located in the right coronary arteries (44.4%), whereas superficial calcific sheet was most frequently found in the left anterior descending coronary arteries (68.4%) (p = 0.012). Calcification index (mean calcification arc × calcification length) was greatest in eruptive calcified nodules, followed by superficial calcific sheet, and smallest in calcified protrusion (median 3,284.9 [interquartile range (IQR): 2,113.3 to 5,385.3] vs. 1,644.3 [IQR: 1,012.4 to 3,058.7] vs. 472.5 [IQR: 176.7 to 865.2]; p < 0.001). The superficial calcific sheet group had the highest peak post-intervention creatine kinase values among the groups (eruptive calcified nodules vs. superficial calcific sheet vs. calcified protrusion: 241 [IQR: 116 to 612] IU/l vs. 834 [IQR: 141 to 3,394] IU/l vs. 745 [IQR: 69 to 1,984] IU/l; p = 0.032). CONCLUSIONS: Three distinct types of calcified culprit plaques are identified in patients with ACS. Superficial calcific sheet, which is frequently located in the left anterior descending coronary artery, is the most prevalent type and is also associated with greatest post-intervention myocardial damage. (Identification of Predictors for Coronary Plaque Erosion in Patients With Acute Coronary Syndrome; NCT03479723).status: publishe
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila
G4C2 repeat expansions within the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeats undergo repeat-associated non-ATG translation to generate toxic dipeptide repeat proteins. Here, we show that insulin/Igf signalling is reduced in fly models of C9orf72 repeat expansion using RNA-sequencing of adult brain. We further demonstrate that activation of insulin/Igf signalling can mitigate multiple neurodegenerative phenotypes in flies expressing either expanded G4C2 repeats or the toxic dipeptide repeat protein poly-GR. Levels of poly-GR are reduced when components of the insulin/Igf signalling pathway are genetically activated in the diseased flies, suggesting a mechanism of rescue. Modulating insulin signalling in mammalian cells also lowers poly-GR levels. Remarkably, systemic injection of insulin improves the survival of flies expressing G4C2 repeats. Overall, our data suggest that modulation of insulin/Igf signalling could be an effective therapeutic approach against C9orf72 ALS/FTD
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