3,811 research outputs found
Modeling Bacterial DNA: Simulation of Self-avoiding Supercoiled Worm-Like Chains Including Structural Transitions of the Helix
Under supercoiling constraints, naked DNA, such as a large part of bacterial
DNA, folds into braided structures called plectonemes. The double-helix can
also undergo local structural transitions, leading to the formation of
denaturation bubbles and other alternative structures. Various polymer models
have been developed to capture these properties, with Monte-Carlo (MC)
approaches dedicated to the inference of thermodynamic properties. In this
chapter, we explain how to perform such Monte-Carlo simulations, following two
objectives. On one hand, we present the self-avoiding supercoiled Worm-Like
Chain (ssWLC) model, which is known to capture the folding properties of
supercoiled DNA, and provide a detailed explanation of a standard MC simulation
method. On the other hand, we explain how to extend this ssWLC model to include
structural transitions of the helix.Comment: Book chapter to appear in The Bacterial Nucleoid, Methods and
Protocols, Springer serie
A Universal Lifetime Distribution for Multi-Species Systems
Lifetime distributions of social entities, such as enterprises, products, and
media contents, are one of the fundamental statistics characterizing the social
dynamics. To investigate the lifetime distribution of mutually interacting
systems, simple models having a rule for additions and deletions of entities
are investigated. We found a quite universal lifetime distribution for various
kinds of inter-entity interactions, and it is well fitted by a
stretched-exponential function with an exponent close to 1/2. We propose a
"modified Red-Queen" hypothesis to explain this distribution. We also review
empirical studies on the lifetime distribution of social entities, and
discussed the applicability of the model.Comment: 10 pages, 6 figures, Proceedings of Social Modeling and Simulations +
Econophysics Colloquium 201
Climate Dynamics: A Network-Based Approach for the Analysis of Global Precipitation
Precipitation is one of the most important meteorological variables for defining the climate dynamics, but the spatial patterns of precipitation have not been fully investigated yet. The complex network theory, which provides a robust tool to investigate the statistical interdependence of many interacting elements, is used here to analyze the spatial dynamics of annual precipitation over seventy years (1941-2010). The precipitation network is built associating a node to a geographical region, which has a temporal distribution of precipitation, and identifying possible links among nodes through the correlation function. The precipitation network reveals significant spatial variability with barely connected regions, as Eastern China and Japan, and highly connected regions, such as the African Sahel, Eastern Australia and, to a lesser extent, Northern Europe. Sahel and Eastern Australia are remarkably dry regions, where low amounts of rainfall are uniformly distributed on continental scales and small-scale extreme events are rare. As a consequence, the precipitation gradient is low, making these regions well connected on a large spatial scale. On the contrary, the Asiatic South-East is often reached by extreme events such as monsoons, tropical cyclones and heat waves, which can all contribute to reduce the correlation to the short-range scale only. Some patterns emerging between mid-latitude and tropical regions suggest a possible impact of the propagation of planetary waves on precipitation at a global scale. Other links can be qualitatively associated to the atmospheric and oceanic circulation. To analyze the sensitivity of the network to the physical closeness of the nodes, short-term connections are broken. The African Sahel, Eastern Australia and Northern Europe regions again appear as the supernodes of the network, confirming furthermore their long-range connection structure. Almost all North-American and Asian nodes vanish, revealing that extreme events can enhance high precipitation gradients, leading to a systematic absence of long-range patterns
Evaluating Active U: an Internet-mediated physical activity program.
Background:
Engaging in regular physical activity can be challenging, particularly during the winter months. To promote physical activity at the University of Michigan during the winter months, an eight-week Internet-mediated program (Active U) was developed providing participants with an online physical activity log, goal setting, motivational emails, and optional team participation and competition.
Methods:
This study is a program evaluation of Active U. Approximately 47,000 faculty, staff, and graduate students were invited to participate in the online Active U intervention in the winter of 2007. Participants were assigned a physical activity goal and were asked to record each physical activity episode into the activity log for eight weeks. Statistics for program reach, effectiveness, adoption, and implementation were calculated using the Re-Aim framework. Multilevel regression analyses were used to assess the decline in rates of data entry and goal attainment during the program, to assess the likelihood of joining a team by demographic characteristics, to test the association between various predictors and the number of weeks an individual met his or her goal, and to analyze server load.
Results:
Overall, 7,483 individuals registered with the Active U website (≈16% of eligible), and 79% participated in the program by logging valid data at least once. Staff members, older participants, and those with a BMI < 25 were more likely to meet their weekly physical activity goals, and average rate of meeting goals was higher among participants who joined a competitive team compared to those who participated individually (IRR = 1.28, P < .001).
Conclusion:
Internet-mediated physical activity interventions that focus on physical activity logging and goal setting while incorporating team competition may help a significant percentage of the target population maintain their physical activity during the winter months
Instability of black hole formation under small pressure perturbations
We investigate here the spectrum of gravitational collapse endstates when
arbitrarily small perfect fluid pressures are introduced in the classic black
hole formation scenario as described by Oppenheimer, Snyder and Datt (OSD) [1].
This extends a previous result on tangential pressures [2] to the more
physically realistic scenario of perfect fluid collapse. The existence of
classes of pressure perturbations is shown explicitly, which has the property
that injecting any smallest pressure changes the final fate of the dynamical
collapse from a black hole to a naked singularity. It is therefore seen that
any smallest neighborhood of the OSD model, in the space of initial data,
contains collapse evolutions that go to a naked singularity outcome. This gives
an intriguing insight on the nature of naked singularity formation in
gravitational collapse.Comment: 7 pages, 1 figure, several modifications to match published version
on GR
Characterization of complex networks: A survey of measurements
Each complex network (or class of networks) presents specific topological
features which characterize its connectivity and highly influence the dynamics
of processes executed on the network. The analysis, discrimination, and
synthesis of complex networks therefore rely on the use of measurements capable
of expressing the most relevant topological features. This article presents a
survey of such measurements. It includes general considerations about complex
network characterization, a brief review of the principal models, and the
presentation of the main existing measurements. Important related issues
covered in this work comprise the representation of the evolution of complex
networks in terms of trajectories in several measurement spaces, the analysis
of the correlations between some of the most traditional measurements,
perturbation analysis, as well as the use of multivariate statistics for
feature selection and network classification. Depending on the network and the
analysis task one has in mind, a specific set of features may be chosen. It is
hoped that the present survey will help the proper application and
interpretation of measurements.Comment: A working manuscript with 78 pages, 32 figures. Suggestions of
measurements for inclusion are welcomed by the author
The International-Trade Network: Gravity Equations and Topological Properties
This paper begins to explore the determinants of the topological properties
of the international - trade network (ITN). We fit bilateral-trade flows using
a standard gravity equation to build a "residual" ITN where trade-link weights
are depurated from geographical distance, size, border effects, trade
agreements, and so on. We then compare the topological properties of the
original and residual ITNs. We find that the residual ITN displays, unlike the
original one, marked signatures of a complex system, and is characterized by a
very different topological architecture. Whereas the original ITN is
geographically clustered and organized around a few large-sized hubs, the
residual ITN displays many small-sized but trade-oriented countries that,
independently of their geographical position, either play the role of local
hubs or attract large and rich countries in relatively complex
trade-interaction patterns
Temporal networks of face-to-face human interactions
The ever increasing adoption of mobile technologies and ubiquitous services
allows to sense human behavior at unprecedented levels of details and scale.
Wearable sensors are opening up a new window on human mobility and proximity at
the finest resolution of face-to-face proximity. As a consequence, empirical
data describing social and behavioral networks are acquiring a longitudinal
dimension that brings forth new challenges for analysis and modeling. Here we
review recent work on the representation and analysis of temporal networks of
face-to-face human proximity, based on large-scale datasets collected in the
context of the SocioPatterns collaboration. We show that the raw behavioral
data can be studied at various levels of coarse-graining, which turn out to be
complementary to one another, with each level exposing different features of
the underlying system. We briefly review a generative model of temporal contact
networks that reproduces some statistical observables. Then, we shift our focus
from surface statistical features to dynamical processes on empirical temporal
networks. We discuss how simple dynamical processes can be used as probes to
expose important features of the interaction patterns, such as burstiness and
causal constraints. We show that simulating dynamical processes on empirical
temporal networks can unveil differences between datasets that would otherwise
look statistically similar. Moreover, we argue that, due to the temporal
heterogeneity of human dynamics, in order to investigate the temporal
properties of spreading processes it may be necessary to abandon the notion of
wall-clock time in favour of an intrinsic notion of time for each individual
node, defined in terms of its activity level. We conclude highlighting several
open research questions raised by the nature of the data at hand.Comment: Chapter of the book "Temporal Networks", Springer, 2013. Series:
Understanding Complex Systems. Holme, Petter; Saram\"aki, Jari (Eds.
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