CoForTips Congo basin forests: tipping points for biodiversity conservation and resilience. Final Report (La modélisation des changements d’utilisation des terres dans les pays d’Afrique Centrale 2000-2030)

L'utilisation des terres est un facteur crucial pour le développement économique et l'environnement. Ainsi une terre dédiée à l’agriculture permettra une production régulière qui sera bénéfique pour satisfaire les besoins alimentaires des populations alentour et potentiellement, pour l’économie dans son ensemble. Par contre, les terres agricoles ont un contenu carbone bien inférieur à une terre forestière et sont généralement pauvres en biodiversité. Les terres peuvent être utilisées de différentes manières afin de répondre à différents objectifs et il peut être potentiellement difficile de satisfaire tous ces objectifs à la fois, donnant lieu à des choix difficiles lors de la conception des politiques. Les pays membres de la Commission des forêts d'Afrique centrale (COMIFAC) ont identifié l’initiative pour la réduction des émissions issues de la déforestation et de la dégradation forestière et l'amélioration des stocks de carbone (REDD+) comme un enjeu majeur dans la dernière revision du Plan de Convergence pour la Gestion Durable des Forêts, aux côtés de la conservation et de l’utilisation durable de la diversité biologique et de la réduction des impacts du changement climatique. Cette étude a pour objectif d’identifier les zones soumises aux pressions de conversion les plus fortes dans le futur et les conséquences en termes de production agricole, d’émissions de gaz à effet de serre (GES) et de risque de perte de biodiversité, avec pour but d’accompagner les institutions impliquées dans la REDD+ ainsi que dans la planification des Stratégies Nationales et Plans d’Action pour la Biodiversité dans les pays de la COMIFAC

Modelling Land Use Changes in the Republic of Congo 2000-2030 . A report by the REDD-PAC project.

This study is intended to assist institutions involved in REDD+ and the planning of National Strategies and Action plans for Biodiversity in the Republic of Congo by attempting to identify the areas under the greatest conversion pressures in the future and the consequences in terms of agricultural production, greenhouse gas emissions and biodiversity loss.Cette étude essaye d’identifier les zones soumises aux pressions de conversion les plus fortes dans le futur et les conséquences en termes de production agricole, d’émissions de gaz à effet de serre et de risque de perte de biodiversité. L’objectif du projet REDD-PAC est d’accompagner les institutions impliquées dans la REDD+ ainsi que dans la planification de la Stratégie Nationale et du Plan d’Action pour la Biodiversité en République du Congo

Using models to inform policies to meet multiple objectives. Sustainable development, climate change mitigation and biodiversity conservation in Central Africa

Land-use change models can help in developing a holistic understanding of the range of potential impacts of different land-use related policy options, and so strengthen the development and implementation of policies to meet a range of objectives; including sustainable development, climate change mitigation, food security and biodiversity conservation. Member countries of the Central Africa Forest Commission (COMIFAC) have committed to sustainable management of the region’s forests, including under the COMIFAC “Convergence Plan”, and to achieving the Sustainable Development Goals (SDGs). Achieving these objectives is dependent on the development, and implementation, of new and existing national policies and approaches. Projections from land-use modelling identify potential trade-offs and synergies in the achievement of the SDGs under different macro-economic and land-use policy related scenarios. In particular they highlight the importance of effective protected areas and forest concessions for the conservation of Great Apes and other threatened species, and show that maintaining these areas has negligible impact on agricultural production in the region. As development continues in the region, further increasing the extent of protected areas could play a role in greatly reducing the number of species losing a large proportion of their habitat. However, protected area expansion needs to be well planned to avoid adverse impacts on particular species and societal challenges such as food security

Modelling future land use changes in Central Africa 2000-2030. A report by the REDD-PAC project. Short report

This study is intended to assist institutions involved in REDD+ and the planning of National Strategies and Action plans for Biodiversity in COMIFAC countries by attempting to identify the areas under the greatest conversion pressures in the future and the consequences in terms of agricultural production, greenhouse gas emissions and biodiversity loss

Efficacy and safety of pafuramidine versus pentamidine maleate for treatment of first stage sleeping sickness in a randomized, comparator-controlled, international phase 3 clinical trial

Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration. In previous studies, orally administered pafuramidine was well tolerated in healthy patients (for up to 21 days) and stage 1 HAT patients (for up to 10 days), and demonstrated efficacy comparable to pentamidine.; This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospitals in the Democratic Republic of the Congo between August 2005 and September 2009 to support the registration of pafuramidine for treatment of first stage HAT in collaboration with the United States Food and Drug Administration. Patients were treated with either 100 mg of pafuramidine orally twice a day for 10 days or 4 mg/kg pentamidine intramuscularly once daily for 7 days to assess the efficacy and safety of pafuramidine versus pentamidine. Pregnant and lactating women as well as adolescents were included. The primary efficacy endpoint was the combined rate of clinical and parasitological cure at 12 months. The primary safety outcome was the frequency and severity of adverse events. The study was registered on the International Clinical Trials Registry Platform at www.clinicaltrials.gov with the number ISRCTN85534673.; The overall cure rate at 12 months was 89% in the pafuramidine group and 95% in the pentamidine group; pafuramidine was non-inferior to pentamidine as the upper bound of the 95% confidence interval did not exceed 15%. The safety profile of pafuramidine was superior to pentamidine; however, 3 patients in the pafuramidine group had glomerulonephritis or nephropathy approximately 8 weeks post-treatment. Two of these events were judged as possibly related to pafuramidine. Despite good tolerability observed in preceding studies, the development program for pafuramidine was discontinued due to delayed post-treatment toxicity

Modelling land use changes in Cameroon 2000-2030. A report by the REDD-PAC project. Short report

This study is intended to assist institutions involved in REDD+ and the planning of National Strategies and Action plans for Biodiversity in Cameroon. It identifies the areas under the greatest conversion pressures in the future and the consequences in terms of agricultural production, greenhouse gas emissions and biodiversity loss.Le Cameroun est engagé dans le processus REDD+ depuis 2005, notamment au niveau sous régional avec la COMIFAC et plus d’une trentaine de projets de type REDD+ seraient actuellement en cours au Cameroun. Cette étude a pour objectif d’identifier les zones soumises aux pressions de conversion les plus fortes dans le futur et les conséquences en termes de production agricole, d’émissions de gaz à effet de serre et de risque de perte de biodiversité, avec pour but d’accompagner les institutions impliquées dans la REDD+ ainsi que dans la planification des Stratégies Nationales et Plans d’Action pour la Biodiversité au Cameroun