DA-EPOCH-R combined with high-dose methotrexate in patients with newly diagnosed stage II-IV CD5-positive diffuse large B-cell lymphoma: a single-arm, open-label, phase II study

CD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) is characterized by poor prognosis and a high frequency of central nervous system relapse after standard immunochemotherapy. We conducted a phase II study to investigate the efficacy and safety of dose-adjusted (DA)- EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) combined with high-dose methotrexate (HD-MTX) in newly diagnosed patients with CD5+ DLBCL. Previously untreated patients with stage II to IV CD5+ DLBCL according to the 2008 World Health Organization classification were eligible. Four cycles of DA-EPOCH-R followed by two cycles of HD-MTX and four additional cycles of DAEPOCH- R (DA-EPOCH-R/HD-MTX) were planned as the protocol treatment. The primary end point was 2-year progression-free survival (PFS). Between September 25, 2012, and November 11, 2015, we enrolled 47 evaluable patients. Forty-five (96%) patients completed the protocol treatment. There were no deviations or violations in the DA-EPOCH-R dose levels. The complete response rate was 91%, and the overall response rate was 94%. At a median follow up of 3.1 years (range, 2.0-4.9 years), the 2- year PFS was 79% [95% confidence interval (CI): 64-88]. The 2-year overall survival was 89% (95%CI: 76-95). Toxicity included grade 4 neutropenia in 46 (98%) patients, grade 4 thrombocytopenia 12 (26%) patients, and febrile neutropenia in 31 (66%) patients. No treatment-related death was noted during the study. DA-EPOCH-R/HD-MTX might be a first-line therapy option for stage II-IV CD5+ DLBCL and warrants further investigation. (Trial registered at: UMIN-CTR: UMIN000008507.

Qualification Test Results of IMM Triple-Junction Solar Cells, Space Solar Sheets, and Lightweight&Compact Solar Paddle

Development of a high specific power, low stowage volume and lightweight solar paddle utilizing high-efficiency, thin-film, InGaP/GaAs/InGaAs inverted metamorphic triple-junction solar cell has been completed. The cell exhibits the efficiency of as high as 32% with sufficient radiation resistance. Owing to the high efficiency of the cell, the paddle achieved the specific power of greater than 150 W/kg. Qualification and reliability tests for the cell and paddle were carried out. The results confirmed that both the cell and paddle have enough capability to use them in space. Space demonstration of the paddle is now in preparation

Qualification Test Results of IMM Triple-Junction Solar Cells, Space Solar Sheets, and Lightweight&Compact Solar Paddle

Development of a high specific power, low stowage volume and lightweight solar paddle utilizing high-efficiency, thin-film, InGaP/GaAs/InGaAs inverted metamorphic triple-junction solar cell has been completed. The cell exhibits the efficiency of as high as 32% with sufficient radiation resistance. Owing to the high efficiency of the cell, the paddle achieved the specific power of greater than 150 W/kg. Qualification and reliability tests for the cell and paddle were carried out. The results confirmed that both the cell and paddle have enough capability to use them in space. Space demonstration of the paddle is now in preparation