1 research outputs found
<span style="font-size:11.0pt;font-family: "Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;letter-spacing:-.1pt;mso-ansi-language:EN-GB;mso-fareast-language:EN-US; mso-bidi-language:HI" lang="EN-GB">Physicochemical and chromatographic evaluation of <i>Shivakshar Pachan Churna</i></span>
609-613<span style="font-size:11.0pt;font-family:
" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";mso-bidi-font-family:="" mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;mso-bidi-language:="" hi"="" lang="EN-GB">In the present study, an attempt was made to formulate in-house ‘Shivakshar Pachan Churna’, (IN) which
was compared with some marketed preparations. (R, Z and V) The study included
determination of various physicochemical and phytochemical evaluations which
was followed by Chromatographic evaluations (TLC and HPTLC) of the
formulations. Further, the study included standardization of these formulations
by developing a simple, precise and accurate High Performance Thin Layer
Chromatography (HPTLC) method using Ferulic acid (99%) as chemical marker.
Chromatographic analysis was performed on silica gel 60 F254 precoated TLC
plates using Toluene: Ethyl acetate: Formic acid
(14:8:
0.15 v/v/v) for Ferulic acid as mobile phase. The Rf values
of Ferulic acid was the basis of confirmation of this marker. The total peak
areas of standard marker and corresponding formulations were compared and their
contents were estimated in all the formulations. From the results, we observed
that, all the physicochemical properties were found to be within the prescribed
pharmacopoeial limits. The results also demonstrated that, <span style="font-size:11.0pt;
font-family:" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:mangal;mso-ansi-language:en-in;mso-fareast-language:en-us;="" mso-bidi-language:hi;mso-bidi-font-weight:bold"="">marketed formulations Z and V
had a lowest concentration of Ferulic acid, while laboratory prepared
formulations contained more concentration. <span style="font-size:11.0pt;
font-family:" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:mangal;mso-ansi-language:en-in;mso-fareast-language:en-us;="" mso-bidi-language:hi"="">In conclusion, the analytical method developed herein for
standardization of ‘<span style="font-size:11.0pt;
font-family:" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:mangal;mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:hi"="" lang="EN-GB">Shivakshar Pachan Churna’ will be helpful in obtaining
a quality control profile of this formulation.</span