10,592 research outputs found
Back to Basics: International Collection Development on a Shoestring
This article explores collection development for small libraries facing an extremely restricted budget, with an additional focus on international school libraries. Drawing on the author’s experience as a professional consultant for Oasis International School, Ankara, Turkey, this case study provides collection development advice, tips for librarians interested in volunteering or international travel, and a literature review. The article shows how an extremely restricted budget and the complexities of an international environment need not prevent libraries from taking steps towards improving their collection. Strategies include: seeking targeted donations from publishers, granting organizations, individuals, and others; intelligently exploiting non-targeted donations; utilizing volunteers; carefully balancing preservation and access; and implementing a basic inventory/circulation system
Intramuscular lipid oxidation and obesity
There is an accumulating amount of evidence indicating that lipid oxidation is depressed in the skeletal muscle of obese individuals. Decrements in fatty acid oxidation (FAO) have been reported with obesity in models ranging from whole body measurements to isolated skeletal muscle preparations as well as in myotubes raised in culture. This reduction appears to be associated with a depression in the activities of enzymes involved in various steps of lipid oxidation, which subsequently partitions lipid entering the cell toward storage. The defect in FAO in skeletal muscle may be critical in relation to health, as a reduction in the capacity for lipid oxidation could directly or indirectly contribute to the insulin resistance commonly evident with obesity. Although less characterized, a decrement in FAO has also been linked with weight gain, which suggests that this characteristic may be an integral aspect leading to the obese state. In terms of intervention, weight loss does not seem to correct the defect in FAO with obesity. This review will provide evidence supporting a reduction in muscle FAO with obesity. Originally published AJP - Regulatory, Integrative and Comparative Physiology 294(4) 2009
Creating Cherokee Print:
The 1821 creation of a written syllabary for the Cherokee language by Sequoyah and its use in the
Nation’s newspaper, the Cherokee Phoenix, are routinely examined within the context of the tribe’s discourse surrounding removal in the 1830s, but scholars often overlook the influence of the missionary Samuel Austin Worcester and the American Board of Commissioners for Foreign Missions (ABCFM) in shaping the parameters of that discourse by arranging the syllabary, typesetting the characters, and establishing the press. This article illuminates these significant historical and technical aspects of Worcester’s influence on the creation of Cherokee print. Worcester’s influence on the Cherokee syllabary
is important, given the enduring nature of his influence and the rapid adoption of the written language: within fourteen years of its introduction, and seven years of the first printing, more than half of all households in the Cherokee Nation had a reader of Cherokee. Today, nearly 180 years after Worcester first standardized Cherokee characters in print, his forms of the syllabic characters guide instruction in reading and writing Cherokee, and his translation of the Bible into Cherokee persists in Cherokee homes
One along side the other : the collected letters of William Carlos Williams and Kenneth Burke
The collected letters of William Carlos Williams and Kenneth Burke from the Beineke Library at Yale, the Pattee Library at The Pennsylvania State University, and the Kenneth Burke estate, which span the entire forty-two years .of their relationship from 1921-1962, have been collected, collated, annotated, and introduced. The introduction describes their first meeting, offers a brief look at their lives and works, and contrasts their relationship with that of the attenuated image created by the John C. Thirlwall Selected Letters of William Carlos Williams (1957). The introduction goes on to examine the nature of their relationship as reflected by The Collected Letters and information gathered from interviews with Kenneth Burke, Michael Burke, and Bill Williams, Jr., as well as other sources and concludes with a brief characterization of the nature of their collaboration
Nationwide Insecticide Susceptibility Screening Against Six Active Ingredients
Presented for World Environmental Health Day, September 26, 2016 in Greenville, North Carolina.Mosquitoes may develop resistance to
insecticide active ingredients after
repeated exposures. Thus, it is crucial that
mosquito populations be tested for
resistance to confirm efficacy of control,
inform management decisions, and protect
public and environmental health.
Nationwide Insecticide Susceptibility Screening Against Six Active Ingredients
Objectives
1) Determine a baseline of resistance for six
active ingredients commonly used in
mosquito control in the United States.
2) Assess the extent to which resistance
differs between active ingredients and
mosquito genera.This study was funded by Bayer Crop Science
Associations between farmers market managers’ motivations and market-level Supplemental Nutrition Assistance Program Electronic Benefit Transfer (SNAP/EBT) availability and business vitality
Ward, R., Slawson, D., Wu, Q., & Pitts, S. J. (2015). Associations between farmers market managers’ motivations and market-level Supplemental Nutrition Assistance Program Electronic Benefit Transfer (SNAP/EBT) availability and business vitality. Journal of Agriculture, Food Systems, and Community Development, 6(1), 121–130. http://dx.doi.org/10.5304/jafscd.2015.061.010. Licensed under a CC BY 4.0 license.Farmers markets are promoted to improve access
to healthy food for low-income consumers by
providing affordable produce via Supplemental
Nutrition Assistance Program Electronic Benefit
Transfer (SNAP/EBT). Having SNAP/EBT at
markets also expands revenue opportunities for
participating farmers. Market managers play a key
role in implementing SNAP/EBT and promoting
business opportunities for farmers, yet they are not
motivated equally by public health and business
goals. There are few studies examining market
managers’ influence on food access for low-income
households and business opportunities for farmers.
We examined associations between managers’
motivations and (1) food access for low-income
households, measured by SNAP/EBT availability,
and (2) business vitality, measured by vendor
participation. A survey assessing manager motivation, SNAP/EBT availability, and vendor participation was sent to all market managers
(N=271) in North Carolina. Seventy (26%)
managers completed the survey. Multiple
regression models were used to examine the
association between managers’ motivations to (1)
improve access to healthful food and SNAP/EBT
availability, and to (2) support business
opportunities and total vendor count, weekly
vendor count, and the number of vendors who sell
only what they produce (“producer-only�). There
was no significant association between food access
motivation and SNAP/EBT availability, or
business motivation and total and weekly vendor
count. A high business motivation score was
positively associated with having 13 more
producer-only vendors at the market. Manager pay
was positively correlated with vendor participation,
including total vendor, weekly, and producer-only
vendor counts. Our results suggest that public
health interventions should emphasize the business
opportunities offered by SNAP/EBT at farmers’
markets, ultimately leveraging market managers’
business goals to encourage SNAP/EBT
implementation.ECU Open Access Publishing Support Fun
Overview of Attention Deficit Hyperactivity Disorder in Young Children
Attention deficit hyperactivity disorder (ADHD) is a complex disorder, which can be seen as a disorder of life time, developing in preschool years and manifesting symptoms (full and/or partial) throughout the adulthood; therefore, it is not surprising that there are no simple solutions. The aim of this paper is to provide a short and concise review which can be used to inform affected children and adults; family members of affected children and adults, and other medical, paramedical, non-medical, and educational professionals about the disorder. This paper has also tried to look into the process of how ADHD develops; what are the associated problems; and how many other children and adults are affected by such problems all over the world basically to understand ADHD more precisely in order to develop a better medical and or non-medical multimodal intervention plan. If preschool teachers and clinicians are aware of what the research tells us about ADHD, the varying theories of its cause, and which areas need further research, the knowledge will assist them in supporting the families of children with ADHD. By including information in this review about the connection between biological behavior, it is hoped that preschool teachers and clinicians at all levels will feel more confident about explaining to parents of ADHD children, and older ADHD children themselves about the probable causes of ADHD
Polytobacco use and multiple-product smoking among a random community sample of African-American adults
Objectives Little is known about polytobacco use among African-American adults. This study is the first to explore this among a random, statewide, community sample of African-American adults.
Setting Community-based sampling obtained a random, household-probability sample of African-American adults from California, surveyed door to door in randomly selected census tracts statewide.
Participants Participants were a statewide, random-household sample of N=2118 African-American adults from California who completed a survey on past 30-day smoking of cigarettes, blunts, bidis, kreteks, cigarillos, marijuana and cigars.
Results Almost half (49.3%) of the African-American cigarette-smokers and 14.9% of the cigarette non-smokers had smoked at least one non-cigarette product in the past 30 days. Smokers had a substantial prevalence of smoking cigarillos (28.7%) and blunts (27.7%). Logistic regressions revealed that the odds of smoking most of the non-cigarette products were higher for cigarette smokers and men, inversely related to age, and unrelated to socioeconomic status. However, smoking of blunts, bidis and kreteks was not predicted by cigarette smoking.
Conclusions Smoking of cigarillos (eg, Phillies, Black & Mild) and blunts may be prevalent among African-American cigarette-smokers and non-smokers alike, but such products are not examined in most population-level smoking research. Smoking of these products should be included in surveillance studies, in cancer prevention programmes and in healthcare provider-assessment of smoking, and addressed in smoking cessation programmes as well
JunD/HBZ enhances HBZ enhances HTLV-1 antisense transcription
Infection with the human T-cell leukemia virus type 1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia (ATL), a fatal malignancy characterized by the uncontrolled proliferation of virally infected CD4+ T cells. The HTLV-1 basic leucine zipper factor (HBZ) is believed to contribute to development and maintenance of ATL. Unlike the other HTLV-1 genes, the hbz gene is encoded on the complementary strand of the provirus and therefore is not under direct control of the promoter within the 5′ long terminal repeat (LTR) of the provirus. This promoter can undergo inactivating genetic or epigenetic changes during the course of ATL that eliminates expression of all viral genes except that of hbz. In contrast, repressive modifications are not known to occur on the hbz promoter located in the 3′ LTR, and hbz expression has been consistently detected in all ATL patient samples. Although Sp1 regulates basal transcription from the HBZ promoter, other factors that activate transcription remain undefined. In this study, we used a proviral reporter construct deleted of the 5′ LTR to show that HBZ upregulates its own expression through cooperation with JunD. Activation of antisense transcription was apparent in serum-deprived cells in which the level of JunD was elevated, and elimination of JunD expression by gene knockout or shRNA-mediated knockdown abrogated this effect. Activation through HBZ and JunD additionally required Sp1 binding at the hbz promoter. These data favor a model in which JunD is recruited to the promoter through Sp1, where it heterodimerizes with HBZ thereby enhancing its activity. Separately, hbz gene expression led to an increase in JunD abundance, and this effect correlated with emergence of features of transformed cells in immortalized fibroblasts. Overall, our results suggest that JunD represents a novel therapeutic target for the treatment of ATL
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