49,651 research outputs found

    Systems thinking: critical thinking skills for the 1990s and beyond

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    This pdf article discusses the need for teaching systems thinking and critical thinking skills. Systems thinking and systems dynamics are important for developing effective strategies to close the gap between the interdependent nature of our problems and our ability to understand them. This article calls for a clearer view of the nature of systems thinking and the education system into which it must be transferred. Educational levels: Graduate or professional

    Thin film process forms effective electrical contacts on semiconductor crystals

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    Process makes microscopic, low-resistance electrical contacts on hexagonal n-type silicon carbide crystals used for microelectronic devices. A vacuum deposition of aluminum is etched to expose the bare silicon carbide where the electrical contacts are made. Sputtering alternating layers of tantalum and gold forms the alloy film

    Experimental results of the control of a vortical flow by tangential blowing

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    The results of a wind tunnel test to investigate the controlling effects of tangential, leading edge blowing on the vortical flow over a delta wing are given. Blowing is used to directly control the crossflow separation points at the rounded leading edge and hence, the trajectory of the feeding sheet and the location of the vortex. Experiments were conducted for both co-flowing and counter-flowing configurations over a range of angles of attack from 0 to 90 degrees. Results in the form of pressure distributions, overall force coefficients and flow mappings were obtained. The emphasis is on data presentation rather than detailed analysis. The initial results indicate that the co-flowing configuration was capable of extending the regime of stable, controlled vortical flow over the upper surface by approximately 30 degrees angle of attack for modest blowing requirements. Increases in maximum normal force coefficient of approximately 30% were achieved and significant rolling moments produced at angles of attack from 30 to 60 degrees. The counter-flowing configuration indicated only minor lift augmentation with the exception of an isolated occurrence at 20 degrees angle of attack. At that condition, with very weak blowing, a lift augmentation of approximately 20 was measured

    Force on a moving point impurity due to quantum fluctuations in a Bose-Einstein condensate

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    An analytic expression is derived for a force on a weak point impurity arising from the scattering of quantum fluctuations in a slow-moving, weakly interacting, three-dimensional Bose-Einstein condensate at zero temperature. In an infinitely extended geometry, this force is shown to exist at any arbitrarily small flow velocity below Landau's critical velocity. Furthermore, this force is shown to be directly proportional to the flow speed.Comment: v2: corrected notation and other minor change

    Epitope mapping using mRNA display and a unidirectional nested deletion library

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    In vitro selection targeting an anti-polyhistidine monoclonal antibody was performed using mRNA display with a random, unconstrained 27-mer peptide library. After six rounds of selection, epitope-like peptides were identified that contain two to five consecutive, internal histidines and are biased for arginine residues, without any other identifiable consensus. The epitope was further refined by constructing a high-complexity, unidirectional fragment library from the final selection pool. Selection by mRNA display minimized the dominant peptide from the original selection to a 15-residue functional sequence (peptide Cmin: RHDAGDHHHHHGVRQ; K-D = 38 nM). Other peptides recovered from the fragment library selection revealed a separate consensus motif (ARRXA) C-terminal to the histidine track. Kinetics measurements made by surface plasmon resonance, using purified Fab (antigen-binding fragment) to prevent avidity effects, demonstrate that the selected peptides bind with 10- to 75-fold higher affinities than a hexahistidine peptide. The highest affinity peptides (K-D approximate to 10 nM) encode both a short histidine track and the ARRXA motif, suggesting that the motif and other flanking residues make important contacts adjacent to the core polyhistidine-binding site and can contribute > 2.5 kcal/mol of binding free energy. The fragment library construction methodology described here is applicable to the development of high-complexity protein or cDNA expression libraries for the identification of protein-protein interaction domains

    The worldwide costs of marine protected areas

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    Declines in marine harvests, wildlife, and habitats have prompted calls at both the 2002 World Summit on Sustainable Development and the 2003 World Parks Congress for the establishment of a global system of marine protected areas (MPAs). MPAs that restrict fishing and other human activities conserve habitats and populations and, by exporting biomass, may sustain or increase yields of nearby fisheries. Here we provide an estimate of the costs of a global MPA network, based on a survey of the running costs of 83 MPAs worldwide. Annual running costs per unit area spanned six orders of magnitude, and were higher in MPAs that were smaller, closer to coasts, and in high-cost, developed countries. Models extrapolating these findings suggest that a global MPA network meeting the World Parks Congress target of conserving 20–30% of the world’s seas might cost between 5billionand5 billion and 19 billion annually to run and would probably create around one million jobs. Although substantial, gross network costs are less than current government expenditures on harmful subsidies to industrial fisheries. They also ignore potential private gains from improved fisheries and tourism and are dwarfed by likely social gains from increasing the sustainability of fisheries and securing vital ecosystem services
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