"The first ones now, will later be last":understanding the importance of historical context when reading ESMO-MCBS scores

SCOPUS: ed.jinfo:eu-repo/semantics/publishe

A Review on Ayurvedic Medicinal Herbs as Remedial Perspective for COVID-19

Introduction: Recent outbreaks in a new type of coronavirus, novel coronavirus (COVID-19) disease causing respiratory infection have significantly hampered the public health. Medicinal plants used in traditional practices provide enormous scope to bring out viable alternatives against viral diseases, considering non-availability of suitable drug and increasing resistance to existing drug as well as re-emerging viral diseases. The present review on use of plants and related phytochemicals for the treatment of viral diseases particularly COVID-19, preclinical and clinical information is increased concern Methods: The methodological activities involved during a literature review were; (1) designing the review concept, (2) conducting the review on review papers, research papers, bulletins, official websites, (3) analysis of previous publications and (4) writing up the review paper. The integrative literature review and paper preparation process was done from our own practical experience and influenced by various standards and guidelines suggested in the publications. Results: Herbal medicines and their active phytochemicals against some viral pathogens including severe acute respiratory syndrome (SARS), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the virus that causes COVID-19 pandemic, middle east respiratory syndrome (MERS-COV), rhinovirus, human herpes virus (HSV-I & II), human immunodeficiency virus (HIV), coxsackievirus (CV), enterovirus 71 (EV71), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus, influenza A/H1N1 virus, coronavirus (CoV) etc were extensively reviewed. Ayurvedic herbal products could be useful to select as an alternative and integrated approach to decrease the morbidity and mortality associated with coronavirus infection and enhance host immunity against viral attack in the context of treatment vaccine of COVID-19 could be years away. Conclusion: The traditional practices and scientific evidence of several medicinal herbs and their phytochemicals against lethal viral infections in-vivo and in-vitro studies could be useful for the future as a novel source of natural products in particular focus on COVID-19

Overview of the 2020 WOSP 3C Citation Context Classification Task

The 3C Citation Context Classification task is the first shared task addressing citation context classification. The two subtasks, A and B, associated with this shared task, involves the classification of citations based on their purpose and influence, respectively. Both tasks use a portion of the new ACT dataset, developed by the researchers at The Open University, UK. The tasks were hosted on Kaggle, and the participated systems were evaluated using the macro f-score. Three teams participated in subtask A and four teams participated in subtask B. The best performing systems obtained an overall score of 0.2056 for subtask A and 0.5556 for subtask B, outperforming the simple majority class baseline models, which scored 0.11489 and 0.32249, respectively. In this paper we provide a report specifying the shared task, the dataset used, a short description of the participating systems and the final results obtained by the teams based on the evaluation criteria. The shared task has been organised as part of the 8th International Workshop on Mining Scientific Publications (WOSP 2020) workshop

Analysis of Yield Attributing Characters of Different Genotypes of Wheat in Rupandehi, Nepal

Field experiment was conducted at National Wheat Research Program, Bhairahawa, Rupandehi with the objective to identify high yielding superior wheat genotypes for Rupandehi district of Nepalduring 2014. Experiment was laid out in one factorial Randomized completely block design with ten wheat genotypes including both released and promising; Annapurna 1, Annapurna 3, Pasang Lahmu, Bijaya, BL 3623, Bhirkuti, NL 297, BL 4316, BL 3978 and BL 4347with three replications. The results showed that the grain yield of BL 3978 was found higher (4.03 t ha-1) than other genotypes followed by BL 4347 (3.93t ha-1). BL 3978 have also higher number of effective tillers m-2 and test weight. Among release varieties, NL 297 show higher yield (4 t ha-1) followed by Bhirkuti (3.43 t ha-1)and Bijaya (3.37 t ha-1). From this experiment it can be concluded that BL 3978 was found promising among all genotypes however should be tested at on-farms before promoted for general cultivation in Rupandehi district of Nepal

MiOXSYS andOxiSperm II assays appear to provide no clinical utility for determining oxidative stress in human sperm—results from repeated semen collections

OnlinePublBackground: Oxidative stress in semen contributes up to 80% of all infertility diagnosis. Diagnostics to measure oxidative stress in semen was recently added to the 6th edition WHO methods manual, although diagnostic predictive values need to be interpreted with caution as there are still several research questions yet to be answered. Objectives: To determine the natural fluctuations in semen redox indicators (MiOXSYS® and OxiSperm® II) within and between men and their association with markers of sperm oxidative stress. Materials and methods: Total, 118 repeat semen samples from 31 generally healthy men aged 18–45 years, over 6 months. Standard semen analysis as per 5th WHO manual. Semen redox levels measured via MiOXSYS® and OxiSperm® II. Additional attributes of sperm quality; HBA® binding assay and sperm hyperactivation and oxidative stress; DNA fragmentation (Halo® Sperm) and lipid peroxidation (BODIPY™ 581/591 C11) were assessed. Results: Samples with high redox-potential (MiOXSYS® ≥1.47 sORP/10⁶ sperm/ml) had lower sperm, motility, morphology and higher DNA fragmentation (P 0.05). Fluctuations in semen redox levels varied greater between men than within men over the study period. Discussion: Neither MiOXSYS® nor OxiSperm® II assays were predictive of sperm function or sperm oxidative stress. This was likely due at least in part to limited understanding of their biochemistry and clinical application. As a result, these assays seem to provide no additional clinical utility beyond that of a standard semen analysis, highlighting the imperative for the development of new robust point-of-care devices for accurately determining sperm oxidative stress. Conclusion: These findings suggest that MiOXSYS® and OxiSperm® II systems for the measurement of sperm oxidative stressmay have limited diagnostic potential.Patience Castleton, Prabin Gyawali, Nicola Mathews, Shadrack Mulinge Mutuku, David James Sharkey, Nicole Olivia McPherso

ANALYZING THE EFFECT OF CLIMATE CHANGE (RAINFALL AND TEMPERATURE) ON VEGETATION COVER OF NEPAL USING TIME SERIES MODIS IMAGES

Climate change and so its effect on terrestrial ecosystem has been a focus point for a while now. Among them, rainfall and temperature changes happen to exert a strong influence on the condition of vegetation cover. So, it is imperative to analyze the variation and inter-relationship between vegetation cover and climate pattern, especially country like Nepal having a dynamic ecosystem. This paper aims to analyze the spatial-temporal distribution of vegetation cover, temperature, and rainfall, and to examine the relationship of the latter two with vegetation for entire Nepal. Primary data used were vegetation and temperature data from Moderate Resolution Imaging Spectroradiometer (MODIS) and rainfall data from Climate Hazards Group Infrared Precipitation with Stations (CHIRPS) data product. The relationship analysis was carried out in three phases; first, the trend of vegetation with respect to rainfall and land surface temperature (LST) was inspected over entire study area by creating a time series of Normalized Difference Vegetation Index (NDVI) monthly means for six months, averaged over the whole study period. However, vegetation change pattern across various ecological regions of Nepal also needed to be considered, for the three different regions are profoundly different from each other in a number of factors like altitude and soil type. Finally, the variation of vegetation with climatic parameters, i.e. rainfall and temperature, along the eleven-year study period was also portrayed, to depict how the vegetation cover has been fluctuating over the years. During the study period, the correlation coefficient between vegetation index and rainfall was the highest in October in Terai while that with temperature was in July in Hilly region. Overall, vegetation was influenced greater by the temperature than rainfall in all three ecological regions with the highest correlation coefficient of vegetation with temperature and rainfall, being −0.937 and 0.556 respectively

Between GERD and NERD: the relevance of weakly acidic reflux

Nonerosive reflux disease (NERD) is a common condition and the most frequent phenotype of gastroesophageal reflux disease (GERD). NERD is extremely heterogeneous and includes patients with negative endoscopy but abnormal esophageal acid exposure and/or positive reflux-symptom association analysis (hypersensitive esophagus). This segregation is only possible owing to the use of impedance-pH monitoring. Indeed, weakly acidic reflux represents one of the most common causes of refractory symptoms in patients evaluated off antisecretory therapy and, more importantly, during antisecretory drug treatment. Patients with heartburn who do not have any type of reflux underlying their symptoms (functional heartburn) must be excluded from the category of GERD. The drawbacks of impedance-pH are mainly due to the day-to-day variability of the test and the fact that the accuracy of the symptom-reflux correlation scores is often far from perfect. Some histopathological characteristics, such as dilated intercellular spaces, can be helpful in distinguishing patients with NERD through esophageal biopsies. Patients with NERD in whom acid is the main pathogenetic factor respond successfully to proton pump inhibitor therapy, while those with hypersensitive esophagus to weakly acidic reflux could be treated with reflux inhibitors or surgery, although further controlled studies are required

Xanthan gum as an alternative to replace fat for coating and flavoring the extruded snacks

Food industries adapt their products and processes to the needs and desires of consumers. Extruded snacks include 10–20% fat sprinkled to fix flavors, seasonings, and salt. Considering the need to flavor snacks and simultaneously reduce the intake of calories, a polysaccharide is proposed in this study as a fat replacer. Impact of aqueous xanthan gum (Xg) solutions (0.25, 0.5, 1.0%) under two pH conditions (3.5 and 7.0) on structural and sensory characteristics of extruded snacks was analyzed. Rheological features of the coating solutions, as flow behaviour and viscoelastic profile (storage and loss moduli), were assessed. Texture analysis, to evaluate the snacks firmness and moisture content, water activity, retraction, and agglomeration index of the coated snacks, were also evaluated. Results for the aqueous Xg coatings were very encouraging showing good coating properties, not damaging the texture of the extrudates or causing agglomeration. Sensory analysis reflected a good overall acceptability of these snacks, as compared to oil-coated snacks. Therefore, xanthan gum should be used by the industry, to replace fat, on extruded snacks flavor coating solutionsinfo:eu-repo/semantics/publishedVersio