11 research outputs found
Enhanced Antioxidant Activities of Metal Conjugates of Curcumin Derivatives
Antioxidant properties of three Curcumin derivatives in which the 1,3-diketone system is
appended with nitrogen and sulfur donors and their copper conjugates are examined for the first time. Metal
conjugation seems to offer distinct advantages in radical scavenging activities of curcumin compounds
Synthesis and Characterization of Coordinatively Unsaturated Copper (II) Complexes of 1,3-Bis(2'-Pyridyl)-1,2-Diaza-2-Butene and Their Antityrosinase Activity
The coordinatively unsaturated copper (II) complexes of 1,3-bis(2'-pyridyl)-1,2-diaza-2-
butene with different ancillary anions were synthesized which can bind to copper centers of
tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against
mushroom tyrosinase and the nature and extent of inhibition is modulated according to the
type of ancillary anions
Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes
Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone)
was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum
complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry.
The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The
highest activity was found for the [Pt(TATSC)Cl1]
followed by [Cu(TATSC)Cl2]
and the ligand in
compariosn with cisplatin
Pre-formed iron-thiosemicarbazone chelates as ribonucleotide reductase inhibitors
1861-1864Pre-formed iron(III) complexes of
naphthoquinone thiosemicarbazone ligands, viz.
2-hydroxy-1,4-naphthoquinone-1-thiosemicarbazone (HNQTSC) and
2-thiosemicarbazido-1,4-
naphthoquinone (TSCNQ) have been synthesized,
characterized by various physical techniques and their potential for inhibition
of ribonucleotide reductase (RDR) enzyme, crucial for DNA synthesis, has also
been evaluated. It is observed that the pre-formed
iron(III) complexes possess higher RDR
inhibitory activity than the respective free ligands
<span style="font-size:12.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;color:black; mso-ansi-language:EN-IN;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">X-ray crystal structure of the cytotoxic planar Ni(II) complex of <sup>4</sup>N-dimethy <span style="font-size:12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family: Fd694969-Identity-H;color:black;mso-ansi-language:EN-IN;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">1-<span style="font-size:12.0pt; font-family:"Times New Roman","serif";mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin;color:black;mso-ansi-language:EN-IN; mso-fareast-language:EN-US;mso-bidi-language:AR-SA">2-acetylpyridine thiosemicarbazone</span></span></span>
981-984Transition
metal complexes of thiosemicarbazone ligands are emerging as a <span style="font-size:12.0pt;
font-family:" times="" new="" roman","serif";mso-fareast-font-family:calibri;="" mso-fareast-theme-font:minor-latin;color:#0f0f0f;mso-ansi-language:en-in;="" mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">new class of non-platinum
experimental anticancer chemotherapeutic compounds. 1-3<span style="font-size:12.0pt;
font-family:" times="" new="" roman","serif";mso-fareast-font-family:fd687457-identity-h;="" color:#0f0f0f;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" ar-sa"=""> The
observed cytotoxicities of the active complexes have been thought to arise from
their interaction with intracellular thiols such <span style="font-size:
12.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:fd687457-identity-h;="" color:#0f0f0f;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" ar-sa"="">as glutathiones
(GSH) generating a thiolato Complex of the type [ML]+ <span style="font-size:12.0pt;
font-family:" times="" new="" roman","serif";mso-fareast-font-family:calibri;="" mso-fareast-theme-font:minor-latin;color:#0f0f0f;mso-ansi-language:en-in;="" mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">which in turn <span style="font-size:12.0pt;
font-family:" times="" new="" roman","serif";mso-fareast-font-family:calibri;="" mso-fareast-theme-font:minor-latin;color:#0f0f0f;mso-ansi-language:en-in;="" mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">is capable of promoting
redox reactions with other thiols and oxygen generating the disulphide species (GSSG)
alongwith superoxide and hydroxyl radicals.<span style="font-size:
12.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:fd687457-identity-h;="" color:#0f0f0f;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" ar-sa"=""> 4
The other possibility involves the binding of the drug to the enzyme, viz.,
ribonucleotide reductase, an obligatory
enzyme for DNA synthesis, thereby hindering or blocking the DNA replication.</span
Immobilization of dithiooxamide in biopolymer and synthetic films for possible use in optical fibre copper probe
1397-1401Dithiooxamide
(DTO), a metallochromogenic reagent, has been immobilized in a composite biopolymer
matrix for the quantitative determination of CU(II) by an optical fibre method.
The suitability of the biopolymer matrix for immobilization purposes has been
determined from its stability in acid and basic media and absence of leaching
of the immobilized DTO and its copper complex. Immobilization of DTO in poly(methyl)methacrylate
(PMMA) alone shows characteristics comparable to that of the biopolymer matrix,
while polyvinyl alcohol (PYA ), polyvinyl chloride (PVC) and Nafion®
membranes are found to be unsuitable. A linear response is obtained for Cu(II) concentrations
between 1 to 5 ppm
Zeolite-encapsulated Cu(II)-salen complex as a catalyst for oxidation of cyclohexanol
1-3Cu (salen) complex encapsulated in zeolite Y is characterized by elemental analysis, IR, UV-vis and ESR spectroscopy and is shown to be a catalyst for the selective oxidation of cyclohexanol to cyclohexanone in the presence of H2O2 under much milder conditions (80°C) than those in current practice