Enhanced Antioxidant Activities of Metal Conjugates of Curcumin Derivatives

Antioxidant properties of three Curcumin derivatives in which the 1,3-diketone system is appended with nitrogen and sulfur donors and their copper conjugates are examined for the first time. Metal conjugation seems to offer distinct advantages in radical scavenging activities of curcumin compounds

Synthesis and Characterization of Coordinatively Unsaturated Copper (II) Complexes of 1,3-Bis(2'-Pyridyl)-1,2-Diaza-2-Butene and Their Antityrosinase Activity

The coordinatively unsaturated copper (II) complexes of 1,3-bis(2'-pyridyl)-1,2-diaza-2- butene with different ancillary anions were synthesized which can bind to copper centers of tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against mushroom tyrosinase and the nature and extent of inhibition is modulated according to the type of ancillary anions

Hormone Anchored Metal Complexes. 1. Synthesis, Structure, Spectroscopy and In Vitro Antitumor Activity of Testosterone Acetate Thiosemicarbazone and its Metal Complexes

Testosterone acetate thiosemicarbazone (TATSC, 17-β-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl1] followed by [Cu(TATSC)Cl2] and the ligand in compariosn with cisplatin

Pre-formed iron-thiosemicarbazone chelates as ribonucleotide reductase inhibitors

1861-1864Pre-formed iron(III) complexes of naphthoquinone thiosemicarbazone ligands, viz. 2-hydroxy-1,4-naphthoquinone-1-thiosemicarbazone (HNQTSC) and 2-thiosemicarbazido-1,4- naphthoquinone (TSCNQ) have been synthesized, characterized by various physical techniques and their potential for inhibition of ribonucleotide reductase (RDR) enzyme, crucial for DNA synthesis, has also been evaluated. It is observed that the pre-formed iron(III) complexes possess higher RDR inhibitory activity than the respective free ligands

<span style="font-size:12.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;color:black; mso-ansi-language:EN-IN;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">X-ray crystal structure of the cytotoxic planar Ni(II) complex of ⁴N-dimethy <span style="font-size:12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family: Fd694969-Identity-H;color:black;mso-ansi-language:EN-IN;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">1-<span style="font-size:12.0pt; font-family:"Times New Roman","serif";mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin;color:black;mso-ansi-language:EN-IN; mso-fareast-language:EN-US;mso-bidi-language:AR-SA">2-acetylpyridine thiosemicarbazone</span></span></span>

981-984Transition metal complexes of thiosemicarbazone ligands are emerging as a <span style="font-size:12.0pt; font-family:" times="" new="" roman","serif";mso-fareast-font-family:calibri;="" mso-fareast-theme-font:minor-latin;color:#0f0f0f;mso-ansi-language:en-in;="" mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">new class of non-platinum experimental anticancer chemotherapeutic compounds. 1-3<span style="font-size:12.0pt; font-family:" times="" new="" roman","serif";mso-fareast-font-family:fd687457-identity-h;="" color:#0f0f0f;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" ar-sa"=""> The observed cytotoxicities of the active complexes have been thought to arise from their interaction with intracellular thiols such <span style="font-size: 12.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:fd687457-identity-h;="" color:#0f0f0f;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" ar-sa"="">as glutathiones (GSH) generating a thiolato Complex of the type [ML]+ <span style="font-size:12.0pt; font-family:" times="" new="" roman","serif";mso-fareast-font-family:calibri;="" mso-fareast-theme-font:minor-latin;color:#0f0f0f;mso-ansi-language:en-in;="" mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">which in turn <span style="font-size:12.0pt; font-family:" times="" new="" roman","serif";mso-fareast-font-family:calibri;="" mso-fareast-theme-font:minor-latin;color:#0f0f0f;mso-ansi-language:en-in;="" mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">is capable of promoting redox reactions with other thiols and oxygen generating the disulphide species (GSSG) alongwith superoxide and hydroxyl radicals.<span style="font-size: 12.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:fd687457-identity-h;="" color:#0f0f0f;mso-ansi-language:en-in;mso-fareast-language:en-us;mso-bidi-language:="" ar-sa"=""> 4 The other possibility involves the binding of the drug to the enzyme, viz., ribonucleotide  reductase, an obligatory enzyme for DNA synthesis, thereby hindering or blocking the DNA replication.</span

Immobilization of dithiooxamide in biopolymer and synthetic films for possible use in optical fibre copper probe

1397-1401Dithiooxamide (DTO), a metallochromogenic reagent, has been immobilized in a composite biopolymer matrix for the quantitative determination of CU(II) by an optical fibre method. The suitability of the biopolymer matrix for immobilization purposes has been determined from its stability in acid and basic media and absence of leaching of the immobilized DTO and its copper complex. Immobilization of DTO in poly(methyl)methacrylate (PMMA) alone shows characteristics comparable to that of the biopolymer matrix, while polyvinyl alcohol (PYA ), polyvinyl chloride (PVC) and Nafion® membranes are found to be unsuitable. A linear response is obtained for Cu(II) concentrations between 1 to 5 ppm

Zeolite-encapsulated Cu(II)-salen complex as a catalyst for oxidation of cyclohexanol

1-3Cu (salen) complex encapsulated in zeolite Y is characterized by elemental analysis, IR, UV-vis and ESR spectroscopy and is shown to be a catalyst for the selective oxidation of cyclohexanol to cyclohexanone in the presence of H2O2 under much milder conditions (80°C) than those in current practice