1861-1864Pre-formed iron(III) complexes of
naphthoquinone thiosemicarbazone ligands, viz.
2-hydroxy-1,4-naphthoquinone-1-thiosemicarbazone (HNQTSC) and
2-thiosemicarbazido-1,4-
naphthoquinone (TSCNQ) have been synthesized,
characterized by various physical techniques and their potential for inhibition
of ribonucleotide reductase (RDR) enzyme, crucial for DNA synthesis, has also
been evaluated. It is observed that the pre-formed
iron(III) complexes possess higher RDR
inhibitory activity than the respective free ligands