Quality of Life in Grandparents After a Diagnosis of Acute Lymphoblastic Leukemia in Their Grandchild

The purpose of this study was to assess grandparents\u27 perceptions of their quality of life (QOL) after the diagnosis and treatment of acute lymphoblastic leukemia (ALL) in their grandchild. The following questions were addressed: (a) How do grandparents of children with ALL perceive their current QOL; (b) How do grandparents of children with ALL perceive their current QOL has changed since their grandchild was diagnosed; (c) What specific changes in QOL have grandparents experienced since the diagnosis of ALL in their grandchild; (d) What is the grandparents\u27 overall attitude about life with leukemia; (e) Is there a relationship between the length of time since the diagnosis of ALL in their grandchild and the grandparents\u27 current QOL; (f) Is there a relationship between length of time since the diagnosis of ALL in their grandchild and perceived changes in the grandparents\u27 QOL? Using Roy\u27s Adaptation Model as a theoretical framework, a descriptive research design was used. A convenience sample of 29 grandparents completed the Varricchio-Wright Impact of Leukemia Questionnaire-Grandparents and a Demographic Information Sheet. Measures of central tendency were used to answer the first two research questions. Grandparents\u27 perceived their current QOL to be good to neither good nor poor. They reported their QOL to be the same as prior to ALL in their grandchild. There was no relationship found between length of time from diagnosis and either current QOL or changes in QOL. Implications for nursing practice are discussed

Financial Consequences of Covid-19 for U.S. Hospitals

Introduction: The coronavirus pandemic has caused many financial issues for many businesses including putting a substantial strain on hospitals in the U.S. The impact of COVID-19 on the financial well-being of hospitals has been evaluated and the severity is still being measured as the pandemic is ongoing. The purpose of this research was to assess the financial consequences of the COVID-19 pandemic for hospitals in the United States. Methodology: A literature review with a semi-structured interview with an expert from a local hospital was used for the methodology of this qualitative study. Five government websites and five databases were used for this study. There was a total of twenty-six sources referenced in this literature review. Results: This literature review examined several studies as well as a semi-structured interview that supported the literature’s findings. The review also addressed the financial impact of COVID-19 on hospitals, financial impact of COVID-19 on specialties within the hospital, financial impact of COVID-19 on physicians within the hospital network, and resources to help with the financial impact of COVID-19. Discussion/Conclusion: The COVID-19 pandemic’s crippling aspects are further discussed which explains how it has debilitated many US hospitals. The negative financial impact on hospitals is discussed in further detail

Acute liver failure of unclear cause? Acetaminophen-protein adducts make the diagnosis

Acetaminophen poisoning remains a leading cause of acute liver failure. Some cases may be difficult to diagnose when clinical findings are equivocal, the patient\u27s history is misleading or incomplete, or the acetaminophen concentration is low or undetectable at arrival to care. We describe a case of a medically complicated young child whose acute liver failure had two of these features. Measurement of acetaminophen-protein adducts confirmed acetaminophen as the primary cause of her liver failure

An analysis of the systemic aspects of rights training for people with intellectual disabilities

Individuals with intellectual disabilities (ID) as a group have been subject to abuse. Individuals with ID need to be made aware of their rights. The 3Rs: Rights, Respect and Responsibility Human Rights Project is promoting rights awareness in individuals with ID, their caregivers and family members. To be effeCtive, abuse prevention must include support from the whole organization and its processes. This research evaluated the impact of the 3Rs initiative on the organization. It focused particularly on descriptions of organizational change perceived by full-time staff and managers in response to the initiation of the 3Rs Project. Behavioural interviews were conducted and a thematic analysis was used to describe changes in the organizational culture and behavioural mechanisms maintaining these changes. Systemic barriers to change were also explored. The results indicate that the Association is effectively implementing and supporting the rights-based philosophy

Art, Race, Space

poster abstractArt, Race, Space is a collaborative research project that takes as its starting point E Pluribus Unum, a public art installation proposed for the Indianapolis Culture Trail by renowned artist Fred Wilson that was cancelled in 2011 due to controversy surrounding Wilson’s appropriation of a freed slave figure from the Soldiers and Sailors Monument. Art, Race, Space” goes beyond examining the visual legacies of racial bondage to explore how the public responses to sculptures, memorials, and archaeology reveal our society’s faultlines of race and inequality. Building on the ideas about race, class, visual culture, and democratic debate that emerge from the Indianapolis project, the faculty have designed a multifaceted program to advance scholarship and promote civic dialogue about these significant issues. The faculty members organized an interdisciplinary symposium in January, 2013. Supported by an IAHI grant, the symposium explored the complicated relationships between art, race, and civic space with presentations by Wilson, community representatives who supported and opposed the sculpture, and scholars from a variety of disciplines who examined historical and cultural contexts of the controversy that had revealed Indianapolis’ longstanding racial and class tensions. The dialogue was expanded with the presentation of historical and contemporary examples from other parts of the United States. In order to encourage public dialogue, the symposium provided opportunities for audience members and presenters to engage in conversations, and it deployed social media (Twitter and Facebook) to encourage broader participation. The project's goal is to further scholarship and encourage public conversation on race and materiality. To this end the faculty have created a website, a Facebook page, Twitter account, and are working on an open-access curriculum to support dialogue in schools and informal learning settings about the complex issues of art, race, and representation. The faculty are also collaborating on academic publications, including selected proceedings and an article on the symposium's "hybrid discourse" that combined university and community resources, expertise, and communication practices and brought together diverse voices in constructive conversation about the challenging issues surrounding E Pluribus Unum

Marshall University Music Department Presents the Marshall Winds Quintet

https://mds.marshall.edu/music_perf/1594/thumbnail.jp

The Transition Online: A Mixed-Methods Study of the Impact of COVID-19 on Students with Disabilities in Higher Education

Following the World Health Organization’s announcement of the global pandemic because of the Coronavirus Disease 2019, most Canadian universities transitioned to offering their courses exclusively online. One group affected by this transition was students with disabilities. Previous research has shown that the university experience for students with disabilities differs from those of their non-disabled peers. However, their unique needs are often not taken into consideration. As a result, students can become marginalized and alienated from the online classroom. In partnership with Student Accessibility Services, this research revealed the impact of the transition to online learning because of the pandemic for university students with disabilities. Students registered with Student Accessibility Services completed a survey about the effects of online learning during a pandemic on the students’ lives, education, and instructional and accommodation. It was clear from the results that online education during COVID-19 affected all aspects of the students’ lives, particularly to their mental health. This research provided a much-needed opportunity for students with disabilities to share the factors influencing their educational experience and identified recommendations instructors should consider when developing online courses to increase accessibility and improve engagement.Brock Library Open Access Publishing Fun

Renal disease pathophysiology and treatment:contributions from the rat

The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments in genome engineering now allow us to capitalize on the wealth of knowledge acquired over the last century. Here, we review rat models of hypertension, diabetic nephropathy, and acute and chronic kidney disease. These models have made important contributions to our understanding of renal diseases and have revealed key genes, such as Ace and P2rx7, involved in renal pathogenic processes. By targeting these genes of interest, researchers are gaining a better understanding of the etiology of renal pathologies, with the promised potential of slowing disease progression or even reversing the damage caused. Some, but not all, of these target genes have proved to be of clinical relevance. However, it is now possible to generate more sophisticated and appropriate disease models in the rat, which can recapitulate key aspects of human renal pathology. These advances will ultimately be used to identify new treatments and therapeutic targets of much greater clinical relevance

Restriction of HIV-1 Genotypes in Breast Milk Does Not Account for the Population Transmission Genetic Bottleneck That Occurs following Transmission

BACKGROUND. Breast milk transmission of HIV-1 remains a major route of pediatric infection. Defining the characteristics of viral variants to which breastfeeding infants are exposed is important for understanding the genetic bottleneck that occurs in the majority of mother-to-child transmissions. The blood-milk epithelial barrier markedly restricts the quantity of HIV-1 in breast milk, even in the absence of antiretroviral drugs. The basis of this restriction and the genetic relationship between breast milk and blood variants are not well established. METHODOLOGY/PRINCIPAL FINDINGS. We compared 356 HIV-1 subtype C gp160 envelope (env) gene sequences from the plasma and breast milk of 13 breastfeeding women. A trend towards lower viral population diversity and divergence in breast milk was observed, potentially indicative of clonal expansion within the breast. No differences in potential N-linked glycosylation site numbers or in gp160 variable loop amino acid lengths were identified. Genetic compartmentalization was evident in only one out of six subjects in whom contemporaneously obtained samples were studied. However, in samples that were collected 10 or more days apart, six of seven subjects were classified as having compartmentalized viral populations, highlighting the necessity of contemporaneous sampling for genetic compartmentalization studies. We found evidence of CXCR4 co-receptor using viruses in breast milk and blood in nine out of the thirteen subjects, but no evidence of preferential localization of these variants in either tissue. CONCLUSIONS/SIGNIFICANCE. Despite marked restriction of HIV-1 quantities in milk, our data indicate intermixing of virus between blood and breast milk. Thus, we found no evidence that a restriction in viral genotype diversity in breast milk accounts for the genetic bottleneck observed following transmission. In addition, our results highlight the rapidity of HIV-1 env evolution and the importance of sample timing in analyses of gene flow.National Institute of Child Health and Human Development; National Institutes of Health (R01 HD 39611, R01 HD 40777); International Maternal Pediatric Adolescent AIDS Clinical Trials Group (U01 AI068632-01); National Institutes of Health Cellular, Biochemical; Molecular Sciences Training Program Grant (T 32 067587

Recruitment Strategies for Caregivers of Children with Mental Health Problems

PURPOSE: The aim of this study was to describe strategies for recruiting participants into an intervention study that focused on improving problem-solving skills in caregivers of children with mental health problems. BACKGROUND: Caregivers of children with mental health problems report feeling physically and psychologically overwhelmed and have high rates of depression because of the demands of caregiving. Research on the needs of these caregivers and interventions to ameliorate their stress is needed. However, recruiting this population can be particularly difficult because of the stigma of mental illness. Available literature on recruitment of caregivers of persons with physical illness cannot be transferred to caregivers of children with mental health problems because of the different caregiving situations. There is a need to identify effective recruitment strategies to reduce cost and answer research questions. Clinical nurse specialists have the skills to facilitate the recruitment of research participants. We revised and expanded health system referrals, community outreach, and recruiting advertisement (ads). When these strategies did not increase recruitment, radio ads were used. The Andersen's Behavioral Model of Health Services Utilization was selected as a guiding framework. OUTCOME: Radio ads were the most effective strategy for recruiting caregivers of children with mental health problems for this study. CONCLUSION: Recruitment was ultimately successful because we were flexible and made decisions consistent with the Andersen's Behavioral Model of Health Services Utilization. IMPLICATIONS: Clinical nurse specialists who study this population of caregivers should really consider the use of radio ads and systematically track which recruitment strategies lead to the greatest number of participants screened, eligible, and enrolled into studies