Mosaic of Cancer

The Mosaic of Cancer is a collection of images submitted by over 40 medical specialists, researchers, cancer patients and loved ones to describe how they see cancer. In this way, cancer is presented as both scientific and human. Doctors and researchers provided images to explain what cancer looks like at microscopic levels, how it manifests as tumors and how cancer is treated. Patients and loved ones submitted images to exemplify how cancer impacts their lives and how they understand cancer through non-scientific images. The goal of The Mosaic is to create understanding and community within those who contributed and view it. The Mosaic is both a teaching tool and an illustration of cancer’s broad impact. No two submitted images are the same, revealing how uniquely each person experiences cancer. The Mosaic has been presented and displayed in multiple venues to evoke emotion and awareness about cancer

Importance of complete assessment in the work-up of late onset mania

A female, age 78, with generalized anxiety disorder (GAD), history of major depression, and hypothyroidism presents for mood and anxiety concerns. Her mood is depressed, and sleep, appetite, energy, and concentration are poor. She recently saw a geriatric psychiatrist and described no past manic episodes, psychotic symptoms, or family history for bipolar disorder. No one has concerns about her cognition. She began levothyroxine 150 mcg 3 weeks ago for newly diagnosed hypothyroidism. On exam, she is talkative, overinclusive, has almost pressured speech, labile mood, and lid lag. Neuropsychology testing, CBC, and CMP are normal. TSH is 0.173. She is diagnosed with GAD exacerbated by hyperthyroidism due to over-replaced thyroid hormone causing a hypomanic syndrome. Possibly she was hyperthyroid prior to burnout and recent hypothyroid state, explaining the temporality of her manic symptoms. She reports feeling better at follow-up after medication adjustment. Late-onset mania is a (hypo)manic syndrome in a person 50 or older without a previous history of mania3. 5-10% of patients are 50+ years when they experience their first manic episode of bipolar disorder2. However, (hypo)manic syndromes can also be due to vascular etiology, dementia, medications, renal failure, and thyroid derangement. One study reports a 2.8% prevalence of organic cause of mania in those \u3e65 compared to 1.2% prevalence in those Almeida, O. P., & Fenner, S. (2002). Bipolar disorder: similarities and differences between patients with illness onset before and after 65 years of age. International psychogeriatrics, 14(3), 311–322. Arnold, I., Dehning, J., Grunze, A., & Hausmann, A. (2021). Old Age Bipolar Disorder-Epidemiology, Aetiology and Treatment. Medicina, 57(6), 587. Sami, M., Khan, H., & Nilforooshan, R. (2015). Late onset mania as an organic syndrome: A review of case reports in the literature. Journal of affective disorders, 188, 226–231.https://digitalcommons.unmc.edu/emet_posters/1036/thumbnail.jp

Characterisation of a pucBA deletion mutant from Rhodopseudomonas palustris lacking all but the pucBAd genes

Rhodopseudomonas palustris is a species of purple photosynthetic bacteria that has a multigene family of puc genes that encode the alpha and beta apoproteins, which form the LH2 complexes. A genetic dissection strategy has been adopted in order to try and understand which spectroscopic form of LH2 these different genes produce. This paper presents a characterisation of one of the deletion mutants generated in this program, the pucBAd only mutant. This mutant produces an unusual spectroscopic form of LH2 that only has a single large NIR absorption band at 800 nm. Spectroscopic and pigment analyses on this complex suggest that it has basically a similar overall structure as that of the wild-type HL LH2 complex. The mutant has the unique phenotype where the mutant LH2 complex is only produced when cells are grown at LL. At HL the mutant only produces the LH1-RC core complex

Opportunities and perspectives for utilisation of co-products in the meat industry

peer-reviewedMeat co-products are the non-meat components arising from meat processing/fabrication and are generated in large quantities on a daily basis. Co-products are considered as low added-value products, and in general it is difficult for industries to divert efforts into increasing their value. While many of these products can be edible those not used for human consumption or pet food is usually processed to be used as animal feed, fertilizer or fuel. However, to a large extent meat co-products are an excellent source of high nutritive value protein, minerals and vitamins and hence may be better diverted to contribute to alleviate the increasing global demand for protein. In this review the current uses, legislation and potential techniques for meat co-products processing are reviewed with the aim of showing a route to improve meat industry sustainability, profitability and better usage of available resources

Optimization of protein recovery from bovine lung by pH shift process using response surface methodology

peer-reviewedBACKGROUND Response surface methodology (RSM) was used in a sequential manner to optimize solubilization and precipitation conditions in the recovery of protein from bovine lung using pH shift. RESULTS Separate D‐optimal designs were employed for protein solubilization and precipitation. Independent variables investigated for protein solubilization were time (10–120 min), temperature (4–20 °C), pH (8.0–11.0) and solvent/sample ratio (2.5–10). Variables for protein precipitation were time (0–60 min) and pH (4.25–6.00). Soluble protein yields ranged from 323 to 649 g kg−1 and the quadratic model for protein solubilization revealed a coefficient of determination R2 of 0.9958. Optimal conditions for maximum protein solubility were extraction time 140 min, temperature 19 °C, pH 10.8 and solvent/sample ratio 13.02. Protein precipitation yields varied from 407 to 667 g kg−1, giving a coefficient of determination R2 of 0.9335. Optimal conditions for maximum protein precipitation were pH 5.03 and 60 min. Based on the RSM model, solubilization conditions were manipulated to maximize protein solubilization under reduced water and alkaline usage. These conditions were also validated. CONCLUSION Models for solubilization and precipitation using bovine and porcine lung were validated; predicted and actual yields were in good agreement, showing cross‐species applicability of the results. © 2017 Society of Chemical Industr

Archeota, Fall/Winter 2022

Archeota is a platform for SJSU iSchool students to contribute to the archival conversation. It is written BY students, FOR students. It provides substantive content on archival concerns and issues and promotes professional development in the field of archival studies. Archeota upholds the core values of the archival profession. Contents: The Forward Club: Archival Outreach and Community Connections By Sarah Lewis Putting the Spotlight on Women’s History: The Significance of Reevaluating Historic Site Narratives By Lawrence Mullen Meet the 2022-2023 Archeota Team Farm to Folder: Found Ephemera Joins the Dziekanowski Farm Papers Collection By Emma Ruff An Archivists’ Evolving Role By Amanda Galvez My Journey to Becoming a Certified Archivist: A Five-Year Process By Heather Reinold Farewell to Our Fall 2022 Graduates Interviews With SAA Student Chapter Leaders The Katz Family Archive: A Reflection on Identity and Artifact Ownership By Kit Katz The Writer’s Guild Foundation: Interning in the Shalverson-Webb Library By Rachael Sevilla SJSU SAA Student Chapter 2022-2023 Board SJSU SAA Student Chapter Past Events 2022-2023https://scholarworks.sjsu.edu/saasc_archeota/1016/thumbnail.jp

Meet the Editorial Board

Editorial board for Volume 20 Issue 2 Summer 2022 of Oregon Undergraduate Research Journa

An Anti-American Ban On Critique: A Critical Policy Commentary

We are a group of educational leaders who are doctoral candidates and faculty members in the Educational Leadership for Social Justice EdD program at California State University, East Bay. Our work centers around 1) creating shared knowledge about inequities and how they are reproduced by institutional systems, such as education, and 2) finding ways to address these systemic issues to create a more equal, healthy society. This work is informed by multiple critical perspectives, such as critical pedagogy (Freire, 1970; hooks, 1994), critical race theory (Ladson-Billings & Tate, 1995), and Black feminisms (Collins, 2002; Crenshaw, 1989). These perspectives, while varying somewhat, offer a common thread guided by the understanding that the world operates via power relations that privilege some groups while subordinating others; but these relationships, and the oppressions that result, are masked by the dominant culture’s insistence on painting reality with a brush of neutrality and a failure to engage with our history in a way that helps us understand and act on its repercussions on humanity

A direct comparison of decision rules for early discharge of suspected acute coronary syndromes in the era of high sensitivity troponin

Background: We tested the hypothesis that a single high sensitivity troponin at limits of detection (LOD HSTnT) (&lt;5 ng/l) combined with a presentation non-ischaemic electrocardiogram is superior to low-risk Global Registry of Acute Coronary Events (GRACE) (&lt;75), Thrombolysis in Myocardial Infarction (TIMI) (≤1) and History, ECG, Age, Risk factors and Troponin (HEART) score (≤3) as an aid to early, safe discharge for suspected acute coronary syndrome. Methods: In a prospective cohort study, risk scores were computed in consecutive patients with suspected acute coronary syndrome presenting to the Emergency Room of a large English hospital. Adjudication of myocardial infarction, as per third universal definition, involved a two-physician, blinded, independent review of all biomarker positive chest pain re-presentations to any national hospital. The primary and secondary outcome was a composite of type 1 myocardial infarction, unplanned coronary revascularisation and all cause death (MACE) at six weeks and one year. Results: Of 3054 consecutive presentations with chest pain 1642 had suspected acute coronary syndrome (52% male, median age 59 years, 14% diabetic, 20% previous myocardial infarction). Median time from chest pain to presentation was 9.7 h. Re-presentations occurred in eight hospitals with 100% follow-up achieved. Two hundred and eleven (12.9%) and 279 (17%) were adjudicated to suffer MACE at six weeks and one year respectively. Only HEART ≤3 (negative predictive value MACE 99.4%, sensitivity 97.6%, %discharge 53.4) and LOD HSTnT strategy (negative predictive value MACE 99.8%, sensitivity 99.5%, %discharge 36.9) achieved pre-specified negative predictive value of &gt;99% for MACE at six weeks. For type 1 myocardial infarction alone the negative predictive values at six weeks and one year were identical, for both HEART ≤3 and LOD HSTnT at 99.8% and 99.5% respectively. Conclusion: HEART ≤3 or LOD HSTnT strategy rules out short and medium term myocardial infarction with ≥99.5% certainty, and short-term MACE with &gt;99% certainty, allowing for early discharge of 53.4% and 36.9% respectively of suspected acute coronary syndrome. Adoption of either strategy has the potential to greatly reduce Emergency Room pressures and minimise follow-up investigations. Very early presenters (&lt;3 h), due to limited numbers, are excluded from these conclusions. </jats:sec