Fluoride poisoning and the effect on collagen biosynthesis of osseus and non-osseus tissues of rabbit

Fluoride poisoning Is known to cause a debilitating condition clinically referred to as Fluorlsls. The present Investigation on the experimental animal model has been carried out to collect Information on the precise nature of fluoride action, with special reference to collagen biosynthesis. Rabbits subjected to Fluoride poisoning for varying time Intervals were administered with carbon labelled proline. Both osseus and non-osseus tissues were analyzed to measure the rate of Incorporation of labelled proline, and Index for collagen biosynthesis. Part I of the article is dealing with 14C proline uptake by Hydrolyzed collagen (obtained by centrifugation at 5000 × g) and residual protein of tissues viz: Bone, Tendon, Muscle, Kidney cortex, Skin, Lung, Pinna and Trachea. Part II of the article Is dealing with 14C proline uptake by different fraction of collagen Viz: collagenase digested fraction and separated by centrifugation at 9000 × g ; native collagen fibril, acid soluble collagen, alkali soluble collagen and non-collagenous protein. The results obtained In Part I, suggest that In Fluoride poisoning collagen biosynthesis has been greatly impaired both In osseus and non-ossues tissues. This has been further confirmed by the results obtained in Part II of the investigation

A non destructive method to detect the incipient fault in rolling element bearing

It is essential to have prior warning of incipient fault (s) in any critical equipment occurring due to vibration. Vibration monitoring is good nondestructive technique to detect the fault of machines at an early stage. Capturing vibration signature of machines at slow speed is a difficult task due to impact of low energy, mostly absorbed by the structural path and falls much below the cut off frequency of the normally available accelerometer. To resolve the issue, a systematic proce-dure has been developed. It has the facility to break the signal in different level, envelope capturing and finally convert to frequency spectrum. The system has been tested under various operating condition that suits to industry to diagnose the problem of bearing. The method can predict the problem very well at its inception

The synergistic efficacy of hydroxychloroquine with methotrexate is accompanied by increased erythrocyte mean corpuscular volume

Objectives To determine whether concomitant HCQ modulates the increase in erythrocyte mean corpuscular volume (MCV) caused by MTX therapy, and whether this is associated with improved clinical response in RA. Methods A retrospective observational analysis was conducted on two independent hospital datasets of biologic-naïve, early-RA patients who started oral MTX. Baseline characteristics, DAS28-ESR and monthly MCV after starting MTX were obtained. Conventional and machine-learning statistical approaches were applied to the discovery cohort (Cohort 1, 655 patients) and results validated using Cohort 2 (225 patients). Results HCQ therapy with MTX was associated with a 2-fold increase in the likelihood of response defined in this study as clinical remission or low disease activity at 6 months (P 5 fl class, which contained the most patients, compared with MTX alone. Conclusion Our data provide mechanistic insight into the synergistic clinical benefit of concomitant HCQ with MTX, boosting the rise in MCV, which could serve as a companion biomarker of treatment response

Behavior of Buildings in August 21, 1988 Bihar-Nepal Earthquake

A moderate size earthquake rocked Bihar-Nepal border at 4.40 hrs. on August 21, 1988 causing wide spread devastation leading to loss of many lives and economic loss to the people of that region. The paper describes the study of damages occurred in masonry buildings, reinforced concrete buildings and liquefaction of the soil. The weakness of construction causes of damage and lessons learnt from the performance of structures are highlighted. The traditional and old structures without any earthquake resistance measures has suffered greater damage. The new reconstruction and strengthening measures must take into consideration the experience of failure of structures

Hidden Sp(2s+1)- or SO(2s+1)-symmetry and new exactly solvable models in ultracold atomic systems

The high spin ultracold atom models with a special form of contact interactions, i.e., the scattering lengthes in the total spin-$2,4 \cdots$ channels are equal but may be different from that in the spin-0 channel, is studied. It is found that those models have either $Sp(2s+1)$-symmetry for the fermions or $SO(2s+1)$-symmetry for the bosons in the spin sector. Based on the symmetry analysis, a new class of exactly solvable models is proposed and solved via the Bethe ansatz. The ground states for repulsive fermions are also discussed.Comment: 6 pages, 2 figure

Size dependent magnetic properties and cation inversion in chemically synthesized MnFe2O4 nanoparticles

MnFe2O4nanoparticles with diameters ranging from about 4to50nm were synthesized using a modified coprecipitation method. X-ray diffractograms revealed a pure phase spinel ferrite structure for all samples. Transmission electron microscopy showed that the particles consist of a mixture of both spherical (smaller) and cubic (larger) particles dictated by the reaction kinetics. The Néel temperatures (TN) of MnFe2O4 for various particle sizes were determined by using high temperature magnetometry. The ∼4nm MnFe2O4 particles showed a TN of about 320°C whereas the ∼50nm particles had a TN of about 400°C. The high Néel temperature, compared with the bulk MnFe2O4 TN of 300°C, is due to a change in cation distribution between the tetrahedral and octahedral sites of the spinel lattice. Results of extended x-ray absorption fine structure measurements indicate a systematic change in the cation distribution dependent on processing conditions

In-orbit performance of the EPIC-MOS detectors on XMM-Newton

XMM-Newton was launched into space on a highly eccentric 48 hour orbit on December 10th 1999. XMM-Newton is now in its fifth year of operation and has been an outstanding success, observing the Cosmos with imaging, spectroscopy and timing capabilities in the X-ray and optical wavebands. The EPIC-MOS CCD X-ray detectors comprise two out of three of the focal plane instruments on XMM-Newton. In this paper we discuss key aspects of the current status and performance history of the charge transfer ineffiency (CTI), energy resolution and spectral redistribution function (rmf) of EPIC-MOS in its fifth year of operation.Comment: 8 pages, 10 figures, SPIE Glasgow 21-25 June 2004, Session 548

Design and analysis of fractional factorial experiments from the viewpoint of computational algebraic statistics

We give an expository review of applications of computational algebraic statistics to design and analysis of fractional factorial experiments based on our recent works. For the purpose of design, the techniques of Gr\"obner bases and indicator functions allow us to treat fractional factorial designs without distinction between regular designs and non-regular designs. For the purpose of analysis of data from fractional factorial designs, the techniques of Markov bases allow us to handle discrete observations. Thus the approach of computational algebraic statistics greatly enlarges the scope of fractional factorial designs.Comment: 16 page