Fourth workshop on Experiments and Detectors for a Relativistic Heavy Ion Collider

We present a description of an experiment which can be used to search for effects of strong electromagnetic fields on the production of e(sup +) e(sup -) pairs in the elastic scattering of two heavy ions at the Relativistic Heavy Ion Collider (RHIC). A very brief discussion of other possible studies of electromagnetic phenomena at RHIC is also presented

The pathophysiology of migraine: year 2005

Migraine is a complex patholophysiology in which both central and peripheral components of the trigeminal pain pathway probably play a significant role, both in the symptoms and signs of the attack and in the mechanisms of action of antimigraine compounds, such as triptans, which constitute the most important therapy for aborting migraine pain and posses several mechanisms on 5–HT receptor–mediated actions. The experimental neurogenic inflammation model represents a simple procedure to obtain preliminary information on well characterized receptortargeted drugs. The apparent paradox observed with certain drugs that are shown to be effective in this model but not in clinical trials offers the opportunity to better manipulate structure–activity to obtain the best pharmacological profile using an array of experimental models. The observation that nitric oxide donors induce migraine–like pain in migraineours and that nitric oxide plays a pivotal role in the control of several functions in the central nervous system, has prompted the use of such molecules for better understanding the pathophysiology of migraine attacks. A link between central and peripheral components of the trigeminal pain pathway is provided by the observation that cortical spreading depression in the rat activates trigeminovascular afferents and induces a series of cortical meningeal and brainstem events consistent with the development of headache. Studies in humans support the hypothesis that cortical spreading depression underlies migraine.aura. Therefore, tt is possible that visual, motor or sensory aura might be responsible for the generation of the pain through the above mechanism

Passive States for Essential Observers

The aim of this note is to present a unified approach to the results given in \cite{bb99} and \cite{bs04} which also covers examples of models not presented in these two papers (e.g. $d$-dimensional Minkowski space-time for $d\geq 3$). Assuming that a state is passive for an observer travelling along certain (essential) worldlines, we show that this state is invariant under the isometry group, is a KMS-state for the observer at a temperature uniquely determined by the structure constants of the Lie algebra involved and fulfills (a variant of) the Reeh-Schlieder property. Also the modular objects associated to such a state and the observable algebra of an observer are computed and a version of weak locality is examined.Comment: 27 page

Factors associated with post-arrest withdrawal of life-sustaining therapy.

INTRODUCTION: Most successfully resuscitated cardiac arrest patients do not survive to hospital discharge. Many have withdrawal of life sustaining therapy (WLST) as a result of the perception of poor neurologic prognosis. The characteristics of these patients and differences in their post-arrest care are largely unknown. METHODS: Utilizing the Penn Alliance for Therapeutic Hypothermia Registry, we identified a cohort of 1311 post-arrest patients from 26 hospitals from 2010 to 2014 who remained comatose after return of spontaneous circulation. We stratified patients by whether they had WLST post-arrest and analyzed demographic, arrest, and post-arrest variables. RESULTS: In our cohort, 565 (43%) patients had WLST. In multivariate regression, patients who had WLST were less likely to go to the cardiac catheterization lab (OR 0.40; 95% CI: 0.26-0.62) and had shorter hospital stays (OR 0.93; 95% CI: 0.91-0.95). When multivariate regression was limited to patient demographics and arrest characteristics, patients with WLST were older (OR 1.18; 95% CI: 1.07-1.31 by decade), had a longer arrest duration (OR 1.14; 95% CI: 1.05-1.25 per 10min), more likely to be female (OR: 1.41; 95% CI: 1.01-1.96), and less likely to have a witnessed arrest (OR 0.65; 95% CI: 0.42-0.98). CONCLUSION: Patients with WLST differ in terms of demographic, arrest, and post-arrest characteristics and treatments from those who did not have WLST. Failure to account for this variability could affect both clinical practice and the interpretation of research

How Do Californians Define Safe Sex?

Objectives: We examined definitions of “safe sex” among adults in California, and assessed whether definitions varied by sociodemographic characteristics and sexual behavior. Methods: We analyzed crosssectional data from the “AIDS Knowledge, Attitudes, Beliefs, and Behaviors (KABB) Survey,” a statewide telephone survey of California adults conducted in 2000. Results: The four most common definitions of safe sex were condom use (68.0%), abstinence (31.1%), monogamy (28.4%), and safe partner (18.7%). Definitions were associated with sex, age, race/ethnicity, education, and number of sexual partners in the past 12 months. Conclusions: Most adults defined safe sex in terms of condom use either alone or in conjunction with other methods. Individuals’ definitions were complex and varied across sociodemographic groups which suggest the need for policies and programs which reflect this diversity

Preconscious control of stereotype activation through chronic egalitarian goals

This research shows stereotype activation is controlled by chronic egalitarian goals. In the first 2 studies it was found that the stereotype of women is equally available to individuals with and without chronic goals, and the discriminant validity of the concept of egalitarian goals was established. In the next 2 experiments, differences in stereotype activation as a function of this individual difference were found. In Study 3, participants read attributes following stereotypical primes. Facilitated response times to stereotypical attributes were found for nonchronics but not for chronics. This lack of facilitation occurred at stimulus onset asynchronies (SOAs) where effortful correction processes could not operate, demonstrating preconscious control of stereotype activation due to chronic goals. In Study 4, inhibition of the stereotype was found at an SOA where effortful processes of stereotype suppression could not operate. The data reveal that goals are activated and used preconsciously to prevent stereotype activation, demonstrating both the controllability of stereotype activation and the implicit role of goals in cognitive control. The current research addresses an important question for understanding both the nature of stereotyping and the nature of cognitive control: Can one's commitment to a goal lead to control over th

Moving from evidence-based medicine to evidence-based health.

While evidence-based medicine (EBM) has advanced medical practice, the health care system has been inconsistent in translating EBM into improvements in health. Disparities in health and health care play out through patients' limited ability to incorporate the advances of EBM into their daily lives. Assisting patients to self-manage their chronic conditions and paying attention to unhealthy community factors could be added to EBM to create a broader paradigm of evidence-based health. A perspective of evidence-based health may encourage physicians to consider their role in upstream efforts to combat socially patterned chronic disease